Monophosphate

Adenosine 5’-triphosphate (ATP) là hợp chất cao năng quan trọng nhất, giữ vai trò cung cấp năng lƣợng trong mọi tế bào sống. Bởi vì trong phân tử ATP có hai liên kết phosphate cao năng, năng lƣợng tự do sẽ đƣợc giải phóng khi ATP bị thủy phân thành Adenosine 5’-diphosphate (ADP) và một phosphate vô cơ (Pi), hoặc Adenosine monophosphate (AMP) và pyrophosphate (PPi). Do đó, phần lớn các hoạt động sống nhƣ vận chuyển, hấp thu dinh dƣỡng, sinh tổng hợp các chất, phân chia tế bào … đều sử dụng ATP nhƣ nguồn năng lƣợng trực...

67p canhchuon_1 19-06-2013 88 11   Download

Nitrogen monoxide (NO) is a cytotoxic effector molecule produced by macrophages that results in Fe mobilization from tumour target cells which inhibits DNA synthesis and mitochondrial respiration. It is well known that NO has a high affinity for Fe, and we showed that NO-mediated Fe mobilization is markedly potentiated by glutathione (GSH) generated by the hexose monophosphate shunt [Watts, R.N. & Richardson, D.R. (2001) J. Biol. Chem. 276, 4724–4732]. We hypothesized that GSH completes the coordination shell of an NO–Fe complex that is released from the cell.

10p research12 01-06-2013 47 3   Download

The naturally synchronous plasmodia of myxomycetes synthesize poly(b-L-malic acid), which carries out cell-specific functions. In Physarum polycephalum, poly(b-L-malate) [the salt form of poly(b-L-malic acid)] is highly concentrated in the nuclei, repressing DNA synthetic activity of DNA polymerases by the formation of reversible complexes. To test whether this inhibitory activity is cell-cycle-dependent, purified DNA polymerase a of P.

6p research12 01-06-2013 62 3   Download

Corynebacterium ammoniagenesis an overproducer of xanthosine-5¢-monophosphate (XMP) by consuming either glcose (glc) or glutamic acid (glu). Its energymetabolismwas studiedin vivousing 31 P NMR spectroscopy coupled with a circulating fermentation system (CFS). CFS enabled us to validate directly the cellular dependency on carbon sources and changes in biomolecules produced according to altera-tions in the cellular energetic status.

5p fptmusic 16-04-2013 39 3   Download

We determined differentially expressed genes in HT29 human colon cancer cells, both after short treatment with methotrexate (MTX) and after the resistance to MTX had been established. Screening was performed using Atlas Human Cancer 1.2K cDNA arrays. The analysis was carried out using Atlasimage 2.01 andgenespring6.1 software.

15p awards 05-04-2013 31 1   Download

Cytosolic 5¢-nucleotidase/phosphotransferase specific for 6-hydroxypurine monophosphate derivatives (cN-II), belongs to a class of phosphohydrolases that act through the formation of an enzyme–phosphate intermediate. Sequence alignment with members of the P-type ATPases/L-2-halo-acid dehalogenase superfamily identified three highly con-served motifs in cN-II and other cytosolic nucleotidases. Mutagenesis studies at specific amino acids occurring in cN-II conservedmotifswereperformed.

11p awards 05-04-2013 39 3   Download

The homodimeric 2C-methyl-d-erythritol 4-phosphate cytidylyltransferase contributes to the nonmevalonate pathway of isoprenoid biosynthesis. The crystal structure of the catalytic domain of the recombinant enzyme derived from the plant Arabidopsis thalianahas been solved by molecular replace-ment and refined to 2.0 A˚ resolution.

9p inspiron33 26-03-2013 35 5   Download

Thymidine kinase (TK) is the key enzyme in salvaging thymidine to pro-duce thymidine monophosphate. Owing to its ability to phosphorylate nucleoside analogue prodrugs, TK has gained attention as a rate-limiting drug activator.

11p galaxyss3 21-03-2013 55 3   Download

The molecular mechanism of cGMP-dependent protein kinase activation by its allosteric regulator cyclic-3¢,5¢-guanosine monophosphate (cGMP) has been intensely studied. However, the structural as well as thermo-dynamic changes upon binding of cGMP to type I cGMP-dependent protein kinase are not fully understood.

13p galaxyss3 19-03-2013 36 4   Download

Mollicutes are wall-less bacteria and cause various diseases in humans, ani-mals and plants. They have the smallest genomes with low G + C content and lack many genes of DNA, RNA and protein precursor biosynthesis. Nucleoside diphosphate kinase (NDK), a house-keeping enzyme that plays a critical role in the synthesis of nucleic acids precursors, i.e.

