Mouse brain
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KRAS is the undisputed champion of oncogenes, and despite its prominent role in oncogenesis as mutated gene, KRAS mutation appears infrequent in gliomas. Nevertheless, gliomas are considered KRAS-driven cancers due to its essential role in mouse malignant gliomagenesis. Glioblastoma is the most lethal primary brain tumor, often associated with disturbed RAS signaling.
11p vishanshan 27-06-2024 1 1 Download
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Ebook "Neural stem cells in development, adulthood and disease" is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others.
219p ladongphongthanh1008 22-04-2024 1 1 Download
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Genetic variants in the voltage-gated sodium channels SCN1A, SCN2A, SCN3A, and SCN8A are leading causes of epilepsy, developmental delay, and autism spectrum disorder. The mRNA splicing patterns of all four genes vary across development in the rodent brain, including mutually exclusive copies of the fifth protein-coding exon detected in the neonate (5N) and adult (5A).
14p vibransone 28-03-2024 2 1 Download
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Part 1 book "Chromatography - The most versatile method of chemical analysis" by Leonardo de Azevedo Calderon includes contents: Purification of phospholipases A2 from American snake venoms; use of chromatography in animal ecology; 2D-NanoLC-ESI-MS/MS for separation and identification of mouse brain membrane proteins; analytical methods for quantification of drug metabolites in biological samples; current trends in sample treatment techniques for environmental and food analysis,... and other contents.
239p muasambanhan09 16-03-2024 4 1 Download
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Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau pathology and the local inflammatory response within the brain influence the broader immune system.
22p vicwell 29-02-2024 2 1 Download
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Alzheimer’s disease (AD) is characterized by the intra- and extracellular accumulation of amyloid-β (Aβ) peptides. How Aβ aggregates perturb the proteome in brains of patients and AD transgenic mouse models, remains largely unclear.
32p vicwell 29-02-2024 3 1 Download
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Glioblastoma (GBM) is the most aggressive type of brain tumor with heterogeneity and strong invasive ability. Treatment of GBM has not improved significantly despite the progress of immunotherapy and classical therapy. Epidermal growth factor receptor variant III (EGFRvIII), one of GBM-associated mutants, is regarded as an ideal therapeutic target in EGFRvIII-expressed GBM patients because it is a tumor-specific receptor expressed only in tumors.
11p vialfrednobel 23-12-2023 3 3 Download
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The neural stem/precursor cells (NSCs) in the ventricular-subventricular zone (V-SVZ) contribute to adult neurogenesis and gliogenesis, however, the mechanisms regulating NSC phenotype and functions remain to be elucidated.
7p visoros 01-11-2023 6 1 Download
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Results of the histological assessment of the prefrontal cortex reveal normal histology for T0, marked with an intact nucleus, and prominent and organized cells. Tissue architecture for T- reveals the reduction of cells and necrosis. T+ and T1 groups both maintained intact and well-stained nuclei that are comparable with T0. Interestingly, cellular proliferation has been noted for the Z. talanai group, which indicates possible neuronal differentiation. Overall, Z. talanai extract has been observed to exert antinecrotic capacities in the mouse brain.
7p nhanchienthien 25-07-2023 3 2 Download
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BEX family genes are expressed in various tissues and play significant roles in neuronal development. A mouse model of Bex3 gene knock-out was generated in this study, using the CRISPR-Cas9 system. Transcriptomic analysis of the brain was performed to identify genes and pathways under Bex3 regulation. Essential biological functions under the control of Bex3 related to brain development were identified.
21p lyhuyenthu 31-01-2023 4 2 Download
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We developed a new multiplexed reversed phase liquid chromatography-high resolution tandem mass spectrometric (LC-MS/MS) method. The method is based on isobaric labeling with a tandem mass tag (TMT10-plex) and stable isotope-labeled internal standards, and was used to analyze amino acids in mouse brain microdialysis samples.
10p viginny 23-12-2022 5 3 Download
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Volatile anesthetics increase levels of the neurotransmitter nitric oxide (NO) and the secondary messenger molecule cyclic guanosine monophosphate (cGMP) in the brain. NO activates the enzyme guanylyl cyclase (GC) to produce cGMP. We hypothesized that the NO-GC-cGMP pathway contributes to anesthesia-induced unconsciousness.
10p viottohahn 30-03-2022 9 1 Download
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N6 -methyladenosine (m6 A) is an important epitranscriptomic mark with high abundance in the brain. Recently, it has been found to be involved in the regulation of memory formation and mammalian cortical neurogenesis.
18p vimichaelfaraday 25-03-2022 13 1 Download
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Recent work has identified and mapped a range of posttranscriptional modifications in mRNA, including methylation of the N6 and N1 positions in adenine, pseudouridylation, and methylation of carbon 5 in cytosine (m5C).
16p vialfrednobel 29-01-2022 7 0 Download
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Fragile X syndrome (FXS) is an intellectual disability attributable to loss of fragile X protein (FMRP). We previously demonstrated that FMRP binds mRNAs targeted for nonsense-mediated mRNA decay (NMD) and that FMRP loss results in hyperactivated NMD and inhibition of neuronal differentiation in human stem cells.
13p viarchimedes 26-01-2022 20 1 Download
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Mouse models have allowed for the direct interrogation of genetic effects on molecular, physiological, and behavioral brain phenotypes. However, it is unknown to what extent neurological or psychiatric traits may be human- or primate-specific and therefore which components can be faithfully recapitulated in mouse models.
33p viarchimedes 26-01-2022 7 0 Download
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Ion channels play a crucial role in the development of ischemic brain injury. Recent studies have reported that the blockade of various types of ion channels improves outcomes in experimental stroke models. Amiodarone, one of the most effective drugs for life-threatening arrhythmia, works as a multiple channel blocker and its characteristics cover all four Vaughan-Williams classes.
7p vampires36 30-12-2021 15 1 Download
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The connection between genetics and miRNA expression can be determined through expression quantitative loci (eQTL) analysis, which has been extensively used in a variety of tissues, and in both human and model organisms.
14p viansan2711 30-07-2021 11 1 Download
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TALE-class homeodomain transcription factors Meis and Pbx play important roles in formation of the embryonic brain, eye, heart, cartilage or hematopoiesis. Loss-of-function studies of Pbx1, 2 and 3 and Meis1 documented specific functions in embryogenesis, however, functional studies of Meis2 in mouse are still missing.
16p viwyoming2711 16-12-2020 11 1 Download
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Outside these junctions, p120ctn is actively involved in the regulation of small GTPases of the Rho family, in actomyosin dynamics and in transcription regulation. We and others reported that loss of p120ctn in mouse embryos results in an embryonic lethal phenotype, but the exact developmental role of p120ctn during brain formation has not been reported.
18p viwyoming2711 16-12-2020 10 1 Download