Multifactorial disease

. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.

10p dianmotminh02 03-05-2024 7 3   Download

Rheumatoid arthritis is a multifactorial disease characterized by chronic inflammation of the joints. Both genetic and environmental factors are involved in the pathogenesis leading to joint destruction and ultimately dis-ability. In the inflamed RA joint the synovium is highly infiltrated by CD4 + T cells, B cells and macrophages, and the intimal lining becomes hyperplastic owing to the increased number of macrophage-like and fibro-blast-like synoviocytes.

8p galaxyss3 07-03-2013 35 2   Download

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Family-based genetic risk prediction of multifactorial disease

7p panasonic02 15-12-2011 41 3   Download

Abstract Retinopathy of prematurity (ROP) is a vascular vitreoretinopathy that affects infants with short gestational age and low birth-weight. The condition is a multifactorial disease and is clinically similar to familial exudative vitreoretinopathy (FEVR), which is a bilateral hereditary eye disorder affecting full-term infants. Both of them are characterized by the abnormal vessel growth in the vitreous that can lead to vitreoretinal traction, retinal detachment and other complications resulting in blindness.

7p toshiba23 18-11-2011 45 2   Download

Table 62-8 Genetic Approaches for Identifying Disease Genes Method Indications Advantages and Limitations Linkage Studies Classical linkage analysis Analysis of Difficult to collect (parametric monogenic traits large informative pedigrees methods) Suitable for genome scan Difficult to obtain sufficient statistical power for complex traits Control not required population Useful for multifactorial disorders in isolated populations Allele-sharing Suitable for Difficult to collect methods (nonparametric identification methods) susceptibility genes of sufficient nu...

5p konheokonmummim 03-12-2010 81 5   Download

Complex Genetic Disorders The expression of many common diseases such as cardiovascular disease, hypertension, diabetes, asthma, psychiatric disorders, and certain cancers is determined by a combination of genetic background, environmental factors, and lifestyle. A trait is called polygenic if multiple genes contribute to the phenotype or multifactorial if multiple genes are assumed to interact with environmental factors. Genetic models for these complex traits need to account for genetic heterogeneity and interactions with other genes and the environment.

7p konheokonmummim 03-12-2010 70 4   Download

Neoplastic disease In most cases, the cause of cancer is multifactorial. About 75% of cancers are due to environmental factors, some of which are within the control of the individual, e.g. tobacco smoking, exposure to sunlight. Growing understanding of cancer genetics and inherited disease suggests that fewer than 10% of cancers are familial.The different systemic modalities used to treat cancer patients are discussed. Immunosuppressive drugs are described here as they share many characteristics with cytotoxics. ...

19p bigbaby87 03-09-2010 101 11   Download