Multiple signal pathways
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Ebook "Shh and Gli signalling and development" rep resents a concerted drive to bring together *state of the art' reviews by lead ing experts in the field of Shh and Gli signalling in development from all over the world. The chapters span vertebrate organisms from zebrafish to humans and cover development of the multiple organ systems in which the Shh signalling pathway is crucial for normal development.
169p tracanhphuonghoa1007 22-04-2024 1 1 Download
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Wnt signaling is an evolutionarily conserved developmental pathway that is frequently hyperactivated in cancer. While multiple protein-coding genes regulated by Wnt signaling are known, the functional lncRNAs regulated by Wnt signaling have not been systematically characterized.
22p vibransone 28-03-2024 2 2 Download
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Mutations in the p110α catalytic subunit of phosphatidylinositol 3-kinase (PI3K), encoded by the PIK3CA gene, cause dysregulation of the PI3K pathway in 35–40% of patients with HR+/HER2– breast cancer.
14p vicwell 29-02-2024 7 1 Download
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In ebook "Applications of mass spectrometry in life safety" The potential of MS for high-sensitive structural a- lyses became unsurpassable after the introduction of electrospray (ESI) and matrix assisted laser/desorption ionization (MALDI) methods, on one hand, and the pos- bility to deduce in detail unknown biopolymer structures by highly accurate mo- cular mass measurement followed by sequencing using dissociation techniques based on multiple stage MS, on the other.
238p manmanthanhla0201 27-02-2024 2 1 Download
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The biguanide metformin has been shown to not only reduce circulating glucose levels but also suppress in vitro and in vivo growth of prostate cancer. However, the mechanisms underlying the anti-tumor effects of metformin in advanced prostate cancers are not fully understood.
12p vialfrednobel 23-12-2023 4 3 Download
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The protein kinase C (PKC) family of serine/threonine kinases contains more than ten isozymes that are involved in multiple signaling pathways, including cell cycle regulation and carcinogenesis.
7p vischultz 20-10-2023 3 1 Download
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Colitis-associated colon cancer (CAC) patients have a younger age of onset, more multiple lesions and invasive tumors than sporadic colon cancer patients. Early detection of CAC using endoscopy is challenging, and the incidence of septal colon cancer remains high.
13p vihagrid 30-01-2023 7 3 Download
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The overexpression of aberrant cell cycle signalling pathway associated protein has been implicated in multiple malignancies and the identification of all-important one among is the crux of the precise targeted therapy.
11p visusanwojcicki 28-06-2022 6 2 Download
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Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer (BC). Treatment options for TNBC patients are limited and further insights into disease aetiology are needed to develop better therapeutic approaches. microRNAs’ ability to regulate multiple targets could hold a promising discovery approach to pathways relevant for TNBC aggressiveness.
19p vielonmusk 21-01-2022 10 0 Download
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Since plants are exposed to diverse environmental stresses in their natural area, numerous reviews have demonstrated many aspects of dehydrins (DHNs), including structural and functional dynamics, and multiple roles such as membrane protection, cryoprotection of enzymes, chaperone feature, and protection from reactive oxygen species. In this review, we have focused on new information, and other promising and emerging topics of DHNs in plants.
12p tudichquannguyet 29-11-2021 12 1 Download
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Adenovirus protein, Gam1, triggers the proteolytic destruction of the E1 SUMO-activating enzyme. Microinjection of an empirically determined amount of Gam1 mRNA into one-cell Xenopus embryos can reduce SUMOylation activity to undetectable, but nonlethal, levels, enabling an examination of the role of this posttranslational modification during early vertebrate development.
19p visilicon2711 20-08-2021 7 1 Download
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Histone post-translational modifications play crucial roles in epigenetic regulation of gene expression and are known to be associated with the phenotypic differences of different cell types. Therefore, it is of fundamental importance to dissect the genes and pathways involved in such a phenotypic variation at the level of epigenetics.
19p vijeeni2711 24-07-2021 8 1 Download
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Albino mutations are commonly observed in the animal kingdom, including in bivalves. In the blacklipped pearl oyster Pinctada margaritifera, albino specimens are characterized by total or partial absence of colouration resulting in typical white shell phenotype expression.
13p vijeeni2711 30-06-2021 11 2 Download
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Side population (SP) cells, which have similar features to those of cancer stem cells, show resistance to dexamethasone (Dex) treatment. Thus, new drugs that can be used in combination with Dex to reduce the population of SP cells in multiple myeloma (MM) are required.
10p vianrose2711 27-04-2021 15 1 Download
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Src homology 2 containing protein tyrosine phosphatase (PTP) 2 (Shp2) is a typical tyrosine phosphatase interacting with receptor tyrosine kinase to regulate multiple signaling pathways in diverse pathological processes. Here, we will investigate the effect of Shp2 inhibition on pulmonary arterial hypertension (PAH) in a rat model and its potential cellular and molecular mechanisms underlying.
10p vimontana2711 05-04-2021 11 3 Download
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Regulation of organ and body size is a fundamental biological phenomenon, requiring tight coordination between multiple tissues to ensure accurate proportional growth. In C. elegans, a TGF-β pathway is the major regulator of body size and also plays a role in the development of the male tail, and is thus referred to as the TGF-β/Sma/Mab (for small and male abnormal) pathway.
13p vimariana2711 22-12-2020 12 1 Download
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In multiple vertebrate organisms, including chick, Xenopus, and zebrafish, Fibroblast Growth Factor (FGF) and Wnt signaling cooperate during formation of the otic placode. However, in the mouse, although FGF signaling induces Wnt8a expression during induction of the otic placode, it is unclear whether these two signaling pathways functionally cooperate.
15p viwyoming2711 16-12-2020 7 0 Download
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The Hedgehog (Hh) signaling pathway, acting through three homologous transcription factors (GLI1, GLI2, GLI3) in vertebrates, plays multiple roles in embryonic organ development and adult tissue homeostasis. At the level of the genome, GLI factors bind to specific motifs in enhancers, some of which are hundreds of kilobases removed from the gene promoter.
11p viwyoming2711 16-12-2020 13 1 Download
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Signaling pathways play important roles in the life processes of cell growth, cell apoptosis and organism development. At present the signal transduction networks are far from complete. As an effective complement to experimental methods, computational modeling is suited to rapidly reconstruct the signaling pathways at low cost.
18p vioklahoma2711 19-11-2020 7 1 Download
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Often researchers are interested in comparing multiple experimental groups (e.g. tumor size) with a reference group (e.g. normal tissue) on the basis of thousands of features (e.g. genes) and determine if a differentially expressed feature is up or down regulated in a pairwise comparison.
12p vioklahoma2711 19-11-2020 13 1 Download