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Mucin 1
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T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a cell surface molecule that was first discovered on T cells. However, recent studies revealed that it is also highly expressed in acute myeloid leukemia (AML) cells and it is related to AML progression. As, Glutamine appears to play a prominent role in malignant tumor progression, especially in their myeloid group, therefore, in this study we aimed to evaluate the relation between TIM-3/Galectin-9 axis and glutamine metabolism in two types of AML cell lines, HL-60 and THP-1.
15p
vikoch
27-06-2024
4
1
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Intussusception is a rare condition in adults, accounting for 5% of intestinal intussusception and being responsible for approximately 1% of all adult bowel obstructions. Neoplastic origin is the most common etiology of intestinal intussusception in adults, unlike pediatric intussusception, which is usually idiopathic.
5p
vitiki
30-01-2024
3
2
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Part 1 book "Regulation of implantation and establishment of pregnancy in mammals" includes content: Introduction, history of maternal recognition of pregnancy, the role of steroid hormone receptors in the establishment of pregnancy in rodents, transmembrane mucin expression and function in embryo implantation and placentation, reflections on rodent implantation, the role of progesterone in maternal recognition of pregnancy in domestic ruminants, implantation and establishment of pregnancy in ruminants.
140p
muasambanhan01
11-12-2023
8
3
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According to the histopathological classification of lung tumors of the World Health Organization (WHO) 2015, update 2021, the adenocarcinoma group includes the following subtypes: (1) minimally invasive adenocarcinoma (MIA); (2) Invasive non-mucinous carcinoma (INMA); (3) Invasive mucinous carcinoma (IMA); (4) Colloidal adenocarcinoma (CA); (5) Fetal cancer (FA); (6) Enteric-type adenocarcinoma (EA).
8p
visoros
01-11-2023
1
1
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Programmed death-1 (PD-1) and T cell immunoglobulin and mucin-domain-containing molecule 3(Tim3) may be used as the biomarkers for the therapy in patients with peritoneal neoplasms. In the current study, the differential percentages of peripheral PD-1 and Tim-3 are explored to investigate whether to associate with primary sites and pathological types of patients with peritoneal neoplasms or not.
11p
vischultz
20-10-2023
6
1
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Signet ring cell carcinoma (SRCC) represents an extremely rare histological type for colon cancer, accounting for less than 1% of all colon neoplasms. SRCC is usually aggressive and it is associated with poor prognosis. It can be divided into mucinous adenocarcinoma (MAC) with signet cells and signet cell of more than 50% of the tumor area. Main differential diagnosis is metastatic gastric signet cell carcinoma.
5p
viintuit
26-09-2023
1
0
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T-cell immunoglobulin mucin-1 (TIM-1) has been reported to be associated with the biological behavior of several malignant tumors; however, it is not clear whether it has a role in cervical cancer (CC).
17p
vikolindagrabar
27-07-2022
2
2
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This study aims to investigate the clinical significance and prognostic value of mucinous component (MC) in colorectal adenocarcinoma (AC). Methods: Patients with colorectal AC and AC with MC (ACMC) (1–100%) underwent surgical resection between January 2007 and February 2018 were retrospectively reviewed.
12p
vielonmusk
21-01-2022
17
1
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Congenital pulmonary airway malformation (CPAM) is the most frequent congenital lung disorder. CPAM type 1 is the most common subtype, typically having a cystic radiological and histological appearance. Mucinous clusters in CPAM type 1 have been identified as premalignant precursors for mucinous adenocarcinoma. These mucinous adenocarcinomas and the mucinous clusters in CPAM commonly harbor a specific KRAS mutation.
4p
vimaine2711
26-03-2021
9
2
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Back pain and disc degeneration have a growing socioeconomic healthcare impact. Mucin 1 (MUC1) is a transmembrane glycoprotein whose extracellular and intracellular domains participate in cellular signaling. Little is currently known about the presence or role of MUC1 in human disc degeneration.
