Multi-drug resistant Enterobacteriaceae
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Carbapenem-resistant Enterobacteriaceae are considered by WHO as “critical” priority pathogens for which novel antibiotics are urgently needed. The dissemination of carbapenemase-producing Escherichia coli (CP-Ec) in the community is a major public health concern. However, the global molecular epidemiology of CP-Ec isolates remains largely unknown as well as factors contributing to the acquisition of carbapenemase genes.
18p vibransone 28-03-2024 4 2 Download
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Resistance to third-generation cephalosporins, often mediated by extended-spectrum beta-lactamases (ESBLs), is a considerable issue in hospital-associated infections as few drugs remain for treatment. ESBL genes are often located on large plasmids that transfer horizontally between strains and species of Enterobacteriaceae and frequently confer resistance to additional drug classes.
13p viellison 28-03-2024 5 2 Download
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Molecular methods that enable the detection of antimicrobial resistance determinants are critical surveillance tools that are necessary to aid in curbing the spread of antibiotic resistance. The objectives of the study were to determine the prevalence of multidrug-resistant Enterobacteriaceae species isolated from the urine samples in a tertiary care hospital and to detect their drug resistance patterns and their genetic characterization.
7p kethamoi5 03-06-2020 9 0 Download
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Klebsiella species belonging to the family Enterobacteriaceae, are known to cause a variety of human infections such as pneumonia, urinary tract infections, septicaemia, soft tissue infections and are an important cause of healthcare associated infections. The emergence of multidrug resistant Klebsiella is a growing problem worldwide. Klebsiella spp. are one of the most common organisms to carry plasmids encoding ESBL enzyme. They are associated with higher rates of treatment failure and death.
6p chauchaungayxua5 05-05-2020 19 2 Download
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Resistance to extended-spectrum cephalosporins among Enterobacteriaceae has been reported yet they serve as the last line treatment for severe infections in Uganda and other countries. This resistance often leads to nosocomial infection outbreaks and therapeutic failures from multidrug resistant bacteria.
6p vienzym2711 03-04-2020 13 1 Download
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A review of -multidrug-resistant Enterobacteriaceae in a neonatal unit in Johannesburg, South Africa
Multi-drug resistant organisms are an increasingly important cause of neonatal sepsis. Aim: This study aimed to review neonatal sepsis caused by multi-drug resistant Enterobacteriaceae (MDRE) in neonates in Johannesburg, South Africa.
9p virome2711 13-01-2020 11 1 Download
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K. pneumoniae is responsible for a wide variety of hospital and community-acquired infections, affecting patients with normal immune systems as well as those with pre-existing conditions. The Carbapenems are β-lactam antibiotics that are used in the treatment of infections caused by Extended Spectrum beta-Lactamases (ESBL) producing gram negative bacteria (GNB). Carbapenem antibiotics are considered the drugs of choice for the treatment of ESBL -producing Enterobacteriaceae and other multidrug resistant bacteria.
11p quenchua2 18-12-2019 10 0 Download
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Over the period of years infections caused by multidrug resistance organisms has emerged as a major public health problem. Their prevalence rates vary in different parts of the world and hence local data regarding these pathogens were important. Our study was aimed to identify the presence of ESBL and AmpC producing Enterobacteriaceae isolates from various clinical samples in our hospital setup various clinical samples were processed consecutively during the study period for microbiological analysis as per standard operating procedure.
9p quenchua2 16-12-2019 21 1 Download