Multidrug therapy

Patients with hematological malignancies often require multidrug therapy using a variety of antineoplastic agents and supportive care medications. This increases the risk of drug-related problems (DRPs). Determining DRPs in patients hospitalized in hematology services is important for patients to achieve their drug treatment goals and prevent adverse effects.

8p vishanshan 27-06-2024 2 1   Download

This volume offers a comprehensive overview of basic and applied aspects of Staphylococcus aureus, which is one of the most important human pathogens. It includes sixteen chapters that address the microbiology and immunology of S. aureus, the pathology of its key manifestations, and the current standard of care. Further, it reviews cutting-edge advances in alternative therapeutic and prophylactic approaches to antibiotics.

543p vimeyers 29-05-2024 2 2   Download

Ebook "Breast cancer chemosensitivity" include in-depth discussions on multidrug resistance by P-glycoprotein and the multidrug resistance protein family, resistance to therapeutic agent-induced apoptosis, cell cycle deregulation, deregulation of DNA repair, loss of tumor suppressor genes, integrin-mediated adhesion, insulin-like growth factors, epidermal growth factor, and ErbB2 in modulating breast cancer response to systemic therapy, especially, certain chemotherapeutic agents.

187p tracanhphuonghoa1007 22-04-2024 3 1   Download

Methicillin-resistant Staphylococcus aureus (MRSA) is a global health concern. Many antibiotics are no longer effective at treating MRSA, which causes an increase in adverse patient outcomes. This has led to calls for new antibiotics and treatment strategies to combat the spread of MRSA and multidrug resistance (MDR).

9p vimalfoy 08-02-2023 3 2   Download

This study was conducted to present and to analize the trends in case detection and prevalence of leprosy in Vietnam from 1983 to 2018. Individual records and annual reports were collected to analyze information of the prevalence of registered cases, the numbers of new cases detected yearly, their sex, age, classification and disability status.

10p caygaocaolon11 18-04-2021 14 2   Download

Pneumonia and septic pneumonic shock are the most common indications for long-term mechanical ventilation and prolonged weaning, independent of any comorbidities. Multidrug resistant (MDR) bacteria are emerging as a cause of pneumonia or occur as a consequence of antimicrobial therapy.

8p vimontana2711 05-04-2021 15 2   Download

Tuberculosis is an infectious bacterial disease caused by Mycobacterium tuberculosis. It remains a major health threat, killing over one million people every year worldwide. An early antibiotic therapy is the basis of the treatment, and the emergence and spread of multidrug and extensively drug-resistant mutant strains raise significant challenges.

9p vikentucky2711 26-11-2020 10 2   Download

The study included 150 patients admitted in burns unit at Osmania General Hospital, Hyderabad over a period of six months from March 2015 to August 2015. The wound swabs collected were sent to Microbiology lab for Grams stain, Culture and Antimicrobial susceptibility. Majority of the cases were in the age group 20- 30 yrs. Females outnumbered males. Burns due to flames were the most common cause of the wound. Among 150 samples, 143 were culture positive of which, Staphylococcus aureus (S. aureus) was the predominant isolate followed by Klebsiella.

8p nguaconbaynhay6 23-06-2020 26 2   Download

Surgical site infections are most common nosocomial infection and are associated with prolonged hospital stay, health care cost, morbidity and mortality. The causative agents involved in SSI’s may vary with geographical location, between surgeons, various procedures and from hospital to hospital. The present study was done to determine the aerobic bacterial flora from surgical site infections and their antimicrobial resistance pattern. A total of 50 culture positive samples obtained from SSI’s were included in this study.

9p trinhthamhodang3 12-02-2020 24 0   Download

Resistance in pathogenic bacteria against antibiotics is a challenge for our clinicians for the management of various infections. The emergence of antibiotic resistance has caused great concern among health professionals and the prevalence of multidrug-resistant organisms has been increasing. Over-ambitious use of broad spectrum antibiotics is playing an important role in the increased incidence of infections due to MDR bacteria. Multiple drug resistance (MDR) mediated through R plasmids among Gram-negative bacteria has become a major nosocomial problem worldwide.

