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Multifactorial disease
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. In vitro biological evaluation revealed the most active compound 4d with an inhibitory concentration of 42.87 μM against K562 and 47.42 μM on A549 cells. The anticancer activity of this naphthylidene isoxazolidinedione derivative was evident by cell cycle and apoptosis assays, which showed arrest of the G2/M phase (65.6%) of the K562 cells and induction of apoptosis with 21.47% apoptotic cells as compared to 0.2% of untreated cells, respectively.
10p
dianmotminh02
03-05-2024
2
2
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Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a severe neuropsychiatric disorder that is characterized by psychosis as well as multifactorial medical co-morbidities, including metabolic disease, contributing to markedly increased morbidity and mortality.
19p
vibransone
28-03-2024
7
2
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Congenital heart disease (CHD) occurs in almost 1% of newborn children and is considered a multifactorial disorder. CHD may segregate in families due to significant contribution of genetic factors in the disease etiology. The aim of the study was to identify pathophysiological mechanisms in families segregating CHD.
13p
vibransone
28-03-2024
4
2
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Type 2 diabetes (T2D), a multifactorial disease influenced by host genetics and environmental factors, is the most common endocrine disease. Several studies have shown that the gut microbiota as a close-up environmental mediator influences host physiology including metabolism. The aim of the present study is to examine the compositional and functional potential of the gut microbiota across individuals from Denmark and South India with a focus on T2D.
13p
vibransone
28-03-2024
3
2
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Part 2 book "Large animal neurology" includes content: Congenital, familial and genetic disorders; infectious, inflammatory and immune diseases; physical, chemical and thermal causes; toxic diseases; nutritional diseases; metabolic diseases; neoplasms and other tumors; multifactorial and idiopathic disorders,... and other contents.
384p
muasambanhan07
20-02-2024
2
0
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Ebook Clinical management in psychodermatology: Part 1 includes content: Primarily psychogenic dermatoses, multifactorial cutaneous diseases, secondary emotional, cosmetic medicine, psychosomatic dermatology in emergency medicine, andrology,… and other contents.
162p
longtimenosee03
01-02-2024
1
0
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Part 1 book "Genetics in medicine" includes content: Introduction, introduction to the human genome, the human genome, human genetic diversity - mutation and polymorphism, principles of clinical cytogenetics and genome analysis, the chromosomal and genomic basis of disease - disorders of the autosomes and sex chromosomes, patterns of single gene inheritance, complex inheritance of common multifactorial disorders, genetic variation in populations, identifying the genetic basis for human disease.
197p
oursky09
08-11-2023
6
2
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Nephrogenic ascites is described as a clinical condition of refractory ascites in patients with end-stage renal disease (ESRD) on renal replacement therapy. This entity was first described in 1970. Many nephrologists do not believe in nephrogenic ascites. The underlying etiologies can be multifactorial including a combination of poor nutrition, inadequate dialysis and ultrafiltration, increased peritoneal membrane permeability, and overall uremia.
4p
viintuit
26-09-2023
2
0
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Part 2 book "Medical genetics" includes contents: Disease gene identification, immunogenetics, cancer genetics, genetic basis of development, multifactorial inheritance and common diseases, genetic testing and gene therapy, genetics and precision medicine, clinical genetics and genetic counseling.
206p
oursky01
17-07-2023
2
0
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Reproductive impairment in men is a multifactorial disease and is currently considered a global health issue. Previous studies have investigated the correlation between genetic variants and male infertility in different populations. However, such studies have appeared in limited amounts in the Vietnamese population.
9p
vicaptainmarvel
21-04-2023
4
2
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Diabetes and obesity are multifactorial diseases caused by a complex interaction of environmental and genetic factors, with the latter consisting of multiple susceptibility genes, making it difficult to clarify their functions and interactions in conferring susceptibility to diabetes and obesity in humans.
10p
vinarcissa
21-03-2023
2
1
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Nonalcoholic fatty liver disease (NAFLD) is a multifactorial disease caused by interactions between environmental and genetic factors. The SMXA-5 mouse is a high-fat diet-induced fatty liver model established from SM/J and A/J strains. We have previously identified Fl1sa, a quantitative trait locus (QTL) for fatty liver on chromosome 12 (centromere-53.06 Mb) of SMXA-5 mice.
10p
vinarcissa
21-03-2023
1
1
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Biological pathways play an important role in the occurrence, development and recovery of complex diseases, such as cancers, which are multifactorial complex diseases that are generally caused by mutation of multiple genes or dysregulation of pathways.
12p
vihagrid
30-01-2023
6
3
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The article presents for the first time data on the frequency of two important “slow” variants of NAT2 gene (NAT2*5, rs1801280 and NAT2*7, rs1799931), which significantly affect the rate of xenobiotics acetylation, among representatives of indigenous populations of Forest and Tundra Nenets in Northern Siberia.
7p
vihagrid
30-01-2023
5
3
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Tobacco consumption, as a worldwide problem, is a risk factor for several types of cancer. In Vietnam, tobacco consumption in the form of waterpipe tobacco smoking is common. This prospective cohort study aimed to study the association between waterpipe tobacco smoking and gastric cancer mortality in Northern Vietnam.
11p
viangelamerkel
27-07-2022
6
4
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Feline chronic gingivostomatitis (FCGS) is a multifactorial immune-mediated disease that can lead to chronic pain, anorexia, and weight loss and has substantial health and welfare effects. Currently, the recommended treatment includes dental extractions to decrease the inflammatory stimulation associated with dental plaque.
9p
vigandhi
23-02-2022
6
1
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Systemic lupus erythematosus (SLE) is a clinically heterogeneous autoimmune disease characterized by the development of anti-nuclear antibodies. Susceptibility to SLE is multifactorial, with a combination of genetic and environmental risk factors contributing to disease development.
26p
viarchimedes
26-01-2022
9
0
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Chronic back pain is a multifactorial disease that occurs particularly in adults and has many negative effects on the quality of daily life. Therapeutic strategies are often multimodal and designed for a long-term therapy period. In some cases, one option is joint infiltration or intrathecal injection with local anaesthetics. An adverse effect of this intervention may be necrotic fasciitis, a disease with high mortality and few therapeutic options.
4p
vizhangzhidong
29-12-2021
4
0
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Low pass sequencing has been proposed as a cost-effective alternative to genotyping arrays to identify genetic variants that influence multifactorial traits in humans. For common diseases this typically has required both large sample sizes and comprehensive variant discovery.
7p
vilichoo2711
23-06-2021
17
1
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Musculoskeletal disorders are the most frequent occupational diseases in Europe. However, their multifactorial aetiology poses several challenges concerning not only the estimation of relative prevalence rates across occupational groups but also how the co-occurrence of known risk factors might differ between disorders of the upper and lower limbs.
11p
viannito2711
20-04-2021
11
1
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