Mouse cells

Leptomeningeal metastasis (LM) of small cell lung cancer (SCLC) is a highly detrimental occurrence associated with severe neurological disorders, lacking effective treatment currently. Proteolysis-targeting chimeric molecules (PROTACs) may provide new therapeutic avenues for treatment of podophyllotoxin derivatives-resistant SCLC with LM, warranting further exploration.

12p vishanshan 27-06-2024 2 1   Download

Ebook "p53 Protocols (Second edition)" expert researchers in the field detail many of the methods that address the challenging questions of the p53 field. These methods include the identification of the target genes and binding partners of gain of function p53 mutants, methods to determine stress response, autophagy or senescence induced by p53, cell cycle analysis, analysis of different phases of DNA replication modified by p53, and generation of pluripotent stem cells.

251p dongmelo 27-05-2024 3 2   Download

Ebook "Dendritic cell protocols" provides chapter and verse for many useful practical approaches to the art of studying dendritic cells. The book gives information on the usual techniques for derivation of human dendritic cells from precursor stem cells, such as monocytes. In addition it provides data on the difficult tasks of isolating dendritic cells directly from different tissues; whether dendritic cells from precursor cells or from tissues of mouse or human are required, this book contributes practical information.

489p dongmelo 27-05-2024 10 2   Download

Ebook "Advances in stem cell research" discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research.

401p ladongphongthanh1008 22-04-2024 4 2   Download

Ebook "Neural stem cells in development, adulthood and disease" is the first to specifically target developing, adult and diseased neural stem cells. It explores recent advances in the understanding of neural stem cell biology along with strategies that use these cells to tackle neurological diseases and brain aging. Ten inclusive chapters discuss a wide range of topics including neurogenesis, neurodegeneration, demyelinating disease, mood regulation, and spinal cord regeneration, among others.

219p ladongphongthanh1008 22-04-2024 1 1   Download

CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is wellestablished, generating gain-of-function alleles in somatic cancer models is still challenging because of the low efficiency of gene knock-in.

11p vibransone 28-03-2024 4 2   Download

Quantifying tissue-infiltrating immune and stromal cells provides clinically relevant information for various diseases. While numerous methods can quantify immune or stromal cells in human tissue samples from transcriptomic data, few are available for mouse studies.

15p vibransone 28-03-2024 5 2   Download

IL-4-driven alternative macrophage activation and proliferation are characteristic features of both antihelminthic immune responses and wound healing in contrast to classical macrophage activation, which primarily occurs during inflammatory responses.

22p vioraclene 31-03-2024 4 2   Download

The genetic origins of chemotherapy resistance are well established; however, the role of epigenetics in drug resistance is less well understood. To investigate mechanisms of drug resistance, we performed systematic genetic, epigenetic, and transcriptomic analyses of an alkylating agent-sensitive murine lymphoma cell line and a series of resistant lines derived by drug dose escalation.

11p vioraclene 31-03-2024 2 1   Download

Mutations in the DMD gene encoding dystrophin—a critical structural element in muscle cells— cause Duchenne muscular dystrophy (DMD), which is the most common fatal genetic disease. Clustered regularly interspaced short palindromic repeat (CRISPR)-mediated gene editing is a promising strategy for permanently curing DMD.

19p vibransone 28-03-2024 5 2   Download

The present study was undertaken to evaluate the effects of Thuocnamtieuu in AOM/ DSS-induced-colorectal tumors mice. 48 six-week-old Swiss mice were randomly divided into 06 groups. Two doses of Thuocnamtieuu were administered via intragastric gavage to Swiss mouse with AOM/ DSS induced colorectal tumours. After 28 days treatment, all mice were sacrified. Assessment of the number and size of colorectal tumours, histopathological analysis were performed.

9p virichard 28-03-2024 4 1   Download

Ebook "Stem cells: From Hydra to man" illustrates that there is more than human and mouse stem cells to learn from. Reflecting an enormous growth in the knowledge of stem cells in various organisms, the book presents the conceptual language and the nature of questions, as well as a summary of the advances in our understanding of stem cells from a comparative point of view that has resulted from the development of new technology and the development of novel model organisms over the past few decades.

198p cotieubac1004 15-03-2024 4 0   Download

Emerging evidence from mouse models is beginning to elucidate the brain’s immune response to tau pathology, but little is known about the nature of this response in humans. In addition, it remains unclear to what extent tau pathology and the local inflammatory response within the brain influence the broader immune system.

22p vicwell 29-02-2024 2 1   Download

Ebook "Muscle stem cells: Methods and protocols" provides leading-edge protocols in the study of the molecular and cellular biology of muscle stem cells. Chapters detail current and updated methods for muscle stem cell isolation, culture, molecular analysis, cellular analysis, and reintroduction in vivo as well as protocols for studying myogenic stem cells in non-mammalian model systems.

359p manmanthanhla0201 26-02-2024 2 1   Download

Part 2 book "Cryptosporidium - Methods and protocols" includes content: Use of mirnas to study host cell–parasite interactions; genetic manipulation of cryptosporidium parvum with crispr cas9; mouse models for use in cryptosporidium infection studies and quantification of parasite burden using flow cytometry, QPCR, and histopathology; calf clinical model of cryptosporidiosis for efficacy evaluation of therapeutics,... and other contents.

201p muasambanhan05 16-01-2024 1 0   Download

Part 1 book "Mouse cell culture - Methods and protocols" includes content: The culture of mouse embryonic stem cells and formation of embryoid bodies; derivation of primary mouse embryonic fibroblast (PMEF) cultures; embryonic skeletal muscle microexplant culture and isolation of skeletal muscle stem cells; ... and other contents.

119p muasambanhan04 07-01-2024 9 1   Download

Part 2 book "Mouse cell culture - Methods and protocols" includes content: Short and long term cultivation of embryonic and neonatal murine keratinocytes; isolation, culture and analysis of mouse mammary epithelial cells; isolation and culture of adult mouse hepatocytes; isolation and culture of mouse intestinal cells; the preparation of primary cortical neuron cultures and a practical application using immunofluorescent cytochemistry; ... and other contents.

143p muasambanhan04 07-01-2024 1 1   Download

Ebook "Mammary gland development: Methods and protocols" provides key molecular biological protocols and experimental strategies currently employed to study the various stages of mammary gland development. Chapters are divided into four parts covering genetically modified mouse models that exhibit prenatal and pubertal mammary gland phenotypes, 2D and 3D-model culture systems, methodologies for mammary stem cell isolation, and translational applications that provide a bridge between experimental studies of mammary gland development and the study of human breast cancer.

357p lucchinguyen 28-12-2023 7 3   Download

We aimed to elucidate the temporal and spatial characteristics of tumor evolution in an oral squamous cell carcinoma (OSCC) mouse model with higher burden of lymphatic metastasis through high-throughput sequencing.

13p vileonardodavinci 23-12-2023 5 3   Download

Melanoma is a malignant tumor characterized by high proliferation and aggressive metastasis. To address the molecular mechanisms of the proto-oncogene, Rous sarcoma oncogene (Src), which is highly activated and promotes cell proliferation, migration, adhesion, and metastasis in melanoma.

13p vialfrednobel 23-12-2023 6 3   Download