Neck squamous cells carcinomas
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Cervical cancer is the fourth most common cancer in women, with an estimated 342,000 deaths worldwide in 2020. Current standard of care in the UK for locally advanced cervical cancer is concurrent chemoradiotherapy with weekly cisplatin, yet 5-year overall survival rates are only 65% with a distant relapse rate of 50%.
10p vishanshan 27-06-2024 1 1 Download
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Head and neck squamous cell carcinoma (HNSCC) represents a common and heterogeneous malignancy of the oral cavity, pharynx and larynx. Surgery and radio(chemo)therapy are the standard treatment options and also have great influence on the composition of the tumor microenvironment and immune cell functions.
13p vishanshan 27-06-2024 1 1 Download
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Altered glycosylation is a hallmark of cancer associated with therapy resistance and tumor behavior. In this study, we investigated the glycosylation profile of stemness-related proteins OCT4, CIP2A, MET, and LIMA1 in HNSCC tumors.
11p vishanshan 27-06-2024 3 1 Download
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The study aimed to assess the impact of parotid lymph nodes (LNs) on the prognosis of patients with cutaneous squamous cell carcinomas of the head and neck (HNcSCC), and to develop an alternative LN assessment method to enhance locoregional control (LRC) and overall survival (OS) stratification.
10p vishanshan 27-06-2024 1 1 Download
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This study aimed to develop and validate a machine learning (ML)-based fusion model to preoperatively predict Ki-67 expression levels in patients with head and neck squamous cell carcinoma (HNSCC) using multiparametric magnetic resonance imaging (MRI).
14p vikoch 27-06-2024 3 1 Download
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The current study aimed to evaluate the impact of four different single nucleotide polymorphisms (SNPs), E2F1 (rs3213183 and rs3213180) and E2F2 (rs2075993 and rs3820028), on LSCC development, morphological features, and patient 5-year survival rate.
9p vikoch 27-06-2024 3 1 Download
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Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy characterized by tumor heterogeneity, locoregional metastases, and resistance to existing treatments. Although a number of genomic and molecular alterations associated with HNSCC have been identified, they have had limited impact on the clinical management of this disease.
18p vibransone 28-03-2024 9 2 Download
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It is frequently assumed that pre-invasive lesions are simpler precursors of cancer and will contain a limited subset of the genomic changes seen in their associated invasive disease. Driver mutations are thought to occur early, but it is not known how many of these are present in pre-invasive lesions.
14p vioraclene 31-03-2024 6 2 Download
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Head and neck squamous cell carcinomas (HNSCCs) represent a heterogeneous group of cancers for which human papilloma virus (HPV) infection is an emerging risk factor. Previous studies showed promoter hypermethylation in HPV(+) oropharyngeal cancers, but only few consistent target genes have been so far described, and the evidence of a functional impact on gene expression is still limited.
12p vioraclene 31-03-2024 3 1 Download
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This study aims to identify microbiomic differences in paired tumor and non-tumor tissue samples in a large group of 121 patients with head and neck squamous cell carcinomas and correlate these differences with clinical-pathologic features.
10p vioraclene 31-03-2024 5 2 Download
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Ebook "Impact of genetic targets on cancer therapy" provides a forum for original peer-reviewed short communications, full-length research and review articles on new research findings and developments on the topic of genetic targets on cancer therapies. As the field is highly important it requires co-operation between research communities from all over the world to share their knowledge and experience in order to move the field forward.
447p cotieubac1004 15-03-2024 2 0 Download
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Lower lip squamous cell carcinoma is a significant subtype of head and neck cancer, constituting about 25–30% of cases. Traditional surgical methods, like primary closure, have limitations in managing large resections of lip tumors.
6p vitiki 30-01-2024 5 2 Download
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Patients with large cutaneous squamous cell carcinoma of the scalp are a treatment challenge. We report a case of dramatic radiotherapy response of a patient with a giant cutaneous squamous cell carcinoma of the scalp with extensive skull destruction and suspected infiltration of the dura mater and superior sagittal sinus
6p vilazada 31-01-2024 4 2 Download
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Immune checkpoint inhibitors might cause immune-related adverse events that are still largely unknown. The study presents the first reported case of type 1 diabetes in a patient with head and neck squamous cell carcinoma treated with pembrolizumab monotherapy, in Japan.
6p vitiki 30-01-2024 5 2 Download
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The optimal duration of anti-PD-1 for cancer therapy has not been tested, especially when using combination therapy. Epidermal growth factor receptor (EGFR) pathway blocker was the top compound that enhanced T-cell killing of tumor cells in a high-throughput immune-oncology screen, possibly by stimulate the antigen presentation machinery and other mechanisms.
9p vileonardodavinci 23-12-2023 2 2 Download
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Recurrent/ metastatic squamous cell carcinoma of head and neck (R/M SCCNH) is still a difficult-totreat disease with poor clinical outcomes and limited treatment choices. In view of locoregional recurrent versus dis‑ tant metastatic SCCHN, the therapeutic efcacy of cetuximab-containing regimen and relevant prognostic factors for these two groups may be different.
10p vileonardodavinci 23-12-2023 4 2 Download
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New concepts for a more efective anti-cancer therapy are urgently needed. Experimental faws rep‑ resent a major counter player of this development and lead to inaccurate and unreproducible data as well as unsuc‑ cessful translation of research approaches into clinics. In a previous study we have created epithelial cell cultures from head and neck squamous cell carcinoma (HNSCC) tissue.
13p vileonardodavinci 23-12-2023 2 2 Download
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Tumor microenvironment (TME) is of great importance to regulate the initiation and advance of cancer. The immune infiltration patterns of TME have been considered to impact the prognosis and immunotherapy sensitivity in Head and Neck squamous cell carcinoma (HNSCC). Whereas, specific molecular targets and cell components involved in the HNSCC tumor microenvironment remain a twilight zone.
18p vileonardodavinci 23-12-2023 5 2 Download
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Postoperative chemoradiotherapy (CRT) is a standard therapy for patients with high-risk factors for head and neck squamous cell carcinoma, including positive margin and extra-nodal extension (ENE). However, the prognostic impact of the number of pathological metastatic lymph nodes (pLNs) in hypopharyngeal carcinoma (HPC) is unclear.
6p vileonardodavinci 23-12-2023 4 3 Download
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Various cancer stem cell (CSC) biomarkers and the genes encoding them in head and neck squamous cell carcinoma (HNSCC) have been identified and evaluated. However, the validity of these factors in the prognosis of HNSCC has been questioned and remains unclear.
13p vileonardodavinci 23-12-2023 7 3 Download