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Narrow therapeutic index
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Warfarin is the most widely used oral anticoagulant worldwide, but it has a narrow therapeutic index which necessitates constant monitoring of anticoagulation response. Previous genome-wide studies have focused on identifying factors explaining variance in stable dose, but have not explored the initial patient response to warfarin, and a wider range of clinical and biochemical factors affecting both initial and stable dosing with warfarin.
12p
vioraclene
31-03-2024
9
2
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Carboplatin is the backbone cytotoxic agent for many chemotherapy regimens for lung cancer. Dosing of carboplatin is complicated due to its relationship to renal function and narrow therapeutic index. Overestimation of renal function may lead to supratherapeutic dosing and toxicity, while underestimation may lead to underdosing and therapeutic failure.
15p
vileonardodavinci
23-12-2023
7
3
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Calcium channel blockers (CCBs) are widely used drugs that have a narrow therapeutic index. Even minor overdoses must be treated in-hospital due to the risk of severe hypotension and bradycardia.
8p
vimax2711
30-03-2020
27
1
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Phenytoin, mainly metabolized by cytochrome P450 enzyme system, has a narrow therapeutic index and may have adverse effects due to inter-individual variation in the dose requirement and genetic polymorphisms.
7p
vichengna2711
25-02-2020
15
0
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Nomenclature: The terms active agent and pharmacon designate substances that are capable of modifying life processes irrespective of whether the effects elicited may benefit or harm the organisms concerned. By this definition, a toxin is also a pharmacon. Taken in a narrower sense, a pharmacon means a substance that is used for therapeutic purposes. An unequivocal term for such a substance is medicinal drug.
55p
bigbaby87
04-09-2010
97
8
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