7p
vitennessee2711
02-02-2021
7
1
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Prostate androgen-regulated mucin-like protein 1 (PARM1) is a pro-proliferative and anti-apoptotic glycoprotein involved in the endoplasmic reticulum (ER) stress response. A single nucleotide polymorphism in the coding region of PARM1 has been associated with competence of bovine embryos to develop to the blastocyst stage.
12p
viwyoming2711
16-12-2020
13
1
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Mucin-1 is known to be over-expressed by various human carcinomas and is shed into the circulation where it can be detected in patient’s serum by specific anti-Mucin-1 antibodies, such as the tumour marker assays CA 15–3 and CA 27.29. The prognostic value of Mucin-1 expression in ovarian carcinoma remains uncertain.
9p
vijisoo2711
30-09-2020
4
0
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Approximately 1 in 5 women diagnosed with breast cancer are considered to have in situ disease, most often termed ductal carcinoma in situ (DCIS). Though recognized as a risk factor for the development of more invasive cancer, it remains unclear what factors contribute to DCIS development
17p
viamsterdam
18-09-2020
10
0
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Mucin 1 (MUC1) contributes to the growth and metastasis of various cancers, including lung cancer, and MUC1 gene length polymorphisms are associated with susceptibility to lung cancer and its prognosis. In contrast, the association between rs4072037, a single nucleotide polymorphism in MUC1, and lung cancer has not been well studied.
8p
vimale2711
21-08-2020
10
1
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More favorable treatment against epithelial ovarian cancer (EOC) is urgently needed because of its insidious nature at an early stage and a low rate of five-year survival. The current primary treatment, extensive surgery combined with chemotherapy, exhibits limited benefits for improving prognosis.
13p
vidhaka2711
31-07-2020
13
1
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Pancreatic ductal adenocarcinoma (PDA) remains the most aggressive cancers with a 5-year survival below 10%. Systemic delivery of chemotherapy drugs has severe side effects in patients with PDA and does not significantly improve overall survival rate.
13p
vibaku2711
22-07-2020
10
1
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The Tn neoantigen (GalNAcα1-O-Ser/Thr) is an O-glycan expressed in various types of human cancers. Studies in several Tn-expressing cancer cell lines and pancreatic tumors have identified loss of Cosmc expression caused by either mutations or promoter hypermethylation. In this study, we explored the mechanism(s) for Tn expression in human colorectal cancers (CRC).
15p
vimanila2711
29-06-2020
10
0
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The present study was carried out to evaluate the effect of oxytetracycline (OTC)- dosing at five different concentrations, viz., 0 mg (0X), 80 mg (1X), 240 mg (3X), 400 mg (5X) and 800 mg (10X) kg-1 biomass day-1 for 30 consecutive days on the growth, safety and intestinal histology of Nile tilapia, Oreochromis niloticus (L.) juveniles. The OTC-residues in the edible muscle were detected at scheduled intervals by LCMS/MS. A dose-dependent decline in feed intake, biomass and survival were recorded in OTC-dosed fish. The OTC-residue levels were 0, 204.75±45.75, 318.00±0.00, 778.50±145.
17p
nguathienthan3
27-02-2020
16
0
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The goal of this study was to identify the optimal marker or marker combinations for detection of gastrointestinal malignancies using reverse-transcriptase polymerase chain (RT-PCR) reaction. To detect the presence of tumors, we analyzed mucin 1 (MUC1), cytokeratin 19 (CK19), cytokeratin 20 (CK20), and human telomerase reverse transcriptase (hTERT) mRNA in the peripheral blood of 31 patients with gastrointestinal cancer and 30 healthy individuals.
10p
vikimsa
22-02-2019
21
0
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Mucin glycoproteins on breast cancer cells carry shortened carbohydrate chains. These partially deglycosylatedmucin 1 (MUC-1) structures are recognized by the monoclonal antibody SM3, which is being tested for its diagnostic utility. We used NMR spectroscopy to analyze the binding mode and thebindingepitopeof peptideandglycopeptideantigens to the SM3 antibody. The pentapeptide PDTRP and the glycopentapeptide PDT(O-a-D-GalNAc)RP are known lig-ands of the monoclonal antibody.
12p
research12
29-04-2013
38
2
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CHỦ ĐỀ BẠN MUỐN TÌM
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