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Modifier risk gene
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Genome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci is determined primarily by altered expression of the causal gene, due to variation in binding of transcription factors and chromatin-modifying proteins that directly regulate the transcriptional apparatus.
18p
vibransone
28-03-2024
4
1
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Gene expression profiling (GEP) via microarray analysis is a widely used tool for assessing risk and other patient diagnostics in clinical settings. However, non-biological factors such as systematic changes in sample preparation, differences in scanners, and other potential batch effects are often unavoidable in long-term studies and meta-analysis.
9p
vikentucky2711
26-11-2020
9
0
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Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the BRCA genes, BRCA1 or BRCA2, the risk of developing breast or ovarian cancer is significantly increased.
9p
vijisoo2711
29-09-2020
11
1
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MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma.
8p
vijisoo2711
29-09-2020
9
1
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Hamartomatous polyposis syndromes (HPS) are inherited conditions associated with high cancer risk. They include the Peutz-Jeghers and the PTEN hamartoma tumor syndromes, which are caused by mutations in the LKB1 and PTEN genes, respectively.
6p
vilisa271
22-09-2020
8
1
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Genetic factors may influence an individual’s sensitivity to ionising radiation and therefore modify his/her risk of developing papillary thyroid carcinoma (PTC).
9p
vidhaka2711
31-07-2020
32
1
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Previous studies have found that polymorphisms of the DNA repair gene X-ray repair crosscomplementing group 1(XRCC1) and environmental factors are both associated with an increased risk of stomach cancer, but no study has reported on the potential additive effect of these factors among Thai people.
7p
vimanama2711
30-07-2020
11
2
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Our society has a great concern about transgenic crops regarding mixing of genetic materials between species whose hybridization is not possible naturally. Different public policies on the development and use of genetically modified organisms (GMOs) are of high concern with defining proper risk management strategies. Researchers are in agreement that this technology „„tampers with nature‟‟ in an unacceptable manner.
10p
angicungduoc6
22-07-2020
10
2
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Is RNASEL:P.Glu265* a modifier of early-onset breast cancer risk for carriers of high-risk mutations
Breast cancer risk for BRCA1 and BRCA2 pathogenic mutation carriers is modified by risk factors that cluster in families, including genetic modifiers of risk. We considered genetic modifiers of risk for carriers of high-risk mutations in other breast cancer susceptibility genes.
7p
vibaku2711
22-07-2020
7
1
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Accumulating evidence indicates inherited risk in the aetiology of lung cancer, although smoking exposure is the major attributing factor. Family history is a simple substitute for inherited susceptibility.
17p
vikuala271
13-06-2020
7
1
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Vasovagal syncope (VVS) is common in children and significantly affects their quality of life. To our knowledge, this the first case report of SCN5A gene mutation associated with VVS and third-degree atrioventricular block (atrioventricular block, AVB), which could help pediatricians aware that VVS is not always a benign condition and help to identify VVS children at the risk of sudden death.
5p
viorochimaru2711
29-05-2020
9
1
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