Natural product discovery

Building on the success of the previous editions, the Textbook of drug design and discovery, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects.

451p vimeyers 29-05-2024 3 2   Download

Ebook "Handbook of anticancer drugs from marine origin" also places into context the demand for anticancer nutraceuticals and their use as potential anti-cancer pharmaceuticals and medicines. This study of advanced and future types of natural compounds from marine sources is written to facilitate the understanding of Biotechnology and its application to marine natural product drug discovery research.

801p tudohanhtau1006 29-03-2024 3 1   Download

Ebook "Applied cross-coupling reactions" provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed.

247p coduathanh1122 27-03-2024 1 1   Download

Ebook "Drug discovery in Africa: Impacts of genomics, natural products, traditional medicines, insights into medicinal chemistry, and technology platforms in pursuit of new drugs" has the potential to provide significantly improved treatment of endemic diseases such as malaria, tuberculosis and HIV/AIDS. This book critically reviews the current status of drug discovery research and development in Africa, for diseases that are a major threat to the health of people living in Africa.

453p coduathanh1122 27-03-2024 1 1   Download

Ebook "NMR-bioassay guided isolation of the natural 20S proteasome inhibitors from photorhabdus luminescens: A novel NMR-tool for natural product detection" describes a novel methodology for natural product discovery. Due to its high degree of reproducibility, robustness and sensitivity, the technique can be utilized to detect even trace amounts of bioactive substances in heterogeneous matrices such as fermentation broths or crude organic extracts.

84p nhanphanguyet 28-01-2024 2 2   Download

Part 1 book "Comprehensive analysis of parasite biology" includes content: Discovery of the mechanism of action of novel compounds that target unicellular eukaryotic parasites; antiparasitics from algae; contribution of natural products to drug discovery in tropical diseases; isoxazolines - a novel chemotype highly effective on ectoparasites; trypanosomal cysteine peptidases... and other contents.

320p muasambanhan03 02-01-2024 7 2   Download

Part 1 of ebook "Metabolomics tools for natural product discovery: Methods and protocols" presents the following content: bryophytes - liverworts, mosses, and hornworts - extraction and isolation procedures; plant tissue extraction for metabolomics; detection of polar metabolites through the use of gas chromatography–mass spectrometry; metabolite analysis of biological fluids and tissues by proton nuclear magnetic resonance spectroscopy;...

155p dieptieuung 14-07-2023 4 1   Download

Continued part 1, part 2 of ebook "Metabolomics tools for natural product discovery: Methods and protocols" presents the following content: determination of absolute configuration using single crystal X-Ray diffraction; natural product chemistry in action: the synthesis of melatonin metabolites K1 and K2; discovery, biosynthesis, and rational engineering of novel enterocin and wailupemycin polyketide analogues; bioassays for anticancer activities; screening for antidiabetic activities; screening for antibacterial, antifungal, and anti quorum sensing activity;...

158p dieptieuung 14-07-2023 3 1   Download

In the context of sources for natural products discovery are going scarcer, exploiting biotechnologically potential compounds from marine microbial symbionts is considered a relatively new trend. In our study a total of fifteen fungal strains were isolated from marine algal samples belonging to species Kappaphycus cottonii, K. striatus, Gracilaria eucheumatoides and Betaphycus gelatinus collected in Nha Trang in 2017.

7p vicaptainmarvel 21-04-2023 5 3   Download

This history of antimicrobials is marked with impressive discoveries, the majority of which have their origin in natural products. However in this work, the antimicrobial activity of β- nitrostyrenes and related compounds of synthetic origin is reviewed and investigated with a particular focus on the influence of fluorine functionality. Various fluorinated β-methyl-β-nitrostyrene compounds were prepared, their minimum inhibition concentration in cultures of Gram positive, Gram negative and a fungus and their lipophilicity was determined.

133p runthenight05 01-03-2023 2 2   Download

Natural products are currently underrepresented in the small-molecules drug library largely because of their extremely low yields, lower supply of natural resources and complex structures posing greater difficulty for structural modification and practical synthesis. Despite the challenges natural product based drugs continue to make impact in drug discovery.

223p spiritedaway36 26-11-2021 10 2   Download

The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated as a potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.

11p vibeauty 23-10-2021 13 0   Download

Among naturally occurring small molecules, tRNA-derived cyclodipeptides are a class that have attracted attention for their diverse and desirable biological activities. However, no tools are available to link cyclodipeptide synthases identified within prokaryotic genome sequences to their chemical products. Consequently, it is unclear how many genetically encoded cyclodipeptides represent novel products, and which producing organisms should be targeted for discovery.

11p vibeauty 23-10-2021 6 0   Download

Bacteria within the genus Streptomyces remain a major source of new natural product discovery and as soil inoculants in agriculture where they promote plant growth and protect from disease. Recently, Streptomyces spp. have been implicated as important members of naturally disease-suppressive soils.

13p viansan2711 30-07-2021 11 1   Download

Verifying the proteins that are targeted by compounds of natural herbs will be helpful to select natural herb-based drug candidates. However, this entails a great deal of effort to clarify the interaction throughout in vitro or in vivo experiments.

9p vioklahoma2711 19-11-2020 7 1   Download

Growing concern about the emergence of antibiotic resistance is compelling the pharmaceutical industry to search for new antimicrobial agents. The availability of genome sequences has enabled the development of computational mining as an important tool in the discovery of natural products with antibiotic effect

10p vicoachella2711 27-10-2020 13 0   Download

Prostate cancer is the most commonly diagnosed malignancy among men. The Discovery of new agents for the treatment of prostate cancer is urgently needed. Compound WZ35, a novel analog of the natural product curcumin, exhibited good anti-prostate cancer activity, with an IC50 of 2.2 μM in PC-3 cells.

11p vimoscow2711 29-08-2020 4 0   Download

The isolation of natural products from marine fish includes several essential steps. The process begins with the isolation of tissues from the fish. Often, in the past, the isolation of compound has been a random process. However there is now a growing recognition that the source of fish samples can be important for increasing the success rate of bioactive discovery.

9p kethamoi6 29-06-2020 19 1   Download

Medicinal plants are the gift of nature to mankind. Since the dawn of human civilization, medicinal plants are being used for treating different ailments of human being in traditional and recognized system of health care. Though medicinal plants secured an important position for their therapeutic, fragrance and flavoring qualities for generations, but the discovery of synthetic drugs overshadowed it for a while. Due to increase in awareness about health and hygiene, people are found to be more inclined towards herbal products especially those derived from plants.

8p trinhthamhodang1213 27-05-2020 12 1   Download

Fontainea picrosperma, a subcanopy tree endemic to the rainforests of northeastern Australia, is of medicinal significance following the discovery of the novel anti-cancer natural product, EBC-46.

12p vihashirama2711 21-05-2020 7 1   Download