Molecular findings

Myelodysplastic syndrome (MDS) is known to arise through the pathogenic bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells (HSC). However, due to the strong heterogeneity of MDS patients, it is difficult to find common targets in studies with limited sample sizes. This study aimed to describe sequential molecular changes and identify biomarkers in MSC of MDS transformation.

14p vikoch 27-06-2024 1 1   Download

This volume reviews the current state of research concerning bacterial virulence factors and the infection biology of Helicobacter pylori, which is the leading cause of peptic ulcers and gastric cancer worldwide. The chapters include cutting-edge findings on this fascinating microbe and discuss the general strategies of H. pylori infection and persistence, news on important H. pylori virulence factors, crosstalk with the microbiota, hot novel models and signaling mechanisms, risk factors of gastric disease and stomach cancer, and the impact of H. pylori infection on non-gastric diseases.

363p vimeyers 29-05-2024 2 2   Download

his study focused on finding alkaloid compounds collected from Chemfaces database that inhibit HER2 enzyme employing computational methods such as molecular docking and ADMET prediction. Out of 118 phytochemicals docked to the ATP binding site of the HER2 kinase domain, 10 alkaloid compounds exhibited higher binding affinity than the reference inhibitor and satisfied the Lipinski’s rule of five. All compounds have good pharmacokinetic properties.

10p dianmotminh02 03-05-2024 4 3   Download

Ebook "Human cell transformation: Role of stem cells and the microenvironment" highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields.

239p ladongphongthanh1008 22-04-2024 1 1   Download

Ebook "Notch signaling in embryology and cancer" is to comprehensively cover a highly readable overview on our present knowledge of the role of Notch signalling for embryology and cancer, with a focus on new findings in molecular biology. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in cellular and molecular pathology to new concepts for prophylaxis and treatment of cancer.

346p ladongphongthanh1008 22-04-2024 2 1   Download

Ebook "Introduction to computational molecular biology" brings together major results in the field, in coherent and readable format. Setubal and Meidanis present a representative sample of problems in molecular biology, focusing on the algorithms that have been proposed to solve them. Readers will find background material on molecular biology, definitions of key terms, descriptions of models, and a full sample of algorithmic results.

308p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "The role of degenerate states in chemistry (Advances in chemical physics, Volume 124)" provides a forum for critical, authoritative evaluations in every area of the discipline. In a format that encourages the expression of individual points of view, experts in the field present comprehensive analyses of subjects of interest. Volume 124 collects innovative papers on "Complex States of Simple Molecular Systems," "Electron Nuclear Dynamics," "Conical Intersections and the Spin-Orbit Interaction," and many more related topics.

812p coduathanh1122 27-03-2024 1 1   Download

Ebook "Stem cells and cancer" would be to impart up-to-date information about the role of stem cells in the development of normal and cancerous tissue, the mechanisms that differentiate normal from cancerous functions, and the use of these findings in developing mechanism-based therapies.

304p cotieubac1004 15-03-2024 2 0   Download

Ebook "Biopolymers: A molecular paleontology approach" provides an overview, research compendium and an introduction to the science of molecular paleontology, including literature overview for non-geochemists. Analytical methods employed are included as a part of each chapter that underpin this branch of paleontology and indeed geochemistry. The primary usefulness of this volume is for organic geochemists, molecular palaeontologists, and molecular archeologists.

196p duongthandue0501 28-02-2024 3 1   Download

Ebook "Morphometries: Applications in Biology and Paleontology" with the quantitative characterization and analysis of morphological data, students increasingly see morphometrics as a necessary complement to molecular studies in their quests to understand the origin and maintenance of biodiversity. Moreover, morphometrics has recently been shown to have direct utility in phylogenetic contexts, by both finding new, and sharpening the definition of old, character states.