5p nguaconbaynhay3 07-02-2020 32 1   Download

The rapid emergence of multiresistant microbial pathogens is a serious threat to human health. Extended spectrum beta lactamase (ESBL)-producing Escherichia coli is a superbug causing worldwide outbreaks, CTX-M has become the most commonly detected ESBL genotype; these enzymes have become predominant worldwide, the most common type of CTX-M reported in various geographic regions is CTX-M15. A total of 80 Escherichia coli (E. coli) isolates were recovered from different clinical samples of intensive care units (ICUs) patients.

13p nguathienthan2 26-12-2019 17 1   Download

Historically, S. aureus has been one of the most common pathogens which caused pyogenic local and systemic infections in both hospitals and community. Methicillin resistance in Staphylococcus aureus is associated with multidrug resistance, an aggressive course, increased mortality and morbidity in both community and health care facilities. This cross sectional study was carried out in a 70 burn patients from May 2016 to July 2018 at DR.S.C.G.M.C, Nanded India. Swabs were taken and cultured for bacterial isolation and identification following standard operative procedures.

6p chauchaungayxua1 04-12-2019 25 2   Download

Pharmacokinetic drug–drug interactions (in particular at metabolism) may result in fatal adverse effects in some cases. This basic information, therefore, is needed for drug therapy even in veterinary medicine, as multidrug therapy is not rare in canines and felines. The aim of this review was focused on possible drug–drug interactions in dogs and cats. The interaction includes enzyme induction by phenobarbital, enzyme inhibition by ketoconazole and flu- oroquinolones, and down-regulation of enzymes by dexamethasone.

10p trinhthamhodang1 16-11-2019 15 0   Download

Multidrug resistance is a major challenge in the therapy of cancer and pathogenic fungal infections. More than three decades ago, P-glycoprotein was the first identified multidrug transporter. It has been studied exten-sively at the genetic and biochemical levels ever since. Pdr5, the most abun-dant ATP-binding cassette transporter in Saccharomyces cerevisiae,is highly homologous to azole-resistance-mediating multidrug transporters in fungal pathogens, and a focus of clinical drug resistance research. ...

10p mobifone23 18-01-2013 36 3   Download

The acquisition of multidrug resistance in bacteria underlies the failure of antimicrobial therapy, and the emergence of pathogens that are resistant to almost the entire armoury of antibiotics.

10p cosis54 09-12-2012 38 1   Download

The physician is greatly challenged to provide optimal therapy for mycobacterial illnesses because of the increase in both drug-susceptible and multidrug-resistant tuberculosis; the increasing number of pathogenic nontuberculous mycobacteria (NTM); drug-related toxicities and drug-drug interactions (especially in patients who have AIDS, with their complex antiretroviral drug regimens); and the plethora of new antibiotics with antimycobacterial potential.

19p crazy_sms 08-05-2012 63 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: HIV-1 mutational pathways under multidrug therapy...

13p toshiba23 18-11-2011 35 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Risk factors for multidrug resistant bacteria and optimization of empirical antibiotic therapy in postoperative peritonitis...

8p coxanh_6 30-10-2011 35 3   Download

Table 86-3 Suggested Approaches to Adjuvant Therapy Age Group h Lymp Endocr Tum tion Recommenda Node ine Receptor or (ER) Status Statusa Premenopa usal ve Positi Any Any Multidrug chemotherapy tamoxifen positive if + ER+ trastuzumab in HER- 2/neu tumors positive Premenopa usal ive Negat Any 2 Multidrug + ER+ cm, or 1–2 chemotherapy cm with tamoxifen if other poor positive prognostic trastuzumab in HERvariables 2/neu tumors positive Postmenopa usal ve Positi e Negativ Any Multidrug chemotherapy + trastuzumab in HER2/neu tumors positive Postmenopa usal ve Pos...

5p konheokonmummim 03-12-2010 311 3   Download