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Mouse cancer model
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Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting chimeric molecules (PROTACs) may provide new therapeutic avenues for treatment of podophyllotoxin derivatives-resistant SCLC with LM, warranting further exploration.
12p
vishanshan
27-06-2024
2
1
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Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in~80% of PDAC patients. The second is cachexia, which compromises treatment tolerance for patients and reduces their quality of life.
19p
vishanshan
27-06-2024
1
1
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CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is wellestablished, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in.
11p
vibransone
28-03-2024
4
2
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Body mass index (BMI) has been implicated as a primary factor influencing cancer development. However, understanding the relationship between these two complex traits has been confounded by both environmental and genetic heterogeneity.
17p
vioraclene
31-03-2024
3
1
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Primary liver cancer has significant intratumor genetic heterogeneity (IGH), which drives cancer evolution and prevents effective cancer treatment. CRISPR/Cas9-induced mouse liver cancer models can be used to elucidate how IGH is developed.
24p
vicwell
29-02-2024
6
2
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Ebook "Mammary gland development: Methods and protocols" provides key molecular biological protocols and experimental strategies currently employed to study the various stages of mammary gland development. Chapters are divided into four parts covering genetically modified mouse models that exhibit prenatal and pubertal mammary gland phenotypes, 2D and 3D-model culture systems, methodologies for mammary stem cell isolation, and translational applications that provide a bridge between experimental studies of mammary gland development and the study of human breast cancer.
357p
lucchinguyen
28-12-2023
7
3
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Part 2 book "Mouse as a model organism" includes content: Experimental tumour models in mice; exploration of mmp function in mouse models of angiogenesis; tumor stroma interactions - focus on fibroblasts; experimental procedures to assay invasion associated activities of primary cultured fibroblasts; systemic instigation - a mouse model to study breast cancer as a systemic disease.
77p
muasambanhan03
25-12-2023
5
1
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We aimed to elucidate the temporal and spatial characteristics of tumor evolution in an oral squamous cell carcinoma (OSCC) mouse model with higher burden of lymphatic metastasis through high-throughput sequencing.
13p
vileonardodavinci
23-12-2023
5
3
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Glioblastoma (GBM) is the most aggressive type of brain tumor with heterogeneity and strong invasive ability. Treatment of GBM has not improved significantly despite the progress of immunotherapy and classical therapy. Epidermal growth factor receptor variant III (EGFRvIII), one of GBM-associated mutants, is regarded as an ideal therapeutic target in EGFRvIII-expressed GBM patients because it is a tumor-specific receptor expressed only in tumors.
11p
vialfrednobel
23-12-2023
3
3
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Malignant mesothelioma (MM) is an aggressive mesothelial cell cancer type linked mainly to asbestos inhalation. MM characterizes by rapid progression and resistance to standard therapeutic modalities such as surgery, chemotherapy, and radiotherapy. Our previous studies have suggested that tumor cell-derived connective tissue growth factor (CTGF) regulates the proliferation of MM cells as well as the tumor growth in mouse xenograft models.
12p
vialfrednobel
23-12-2023
8
4
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Oral squamous cell carcinoma (OSCC) is a common malignant tumor associated with poor prognosis. MicroRNAs (miRNAs) play crucial regulatory roles in the cancer development. However, the role of miRNAs in OSCC development and progression is not well understood. Methods We sought to establish a dynamic Chinese hamster OSCC animal model, construct miRNA differential expression profiles of its occurrence and development, predict its targets, and perform functional analysis and validation in vitro.
19p
vischultz
20-10-2023
6
2
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Breast tumors show heterogeneity containing cancer stem cells as a small subpopulation of a tumor mass. In the present research, our objective was to evaluate the immunogenicity of prepared nanoparticles containing a novel recombinant CD44v (rCD44v) protein in the mouse model.
14p
vischultz
20-10-2023
2
1
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Currently there are no established fertility preservation options for pre-pubertal boys facing cancer treatment. Granulocyte-colony stimulating factor (G-CSF) treatment has been proposed to be chemoprotective against spermatogonial cell loss in an alkylating chemotherapy model of busulfan-treated adult mice.
13p
vischultz
20-10-2023
4
1
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Part 1 book "Patient derived tumor xenograft models - Promise, potential and practice" includes content: PDX models - History and development, history of mouse cancer models, challenges and limitations of mouse xenograft models of cancer, tumor heterogeneity, immunodeficient mice - the backbone of patient derived tumor xenograft models,... and other contents.
230p
oursky06
17-10-2023
2
1
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It is widely accepted that chronic inflammatory bowel diseases significantly higher a risk for colorectal cancer development. Among different types of treatments for patients with colon cancer, novel protein-based thera‑ peutic strategies are considered. AIM To explore the effect of human plasma alpha-1 antitrypsin (AAT) protein in the chemically induced mouse model of colorectal cancer.
14p
vioracle
29-09-2023
5
2
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Part 1 book "The molecular basis of cancer" includes content: Oncogenes and signal transduction, tumor suppressor genes, DNA repair pathways and human cancer, epigenetics and cancer, infectious agents and cancer, environmental carcinogenesis, genetic mouse models of cancer.
483p
oursky01
24-07-2023
2
2
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Despite the emergence of stereotactic body radiotherapy (SBRT) for treatment of medically inoperable early-stage non-small-cell lung cancer patients, the molecular effects of focal exposure of limited lung volumes to highdose radiation have not been fully characterized. This study was designed to identify molecular changes induced by focal high-dose irradiation using a mouse model of SBRT.
21p
vinarcissa
21-03-2023
2
1
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Epidermal growth factor receptor (Egfr) has been the target of several drugs for cancers. The potential gender differences in genes in the Egfr axis have been suggested in humans and in animal models. Female and male mice from the same recombinant inbred (RI) strain have the same genomic components except the sex difference.
13p
vinarcissa
21-03-2023
5
1
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The purpose of this study was to investigate the role of RGS1 in gastric cancer in vitro and in vivo. Proliferation, migration, invasion, and colony formation of NCIN87 cells and drug-resistant NCIN87 cells (NCIN87-DR) were determined. Cell apoptosis and cell cycle were examined using a flow cytometry assay. RGS1 gene knock-down vector (pLVshshRGS1) and Xenograft tumor mouse model was generated.
11p
lyhuyenthu
31-01-2023
4
2
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Preclinical radiotherapy studies using mouse models are an indispensable step on the path from in vitro experiments to clinical implementation. In support of this step, dedicated small animal irradiators have been developed to provide a platform for testing new radiation strategies for cancer treatment.
8p
vironald
15-12-2022
12
3
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