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Mutant mice
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Ebook "Tight junctions" highlight the importance of understanding TJ physiology in order to develop effective strategies for the treatment of pathological conditions such as cancer and autoimmune diseases. The first chapter of this book describes the evolution of the transporting epithelium from primitive metazoans to mammalian epithelia. Then, Chapters 2, 3, 4, 5, 6 and 7 review the characteristics and functionality of difi^erent proteins of theTJ studied in cell culture models, natural epithelia, mutant mice and heritable human diseases.
235p
ladongphongthanh1008
22-04-2024
5
2
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Part 2 book "Transgenic mouse - Methods and protocols" includes content: Introduction - Engineering BAC reporter gene constructs for mouse transgenesis; targeting vector construction through recombineering; generating conditional knockout mice; hypomorphic mice; micer targeting vectors for manipulating the mouse genome; knock in approaches; generation of a series of knock in alleles using rmce in es cells; selection of targeted mutants from a library of randomly mutagenized ES cells.... and other contents.
190p
oursky09
12-11-2023
8
3
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Part 2 book "Transgenic mouse, methods and protocols" includes content: Engineering BAC reporter gene constructs for mouse transgenesis; targeting vector construction through recombineering, generating conditional knockout mice, hypomorphic mice, knock in approaches, selection of targeted mutants from a library of randomly mutagenized ES cells,...and other contents.
190p
oursky05
20-09-2023
2
2
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During hair growth, cortical cells emerging from the proliferative follicle bulb rapidly undergo a differentiation program and synthesize large amounts of hair keratin proteins. In this process, HOXC13 is one critical regulatory factor, proved by the hair defects in HOXC13 mutant mice and HOXC13 mutant patients. However, inconsistent conclusions were drawn from previous researches regarding the regulation of HOXC13 on different keratins. Whether HOXC13 has extensive and unified regulatory role on these numerous keratins is unclear.
16p
vitzuyu2711
29-09-2021
12
1
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Primary cilia are essential for Hedgehog (Hh) signal transduction in vertebrates. Although the core components of the Hh pathway are highly conserved, the dependency on cilia in Hh signaling is considered to be lower in fish than in mice, suggesting the presence of species-specific mechanisms for Hh signal transduction.
11p
viwyoming2711
16-12-2020
12
1
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Systematic, standardized and in-depth phenotyping and data analyses of rodent behaviour empowers gene-function studies, drug testing and therapy design. However, no data repositories are currently available for standardized quality control, data analysis and mining at the resolution of individual mice.
5p
vioklahoma2711
19-11-2020
39
0
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In neuroscience research, mouse models are valuable tools to understand the genetic mechanisms that advance evidence-based discovery. In this context, large-scale studies emphasize the need for automated high-throughput systems providing a reproducible behavioral assessment of mutant mice with only a minimum level of manual intervention.
14p
viflorida2711
30-10-2020
21
2
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Lung cancer is the number one cancer killer worldwide. A major drawback in the lung cancer treatment field is the lack of realistic mouse models that replicate the complexity of human malignancy and immune contexture within the tumor microenvironment.
10p
vimale2711
21-08-2020
13
1
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Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related death worldwide with limited treatment options. Mutation of β-catenin is one of the most frequent genetic events along hepatocarcinogenesis. β-catenin mutations can be in the form of point mutation or large N-terminal deletion. Studies suggested that different β-catenin mutations might have distinct oncogenic potential.
11p
vimanila2711
25-06-2020
10
1
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To directly assess the biological role of oligosaccharides in recombinant equine chorionic gonadotropin (rec-eCG) functioning, cDNA encoding the full-length eCGβ-subunit was fused with the mature protein part of the αsubunit, and we examined the expression levels of deglycosylated eCG mutants, the ovulation rate for deglycosylated mutants in C57BL/6 mice.
9p
vihamax2711
21-04-2020
18
0
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Fructose 2,6-bisphosphate (Fru-2,6-P2 ) plays an important role in the regulation of major carbohydrate fluxes as both allosteric activator and inhibitor of target enzymes. To examine the role of Fru-2,6-P2in the regulation of hepatic carbohydrate metabolism in vivo,Fru-2,6-P2 levels were elevated in ADM mice with adenovirus-mediated overex-pression of a double mutant bifunctional enzyme, 6-phos-phofructo-2-kinase/fructose-2,6-bisphosphatase (n¼6), in comparison to normal control mice (control,n¼6). ...
9p
research12
29-04-2013
48
3
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Alcohol dehydrogenase (ADH) deficiency results in decreased retinol utilization, but it is unclear what physio-logical roles the several known ADHs play in retinoid signaling. Here, Adh1, Adh3,andAdh4null mutant mice have been examined following acute and chronic vitamin A excess. Following an acute dose of retinol (50 mgÆkg )1 ), metabolism of retinol to retinoic acid in liver was reduced 10-fold inAdh1mutants and 3.8-fold inAdh3mutants, but was not significantly reduced inAdh4mutants.
6p
research12
29-04-2013
50
2
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Cdx-2 is a transactivator for the proglucagon gene in pancreatic and intes-tinal endocrine cells. Cdx-2 is also expressed in differentiated intestinal epi-thelia of nonendocrine origin. Cdx-2 –⁄ – mice are embryonic lethal, while Cdx-2 +⁄ – mutants show multiple malfunctions including the formation of intestinal polyps.
14p
awards
06-04-2013
47
3
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We have shown that quetiapine, a new antipsychotic drug, protects cultured cells against oxidative stress-related cytotoxicities induced by amyloidb (Ab)25-35, and that quetiapine prevents memory impairment and decreases Abplaques in the brains of amyloid precursor protein (APP)⁄presenilin-1 (PS-1) double-mutant mice.
11p
galaxyss3
07-03-2013
28
2
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The orphan receptors, Rev-erba and Rev-erbb, are members of the nuclear receptor superfamily and specifically repress apolipoprotein CIII (apoCIII) gene expression in rats and humans. Moreover, Rev-erbanull mutant mice have elevated very low density lipoprotein triacylglycerol and apoCIII levels.
12p
media19
04-03-2013
32
1
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Thyroid hormone receptors (TRs) play a major role in animal physiology. TRs are important and very interesting regulators of diverse aspects, including brain development, hearing, bone growth, morphogenesis, metabolism, intestine, and heart rate in vertebrates (Fig. 1). Aberrant functions of TRs induce tremendous defects in these pathways. For example, the human disease of Resistance to Thyroid Hormone (RTH) (see Chapter 8 by Yoh and Privalsky) is a genetically autosomal dominant inherited syndrome that is caused by mutations in the gene encoding the TRβ.
213p
echbuon
02-11-2012
53
6
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Herpes simplex virus type-1(HSV-1) oncolytic and highly fusogenic mutants carrying the NV1020 genomic deletion effectively inhibit primary and metastatic tumors in mice
10p
dauphong7
13-01-2012
55
2
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Increased circulating leukocyte numbers and altered macrophage phenotype correlate with the altered immune response to brain injury in metallothionein (MT) -I/II null mutant mice
11p
panasonic09
12-01-2012
44
4
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Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes
16p
panasonic09
12-01-2012
41
3
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: SCN-AVP release of mPer1/mPer2 double-mutant mice in vitro...
10p
thulanh23
21-11-2011
34
3
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