Molecules detected

Ebook "Designing receptors for the next generation of biosensors" shows how synthetic receptors can be designed with characteristics that make them attractive alternatives to biological molecules in the sensory and diagnostics fields, with contributions from leading experts in the area.

271p coduathanh1122 27-03-2024 4 1   Download

Epigenetic characterization of cell-free DNA (cfDNA) is an emerging approach for detecting and characterizing diseases such as cancer. We developed a strategy using nanopore-based single-molecule sequencing to measure cfDNA methylomes. This approach generated up to 200 million reads for a single cfDNA sample from cancer patients, an order of magnitude improvement over existing nanopore sequencing methods.

13p vicwell 29-02-2024 2 1   Download

Ebook "Sample preparation in biological mass spectrometry" is to provide the researcher with important sample preparation strategies in a wide variety of analyte molecules, specimens, methods, and biological applications requiring mass spectrometric analysis as a detection end-point. In this volume we have compiled the contributions from several laboratories which are employing mass spectrometry for biological analysis.

1081p manmanthanhla0201 26-02-2024 2 2   Download

Ebook "Fluorescence of supermolecules, polymers, and nanosystems" which is the fourth in the Springer Series on Fluorescence, collects articles written by speakers of the 9th International Conference on Methods and Applications of Fluorescence: Spectroscopy, Imaging and Probes (MAF 9), held in Lisbon, Portugal, in September 2005, along with a few invited articles. The meeting, with more than 300 participants from 33 countries, included 18 plenary and invited lectures.

468p manmanthanhla0201 27-02-2024 4 2   Download

Ebook "Aptamers selected by Cell-SELEX for theranostics" as the fundamental tool used to generate aptamer molecules for a wide range of applications in molecular medicine, bioanalysis and chemical biology. Easily integrated into the natural heterogeneous cell matrix, aptamers can be effectively used in theranostics, bioanalysis, environment detection and biomedical studies.

352p nhanphanguyet 28-01-2024 2 2   Download

Ebook "NMR in biological systems: From molecules to humans" caters to the needs of: (i) graduate students who mostly learn such techniques from senior post-docs in the laboratory; (ii) those who are not experts in NMR but wish to understand if a particular problem in animal, plant, medical and pharmaceutical sciences can be answered by NMR; and (iii) those who are experts in chemistry and biochemistry and wish to know how NMR can provide them information on structural or functional aspect of proteins, nucleic acids, cells and tissues, human and plant organs and other biological materials.

552p tachieuhoa 28-01-2024 8 2   Download

Ebook "RNA detection: Methods and protocols" introduces different concepts and methods of detecting RNA in biological material in a variety of model systems. The chapters in this book discuss methods that will answer numerous biological questions that arise in the study of RNAs. Some of the topics covered in this book are single mRNA molecule detection in embryos and neurons; detection of mRNA and associated molecules by ISH-IEM on frozen sections; optimizing molecular beacons for intracellular analysis of RNA;...

492p lucchinguyen 28-12-2023 6 2   Download

Pancreatic ductal adenocarcinoma (PDAC), constituting 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. Lack of early detection of PDAC contributes to its poor prognosis as patients are often diagnosed at an advanced stage of disease.

17p vileonardodavinci 23-12-2023 4 4   Download

In this paper we present the development of a multi-axis differential optical absorption spectroscopy instrument capable of sensitively detecting NO2. The instrument collects the sun light scattered by the air molecules and aerosols in the atmosphere and measures the spectrum using a portable spectrometer of high sensitivity.

8p vispiderman 15-06-2023 3 2   Download

Surface Enhanced Raman Scattering (SERS) is a technique that is increasingly being used to detect trace amounts of various types of molecules, especially organic and biological molecules. The SERS effect is available mainly due to the SERS substrate - a noble metal surface that is rough at the nano level or a set of noble metal nanoparticles in a certain arrangement.

12p vispiderman 15-06-2023 2 1   Download

The objective of this project was to develop \(Ti{O_2}\) based multifunctional substrates through silver decoration, while simultaneously enhancing the photocatalytic performance of \(Ti{O_2}\) in the substrate. Employing Ag nanoparticles introduced additional functionality to the system, namely surface-enhanced Raman scattering (SERS), thus enabling the detection of trace amounts of organic molecules prior to their degradation, all with the same substrate.

123p runthenight04 02-02-2023 5 1   Download

The interaction between small molecules and neutral soluble dietary fiber is one of the proposed mechanisms determining the bioavailability of these components in the small intestine. However, the weak nature of these interactions makes it difficult to find an analytical method sensitive enough to detect them.

11p viginny 30-12-2022 6 2   Download

Fatty acyl-Coenzyme A species (acyl-CoAs) are key biomarkers in studies focusing on cellular energy metabolism. Existing analytical approaches are unable to simultaneously detect the full range of short- , medium-, and long-chain acyl-CoAs, while chromatographic limitations encountered in the analysis of limited amounts of biological samples are an often overlooked problem.

12p viginny 23-12-2022 4 4   Download

Hypomethylation of long interspersed nuclear element 1 (LINE-1) is characteristic of various cancer types, including colorectal cancer (CRC). Malfunction of several factors or alteration of methyl-donor molecules’ (folic acid and S-adenosylmethionine) availability can contribute to DNA methylation changes.

11p visusanwojcicki 28-06-2022 10 2   Download

Single-cell RNA-seq (scRNA-seq) data exhibits significant cell-to-cell variation due to technical factors, including the number of molecules detected in each cell, which can confound biological heterogeneity with technical effects. To address this, we present a modeling framework for the normalization and variance stabilization of molecular count data from scRNA-seq experiments.

15p vielonmusk 30-01-2022 8 0   Download

We present a new method, OMSV, for accurately and comprehensively identifying structural variations (SVs) from optical maps. OMSV detects both homozygous and heterozygous SVs, SVs of various types and sizes, and SVs with or without creating or destroying restriction sites. We show that OMSV has high sensitivity and specificity, with clear performance gains over the latest method.

19p vialfrednobel 29-01-2022 11 0   Download

There is no effective way to detect structure variations (SVs) and extra-chromosomal circular DNAs (ecDNAs) at single-cell whole-genome level. Here, we develop a novel third-generation sequencing platform-based single-cell whole-genome sequencing (scWGS) method named SMOOTH-seq (single-molecule real-time sequencing of long fragments amplified through transposon insertion).

19p viarchimedes 26-01-2022 14 0   Download

Nanopore long-read sequencing technology greatly expands the capacity of long-range, single-molecule DNA-modification detection. A growing number of analytical tools have been developed to detect DNA methylation from nanopore sequencing reads.

33p viarchimedes 26-01-2022 11 0   Download

Models developed using Nanopore direct RNA sequencing data from in vitro synthetic RNA with all adenosine replaced by N6 -methyladenosine (m6 A) are likely distorted due to superimposed signals from saturated m6 A residues.

23p viarchimedes 26-01-2022 13 0   Download

Long-read sequencing of full-length cDNAs enables the detection of structures of aberrant splicing isoforms in cancer cells. These isoforms are occasionally translated, presented by HLA molecules, and recognized as neoantigens.

30p viarchimedes 26-01-2022 13 0   Download