Molecular variations

In this research, a prototypical polymer system reinforced by a Silica nanoscopic inclusion is considered. Molecular Dynamics (MD) simulations are performed and used to characterize the conformational properties of the polymer chains in the neighborhood of the inclusion. It is shown that these chains are characterized by a specific tangential orientation which, together with the density profile and variations in chain mobility, allows for the geometric definition of the interphase region.

10p dathienlang1012 03-05-2024 2 0   Download

Ebook "Introduction to computational biology: An evolutionary approach" Analysis of molecular sequence data is the main subject of this introduction to computational biology. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models.

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Despite the increasing recognition that microbial communities within the human body are linked to health, we have an incomplete understanding of the environmental and molecular interactions that shape the composition of these communities.

13p vibransone 28-03-2024 7 1   Download

Genomic structural variants (SVs) can affect many genes and regulatory elements. Therefore, the molecular mechanisms driving the phenotypes of patients carrying de novo SVs are frequently unknown.

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Exome sequencing is now mainstream in clinical practice. However, identification of pathogenic Mendelian variants remains time-consuming, in part, because the limited accuracy of current computational prediction methods requires manual classification by experts.

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Comprehensive molecular profiling has revealed somatic variations in cancer at genomic, epigenomic, transcriptomic, and proteomic levels. The accumulating data has shown clearly that molecular phenotypes of cancer are complex and influenced by a multitude of factors.

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Tissue-specific integrative omics has the potential to reveal new genic elements important for developmental disorders. Methods: Two pediatric patients with global developmental delay and intellectual disability phenotype underwent array-CGH genetic testing, both showing a partial deletion of the DLG2 gene. From independent human and murine omics datasets, we combined copy number variations, histone modifications, developmental tissue-specific regulation, and protein data to explore the molecular mechanism at play.

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In ebook "Absolute and chemical electronegativity and hardness" systematic formulations of absolute and chemical electronegativity and hardness are analysed among the local and non-local electronic density contributions in the frame of density functional theory. It is analytically proved that in all proposed cases can be founded the proper conditions within the absolute and chemical formulations to equalise.

101p coduathanh1122 27-03-2024 2 1   Download

Advances in clinical genetic testing, including the introduction of exome sequencing, have uncovered the molecular etiology for many rare and previously unsolved genetic disorders, yet more than half of individuals with a suspected genetic disorder remain unsolved after complete clinical evaluation.

18p vicwell 29-02-2024 1 1   Download

Spatiotemporal heterogeneity originating from genomic and transcriptional variation was found to contribute to subtype switching in isocitrate dehydrogenase-1 wild-type glioblastoma (GBM) prior to and upon recurrence. Fluorescence-guided neurosurgical resection utilizing 5-aminolevulinic acid (5ALA) enables intraoperative visualization of infiltrative tumors outside the magnetic resonance imaging contrast-enhanced regions.

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The immune system has a central role in preventing carcinogenesis. Alteration of systemic immune cell levels may increase cancer risk. However, the extent to which common genetic variation influences blood traits and cancer risk remains largely undetermined. Here, we identify pleiotropic variants and predict their underlying molecular and cellular alterations.

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Ebook "Genomics of plant genetic resources - Volume 1: Managing, sequencing and mining genetic resources" collects 48 highly interdisciplinary articles describing how genomics improves our capacity to characterize and harness natural and artificially induced variation in order to boost crop productivity and provide consumers with high-quality food. This book will be an invaluable reference for all those interested in managing, mining and harnessing the genetic richness of plant genetic resources.

711p manmanthanhla0201 26-02-2024 4 1   Download

Part 1 book "Elementary methods of molecular quantum mechanics" includes content: Basic principles of quantum mechanics, elementary matrix methods, the particle in the box, the hydrogen like system, the variation method, the electron spin, many electron wavefunctions - slater, hartree–fock and related methods.

364p muasambanhan08 23-02-2024 3 1   Download

Ebook "Current ornithology (Volume 17)" publishes authoritative, up-to-date, scholarly reviews of topics selected from the full range of current research in avian biology. Topics cover the spectrum from the molecular level of organization to population biology and community ecology.

201p tachieuhoa 28-01-2024 4 2   Download

Ebook "Plant developmental biology - Biotechnological perspectives (Volume 2)" focuses on development-related areas, including tissue culture (somatic embryogenesis, microspore embryogenesis, somaclonal variation), plant processes (photosynthesis, seed maturation and seed proteins, fatty acids, vitamins, alkaloids, flower pigments and scent), signalling (amino compound-containing lipids, auxins, cytokinins and light), and molecular genetics of developmental regulation (RNA silencing, DNA methylation, epigenetics, activation tagging, homologous recombination and synthetic promoter engineering).

432p tachieuhoa 28-01-2024 6 2   Download

Part 1 book "The genetics of the pig" includes content: Systematics and evolution of the pig, genetic aspects of pig domestication, molecular genetics of coat colour variation, genetics of morphological traits and inherited disorders, molecular genetics, immunogenetics, cytogenetics and chromosome maps, pig genomics, behaviour genetics of the domestic pig, biology and genetics of reproduction.

251p muasambanhan05 22-01-2024 6 2   Download

Part 2 book "Computational physics - Simulation of classical and quantum systems" includes content: Rotational motion, molecular mechanics, thermodynamic systems, random walk and brownian motion, electrostatics, advection, waves, diffusion, nonlinear systems, simple quantum systems, variational methods for quantum systems.

303p muasambanhan02 18-12-2023 5 4   Download

Part 1 book "Animal behavior - An evolutionary approach" includes content: Free ranging macaque mothers exaggerate tool using behavior when observed by offspring, altered behavior and digestive outcomes in adult male rats primed with minimal colon pain as neonates - social transmission of avoidance behavior under situational change in learned and unlearned rats,... and other contents.

160p oursky10 07-12-2023 6 3   Download

Part 1 book "Concise review of veterinary microbiology" includes content: Structure of bacterial cells; cultivation, preservation and inactivation of bacteria; bacterial genetics and genetic variation; molecular diagnostic methods; laboratory diagnosis of bacterial disease; molecular subtyping of bacteria; antibacterial agents; antimicrobial susceptibility testing; bacterial resistance to antimicrobial drugs,... and other contents.

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The association involving mismatch repair (MMR) genes, molecular subtype and specific immune cell group in tumor microenvironment has been focused by more recent studies. Its prognosis value in lung adenocarcinoma (LUAD) neoadjuvant chemotherapy remains elusive.

12p visharma 20-10-2023 3 2   Download