Multiple molecular

Cyclin B2 (CCNB2), a member of the cyclin family, is an oncogene in multiple cancers, including nasopharyngeal carcinoma (NPC). However, the epigenetics mechanism for CCNB2 overexpression in NPC remains unclear. This study dissects the regulatory role of CCNB2 in NPC and the molecular mechanism.

14p vishanshan 27-06-2024 2 1   Download

Ebook "Introduction to computational biology: An evolutionary approach" Analysis of molecular sequence data is the main subject of this introduction to computational biology. There are two closely connected aspects to biological sequences: (i) their relative position in the space of all other sequences, and (ii) their movement through this sequence space in evolutionary time. Accordingly, the first part of the book deals with classical methods of sequence analysis: pairwise alignment, exact string matching, multiple alignment, and hidden Markov models.

329p tracanhphuonghoa1007 22-04-2024 10 2   Download

Ebook "The cell biology of stem cells" deals with multiple aspects of stem cell biology, ranging from their basic molecular characteristics to the in vivo stem cell trafficking of adult stem cells and the adult stem-cell niche, and ends with a visit to regeneration and cell fate reprogramming.

246p tracanhphuonghoa1007 22-04-2024 2 2   Download

Ebook "Studies of photoinduced molecular dynamics using a fast imaging sensor" presented in this thesis involves a number of sophisticated experiments highlighting novel applications of the Pixel Imaging Mass Spectrometry (PImMS) camera in the field of photoinduced molecular dynamics. This approach represents the union of a new enabling technology (a multiple memory register, CMOS-based pixel detector) with several modern chemical physics approaches and represents a significant leap forward in capabilities.

194p tracanhphuonghoa1007 22-04-2024 5 3   Download

Genome wide association studies have identified > 200 susceptibility loci accounting for much of the heritability of multiple sclerosis (MS). Epstein-Barr virus (EBV), a memory B cell tropic virus, has been identified as necessary but not sufficient for development of MS. The molecular and immunological basis for this has not been established.

13p vibransone 28-03-2024 4 1   Download

Genomic structural variants (SVs) can affect many genes and regulatory elements. Therefore, the molecular mechanisms driving the phenotypes of patients carrying de novo SVs are frequently unknown.

15p vibransone 28-03-2024 5 2   Download

Gastric cancer is among the most lethal human malignancies. Previous studies have identified molecular aberrations that constitute dynamic biological networks and genomic complexities of gastric tumors. However, the clinical translation of molecular-guided targeted therapy is hampered by challenges. Notably, solid tumors often harbor multiple genetic alterations, complicating the development of effective treatments.

12p vibransone 28-03-2024 6 2   Download

Patterns in expression data conserved across multiple independent disease studies are likely to represent important molecular events underlying the disease. We present the INSPIRE method to infer modules of co-expressed genes and the dependencies among the modules from multiple expression datasets that may contain different sets of genes.

31p vioraclene 31-03-2024 4 2   Download

Tuberous sclerosis complex (TSC) is a genetic disease characterized by benign tumor growths in multiple organs and neurological symptoms induced by mTOR hyperfunction. Because the molecular pathology is highly complex and the etiology poorly understood, we employed a defined human neuronal model with a single mTOR activating mutation to dissect the disease-relevant molecular responses driving the neuropathology and suggest new targets for treatment.

14p vioraclene 31-03-2024 2 1   Download

Germline chromothripsis causes complex genomic rearrangements that are likely to affect multiple genes and their regulatory contexts. The contribution of individual rearrangements and affected genes to the phenotypes of patients with complex germline genomic rearrangements is generally unknown.

14p vioraclene 31-03-2024 2 2   Download

Ebook "Functional molecular silicon compounds I: Regular oxidation states" critical reviews on topics of research concerned with chemical structure and bonding. The scope of the series spans the entire Periodic Table and addresses structure and bonding issues associated with all of the elements. It also focuses attention on new and developing areas of modern structural and theoretical chemistry such as nanostructures, molecular electronics, designed molecular solids, surfaces, metal clusters and supramolecular structures.

242p tudohanhtau1006 29-03-2024 3 1   Download

In ebook "Molecular biology" plant biology is considered from the perspective of plants and their surrounding environment, including both biotic and abiotic interactions. The intended audience is undergraduate students in the middle or final phases of their programs of study.

427p cotieubac1004 15-03-2024 5 0   Download

Ebook "Advances in biology and therapy of multiple myeloma - Volume 1: Basic science" despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients.

322p duongthandue0501 28-02-2024 3 1   Download

Ebook "Computational modeling of biological systems: From molecules to pathways" provides an overview of the established computational methods used for modeling biologically and medically relevant systems. Computational modeling is emerging as a powerful new approach to study and manipulate biological systems. Multiple methods have been developed to model, visualize, and rationally alter systems at various length scales, starting from molecular modeling and design at atomic resolution to cellular pathways modeling and analysis.

360p duongthandue0501 28-02-2024 6 1   Download

The rapid advancement of single-cell transcriptomics in neurology has allowed for profiling of post-mortem human brain tissue across multiple diseases. Over the past 3 years, several studies have examined tissue from donors with and without diagnoses of Alzheimer’s disease, highlighting key changes in cell type composition and molecular signatures associated with pathology and, in some cases, cognitive decline.

13p vicwell 29-02-2024 3 1   Download

Ebook "The families and genera of vascular plants - Volume XIII: Flowering plants, monocots (Poaceae)" is the outcome of a modern phylogenetic analysis of the grass family based on multiple sources of data, in particular molecular systematic studies resulting from a concerted effort by researchers worldwide, including the author. In the classification given here grasses are subdivided into 12 subfamilies with 29 tribes and over 700 genera. The keys and descriptions for the taxa above the rank of genus are hierarchical, i.e.

413p manmanthanhla0201 26-02-2024 3 1   Download

Part 1 book "An introduction to chemical engineering kinetics and reactor design" includes content: Stoichiometric coefficints and reaction progress variables; thermodynamics of chemical reactions; basic concepts in chemical kinetics determination of the reaction rate expression; basic concepts in chemical kinetics - molecular interpretations of kinetic phenomena; chemical systems involving multiple reactions; elements of heterogeneous catalysis; liquid phase reactions; basic concepts in reactor design and ideal reactor models

325p muasambanhan06 03-02-2024 4 1   Download

Breast cancer is an umbrella term referring to a group of biologically and molecularly heterogeneous diseases originating from the breast. Globally, incidences of breast cancer has been increasing dramatically over the past decades.

9p vileonardodavinci 23-12-2023 6 4   Download

Cantharidin (CTD) is the active ingredient of Chinese medicine, which has been traditionally used in multiple cancers treatment, especially in hepatocellular carcinoma (HCC). However, a comprehensive analysis of the CTD-related molecular mechanism is still necessary to understand its functions in HCC treatment. This study aimed to reveal the novel molecular targets and regulatory networks of CTD in HCC.

14p vileonardodavinci 23-12-2023 6 2   Download

Osteosarcoma (OS) is one of the malignant bone tumors with strong aggressiveness and poor prognosis. Leucine-rich repeats and immunoglobulin-like domains2 (LRIG2) is closely associated with the poor prognosis of a variety of tumors, but the role of LRIG2 in osteosarcoma and the underlying molecular mechanism remains unclear.

10p vialfrednobel 23-12-2023 6 3   Download