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Myeloproliferative neoplasms
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In the pathogenesis of myeloproliferative neoplasms (MPN), inflammation plays an important role. However, it is unclear whether there is a causal link between inflammation and MPNs. We used a bidirectional, two-sample Mendelian randomization (MR) approach to investigate the causal relationship between systemic inflammatory cytokines and myeloproliferative neoplasms.
12p
vishanshan
27-06-2024
1
1
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Primary myelofibrosis [PMF] is a myeloproliferative neoplasm associated with reduced overall survival (OS). Management strategies for PMF have evolved over the last two decades, including approval of ruxolitinib as the first Janus kinase 1 (JAK1)/JAK2 inhibitor for patients with intermediate or high-risk myelofibrosis. This study assessed changes in mortality before and after ruxolitinib approval, independent of ruxolitinib treatment.
8p
vileonardodavinci
23-12-2023
3
2
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Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) comprise several rare hematologic malignancies with shared concomitant dysplastic and proliferative clinicopathologic features of bone marrow failure and propensity of acute leukemic transformation, and have significant impact on patient quality of life.
15p
vialfrednobel
23-12-2023
6
4
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This study aims to determine environmental, lifestyle, genetic and medical causes of MPNs and to assess the relevance of occupational carcinogen exposures and quality of life impacts.
9p
vialfrednobel
23-12-2023
5
4
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Part 2 book "Veterinary comparative hematopathology" includes content: T-Cell and NK-Cell neoplasms, acute myeloid leukemias, chronic myeloproliferative diseases, myeloproliferative/Myelodysplastic diseases, myelodysplastic syndromes, hodgkin’s lymphoma, histiocytoses.
284p
oursky07
24-10-2023
7
4
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Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by a reciprocal translocation between the long arms of chromosomes 9 and 22 that results in expression of the oncoprotein BCR-ABL1.
6p
viintuit
26-09-2023
4
0
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Chronic myeloid leukemia (CML) is a chronic myeloproliferative neoplasm characterized by excess granulocytes at different stages of maturation and the presence of BCR-ABL1 fusion gene or Philadelphia chromosome. Absolute eosinophilia, basophilia, and monocytosis are not uncommon in CML.
5p
viintuit
26-09-2023
1
0
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Part 1 book "The genetic basis of haematological cancers" includes content: The myelodysplastic syndromes, molecular genetics of the myeloproliferative neoplasms, acute myeloid leukaemia.
218p
oursky01
24-07-2023
2
2
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Extramedullary acute myeloid leukemia (EML), also known as myeloid sarcoma (MS), is an extramedullary solid mass derived from the proliferation of myeloblasts outside of the bone marrow. EML can present independently or concurrently with intramedullary acute myeloid leukemia (iAML).
8p
viwhitewolf
03-07-2023
4
2
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Myeloproliferative neoplasms are a group of diseases with diverse biological and clinical characteristics. As a provisional separate entity, myeloid/lymphoid neoplasms with eosinophilia and genetic rearrangement have been described, which may present an initial clinical behavior of myeloproliferation and be characterized by varied genetic rearrangements.
5p
videadpool
05-05-2023
3
2
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Myeloproliferative neoplasms (MPNs) are a group of haematological malignancies that can be characterised by a somatic mutation (JAK2V617F). This mutation causes the bone marrow to produce excessive blood cells and is found in polycythaemia vera (~95%), essential thrombocythaemia and primary myelofibrosis (both ~50%).
12p
vinarcissa
21-03-2023
2
1
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Myeloproliferative neoplasm is a group of blood cancers, including three main diseases: Essential thrombocythemia, primary myelofibrosis, and polycythemia vera. Several molecular signaling pathways such as JAK/STAT, PI3K or SHP have been demonstrated that play a crucial role in controlling the signaling-mediated immune response related to Myeloproliferative neoplasms.
6p
vimelindagates
18-07-2022
4
2
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In particular, the IL28B gene polymorphisms have been studied and shown to have impacts on drug responses in the treatment of many diseases, such as chronic hepatitis C, chronic hepatitis B, and myeloproliferative neoplasms.
14p
meyerowitz
25-12-2021
13
0
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Patients with Philadelphia-negative Myeloproliferative Neoplasms (MPN) suffer from numerous symptoms and decreased quality of life. Smoking is associated with an increased symptom burden in several malignancies. The aim of this study was to analyze the association between smoking and MPN-related symptom burden and explore MPN patients’ opinions on smoking.
13p
vimahuateng
26-11-2021
15
2
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Although myelodysplastic syndrome (MDS), acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN) – including chronic myeloid leukemia (CML) – and myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are largely clinically distinct myeloid malignancies, epidemiological studies rarely examine them separately and often combine them with lymphoid malignancies, limiting possible etiological interpretations for specific myeloid malignancies.
22p
vianrose2711
27-04-2021
11
1
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The JAK2 V617F mutation is the most frequent somatic change in myeloproliferative neoplasms, making it an important tumour-specific marker for diagnostic purposes and for the detection of minimal residual disease.
13p
vijennie2711
29-09-2020
14
1
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The Philadelphia chromosome−negative myeloproliferative neoplasms (MPN) myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) negatively affect patient quality of life (QoL) and are associated with increased risk of mortality.
10p
vinaypyidaw2711
26-08-2020
8
1
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Patients with the myeloproliferative neoplasms (MPNs) myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) are at increased risk for thrombotic and cardiovascular events and experience a variety of burdensome symptoms.
9p
vibaku2711
22-07-2020
13
1
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Polycythemia vera (PV) is a myeloproliferative neoplasm associated with increased thrombotic and cardiovascular risk, which are key contributors to patient morbidity and mortality.
7p
vibaku2711
22-07-2020
7
1
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Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) with less than 40 cases of patients being reported or clinically suspected meeting with 2008 World Health Organization (“WHO”) diagnostic criteria.
6p
vibaku2711
22-07-2020
9
1
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