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Monoallelic expression
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Genomic imprinting is an epigenetic phenomenon that allows monoallelic expression of a subset of genes dependent on parental origin and is canonically regulated by DNA methylation.
4p
vialfrednobel
29-01-2022
11
0
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Monoallelic expression of autosomal genes has been implicated in human psychiatric disorders. However, there is a paucity of allelic expression studies in human brain cells at the single cell and genome wide levels.
18p
vilarryellison
29-10-2021
5
1
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MaGIC: A machine learning tool set and web application for monoallelic gene inference from chromatin
A large fraction of human and mouse autosomal genes are subject to random monoallelic expression (MAE), an epigenetic mechanism characterized by allele-specific gene expression that varies between clonal cell lineages. MAE is highly cell-type specific and mapping it in a large number of cell and tissue types can provide insight into its biological function. Its detection, however, remains challenging.
5p
vicoachella2711
27-10-2020
8
0
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