269p manmanthanhla0201 27-02-2024 1 1   Download

Ebook "Intermediate filaments" focuses on desmin and other intermediate filaments in disease and health. This new volume will serve as a resource for graduate students and researchers in the field. In this book, research groups summarize their findings in the IF field in particular focusing on the possible functional roles of IF proteins in cells and their relevance in pathological situations. Paulin's and Pekny's groups summarize these aspects in desmin and GFAP, respectively.

158p tachieuhoa 28-01-2024 6 2   Download

Ebook "Pathogenic yeasts" reviews various aspects of pathogenic yeasts and what is known about their molecular and cellular biology and virulence, in addition to looking at clinical and laboratory findings. As each chapter is written by a leading expert in the field, this book summarizes in one volume much of the latest research on several pathogenic yeasts, including Candida, Cryptococcus, Malassezia and yeasts of emerging importance.

367p tachieuhoa 28-01-2024 2 2   Download

Ebook "Inflammation and cancer: Methods and protocols" expands on the previous edition with an update on the broad spectrum of research models, techniques, and protocols used in laboratories by basic and clinical researchers. The chapters in this book are divided into two parts. Part One discusses the latest findings on the development and characterization of representative research models for chronic immune-based diseases and inflammation-associated cancers.

312p lucchinguyen 28-12-2023 9 3   Download

In this research, Molecular Dynamics (MD) simulations were conducted to explore the temperature effect on the microstructure and phase transition of the Ag0.25Au0.75 alloy. The findings reveal that as the temperature rises, the material's phase transition switches from crystalline to liquid and vice versa.

9p visharma 20-10-2023 3 3   Download

Part 1 book "Emery’s elements of medical genetics" includes content: The history and impact of genetics in medicine, the cellular and molecular basis of inheritance, chromosomes and cell division, finding the cause of monogenic disorders by identifying disease genes, laboratory techniques for diagnosis of monogenic disorders, patterns of inheritance, population and mathematical genetics, risk calculation, developmental genetics.

223p oursky03 21-08-2023 4 2   Download

The sea is a unique ecosystem for finding secondary metabolites from marine microorganisms. Many compounds produced by marine microorganisms with antibacterial activity have been applied in life. Furthermore, microorganisms are renewable raw materials and media for drug production, thus crucial for sustainable development in our life.

10p vicaptainmarvel 21-04-2023 6 3   Download

Circadian rhythms regulate key biological processes and the dysregulation of the intrinsic clock mechanism affects sleep patterns and obesity onset. The CLOCK (circadian locomotor output cycles protein kaput) gene encodes a core transcription factor of the molecular circadian clock influencing diverse metabolic pathways, including glucose and lipid homeostasis.

10p vinarcissa 21-03-2023 1 1   Download

The thesis is structured as follows: In Chapter 1, the scientific literature is summarized within the scope of this study. Chapter 2 provides a comprehensive overview of the principles of the applied computational approaches in this study. Chapter 3 identifies the important residues of the LsIA/α7 nAChR complex that affect the interactions between the toxin and the membrane protein due to C-terminal carboxylation of LsIA. The effects of C-terminal modification of LsIA on interactions with α3β2 nAChR, involved in cardiovascular diseases, were also investigated in Chapter 4.

234p runthenight04 02-02-2023 6 2   Download

Achillea alimeana Semiz & Uysal sp. nov. of sect. Santolinoidea DC. (Asteraceae), was described, diagnosed and illustrated as a new species. It was collected from Akdağ Mountains in Denizli Province. In this paper, the diagnostic characters of A. alimeana and its similar species were discussed in the morphological, palynological and molecular findings. As regards the new species, some notes on the ecology, conservation status, and distribution were submitted. A diagnostic key was given for related taxa.

10p lyhuyenthu 31-01-2023 5 2   Download

Combining Lipinski’s rule and docking method were used as a virtual screening tool to find out top hits from the large data base CHEMSPIDER with more than 1,4 million compounds.

8p viporsche 28-10-2022 4 2   Download