8p galaxyss3 19-03-2013 37 4   Download

The crystal structure of uridine monophosphate kinase (UMP kinase, UMPK) from the opportunistic pathogenUreaplasma parvumwas deter-mined and showed similar three-dimensional fold as other bacterial and archaeal UMPKs that all belong to the amino acid kinase family.

12p media19 05-03-2013 35 3   Download

We report the effects of stabilizing osmolytes (low molecular mass organic compounds that raise the midpoint of thermal denaturation) on the stabil-ity and function of RNase-A under physiological conditions (pH 6.0 and 25C). Measurements of Gibbs free energy change at 25C(DGD) and kinetic parameters, Michaelis constant (Km) and catalytic constant (kcat )of the enzyme mediated hydrolysis of cytidine monophosphate

9p viettel02 20-02-2013 44 2   Download

Atrial natriuretic peptide (ANP), via its guanylyl cyclase A (GC-A) recep-tor and intracellular guanosine 3¢,5¢-cyclic monophosphate production, is critically involved in the regulation of blood pressure. In patients with chronic heart failure, the plasma levels of ANP are increased, but the car-diovascular actions are severely blunted, indicating a receptor or postrecep-tor defect.

14p mobifone23 21-01-2013 32 5   Download

Gut granules are cell type-specific lysosome-related organelles found within the intestinal cells of Caenorhabditis elegans. To investigate the regulation of lysosome-related organelle size, we screened forC. elegansmutants with substantially enlarged gut granules, identifying alleles of the vacuolar-type H + -ATPase and uridine-5¢-monophosphate synthase (UMPS)-1.

20p mobifone23 18-01-2013 40 3   Download

The Per-Arnt-Sim (PAS) domain serine⁄threonine kinase PASKIN, or PAS kinase, links energy flux and protein synthesis in yeast, regulates glycogen synthesis and protein translation in mammals, and might be involved in insulin regulation in the pancreas.

12p cosis54 05-01-2013 33 3   Download

GMP synthetase is a glutamine amidotransferase that incorporates ammo-nia derived from glutamine into the nucleotide xanthosine 5¢-monophos-phate (XMP) to form guanosine 5¢-monophosphate (GMP). Functional coordination of domains in glutamine amidotransferases leads to upregula

13p cosis54 09-12-2012 38 3   Download

Tuyển tập các báo cáo nghiên cứu khoa học ngành toán học được đăng trên tạp chí toán học quấc tế đề tài: A calmodulin inhibitor, W-7 influences the effect of cyclic adenosine 3', 5'-monophosphate signaling on ligninolytic enzyme gene expression in Phanerochaete chrysosporium

34p dauphong11 04-02-2012 44 5   Download

DƯỢC LỰC Acyclovir có tác dụng chống virus Herpes simplex type I và type II, virus varicella-zoster. Tác dụng này do men Thynidine Kinase của virus biến đổi Acyclovir trong tế bào thành dạng monophosphate, sau đó thành diphosphate và triphosphate có hoạt tính. Dạng triphosphate ức chế sự tổng hợp và nhân đôi của DNA bằng cách ức chế men DNA polymerase của Herpes virus cũng như bằng cách kết dính với DNA của virus. Virus Epstein-Barr và virus Cytomegalo cũng nhạy cảm với acyclovir nhưng ít hơn Herpes virus và Varicella-Zoster virus. Acyclovir không có tác dụng...

4p abcdef_53 23-11-2011 55 6   Download

viên nang 250 mg : hộp 300 viên - Bảng A. viên nén 500 mg : hộp 150 viên - Bảng A. THÀNH PHẦN cho 1 viên Mycophénolate mofétil 250 mg cho 1 viên Mycophénolate mofétil 500 mg DƯỢC LỰC Mycophénolate mofétil có tên hóa học là ester 2-morpholinoéthylique de l'acide mycophénolique (MPA). MPA là một chất ức chế chọn lọc men ionosine monophosphate déhydrogénase (IMPDH), do đó nó ức chế sự tổng hợp nhân nucléotide của guanosine mà không cần thâm nhập vào ADN. Do sự tổng hợp nhân purine rất cần thiết cho tạo thành...

14p abcdef_51 18-11-2011 126 5   Download

Tuyển tập các báo cáo nghiên cứu về bệnh học thý y được đăng trên tạp chí Acta Veterinaria Scandinavica cung cấp cho các bạn kiến thức về bệnh thú yđề tài: Screening for bovine leukocyte adhesion deficiency, deficiency of uridine monophosphate synthase, complex vertebral malformation, bovine citrullinaemia, and factor XI deficiency in Holstein cows reared in Turkey...

8p coxanh_1 22-10-2011 55 5   Download