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Negative alphas
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Although radical surgical resection is the most effective treatment for hepatocellular carcinoma (HCC), the high rate of postoperative recurrence remains a major challenge, especially in patients with alpha-fetoprotein (AFP)-negative HCC who lack effective biomarkers for postoperative recurrence surveillance. In this study, we propose to develop a radiomics model based on preoperative CECT to predict the risk of early recurrence after surgery in AFP-negative HCC.
12p
vikoch
27-06-2024
1
1
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Approximately 40% of hormone receptor positive/human epidermal receptor 2 negative (HR+/HER2-) metastatic breast cancer (mBC) patients harbor phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) mutations. However, associations between PIK3CA mutation status and clinical outcomes among patients with HR+/HER2- mBC have been heterogeneous across clinical trials.
11p
vialfrednobel
23-12-2023
5
3
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Aerococcus urinae is a bacterium of emerging clinical interest that most commonly causes urinary tract infections (UTI) but can also result in invasive infections. It is a catalase-negative, alpha-haemolytic gram-positive coccus that grows in clusters or tetrads and usually causes urinary tract infections.
5p
videadpool
05-05-2023
3
2
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The adsorption behavior of the model proteins: alpha-Lactalbumin, Bovine Serum Albumin, Lysozyme, and a monoclonal antibody, in single component and in binary mixtures, was investigated on two different hydrophobic interaction chromatography resins using both static and dynamic methods.
12p
viginny
23-12-2022
10
3
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Lecture Computer graphics - Lesson 24: Lightning II. The main topics covered in this chapter include: clamping color values, scaling color values by intensity, negative colors and dark lights, the blending operation, the alpha blending equation, the alpha blending formula, the frame buffer,...
51p
youzhangjing_1909
28-04-2022
9
5
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Lecture Class #15: Accounting trading strategies. After studying this section will help you understand: A high stock return (relative to other stocks) does not immediately imply you are getting a “free lunch” or an arbitrage opportunity exists.
15p
huangminghao_1902
27-02-2022
15
1
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As a co-receptor for fibroblast growth factor 23, klotho plays a pivotal role in phosphate metabolism. The kidney is known to be the main source of soluble alpha-klotho and the principal regulator of its concentration.
9p
vidarwin
22-02-2022
8
1
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We investigated the effect of endoplasmic reticulum (ER) protein 29 (ERp29) on thyroglobulin (Tg) secretion and its negative regulation by microRNAs (miRNAs). ERp29 overexpression promoted Tg secretion from thyrocytes of PCCL3 cells via activation of ER stress sensors, including activation of transcription factor 6 fragmentation, XBP1 mRNA splicing by inositol-requiring enzyme 1, and phosphorylation of eukaryotic initiation factor 2 alpha as downstream actions of RNA-dependent protein kinase-like ER kinase.
6p
dolomite36
30-12-2021
10
0
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The objective of this study is to propose some solutions to improve visitors’ satisfaction to Phu Quoc Island. The data of the study were collected from domestic and foreign tourists to the island. In the research, descriptive statistical methods, Cronbach Alpha reliability coefficient, factor analysis and regression analysis are used. The results show the positive points to be promoted and the negative points to be overcome then the researchers propose solutions to improve the satisfaction levels of visitors when experiencing tourist services in Phu Quoc in the future.
7p
huyetthienthan
23-11-2021
20
5
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Alpha-fetoprotein-negative hepatocellular carcinoma (AFP-NHCC) (< 8.78 ng/mL) have special clinicopathologic characteristics and prognosis. The aim of this study was to apply a new method to establish and validate a new model for predicting the prognosis of patients with AFP-NHCC.
16p
vianrose2711
27-04-2021
6
1
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Protective ventilation with lower tidal volume (VT) and higher positive end-expiratory pressure (PEEP) reduces the negative additive effects of mechanical ventilation during systemic inflammatory response syndrome.
10p
vimontana2711
05-04-2021
12
2
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Fenofibrate induces apoptosis of triple-negative breast cancer cells via activation of NF-κB pathway
There are a lot of unmet needs in patients with triple-negative breast cancer (TNBC). Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, has been used for decades to treat hypertriglyceridaemia and mixed dyslipidaemia.
13p
virose2711
25-09-2020
14
0
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The role and clinical value of ERβ1 expression is controversial and recent data demonstrates that many ERβ antibodies are insensitive and/or non-specific. Therefore, we sought to comprehensively characterize ERβ1 expression across all sub-types of breast cancer using a validated antibody and determine the roles of this receptor in mediating response to multiple forms of endocrine therapy both in the presence and absence of ERα expression.
16p
vilisa271
22-09-2020
22
0
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Estrogen receptor alpha (ERa/ESR1) expression is regulated by alternative splicing. Its most frequently detectable exon7 skipping isoform (ERaD7) is a dominant negative variant. Elevated expression of ERaD7 was already detected in endometrial cancer (EC), while its potential prognostic significance has not been characterized so far.
11p
vialabama2711
21-09-2020
18
0
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The peroxisome proliferator-activated receptor alpha (PPARα) controls lipid/energy homeostasis and inflammatory responses. The truncated splice variant PPARα-tr was suggested to exert a dominant negative function despite being unable to bind consensus PPARα DNA response elements.
15p
viamsterdam
18-09-2020
14
1
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Triple-negative breast cancer (TNBC) is an aggressive histological subtype with limited treatment options and very poor prognosis following progression after standard chemotherapeutic regimens.
11p
vimale2711
25-08-2020
10
1
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This present study was aimed to identify the skin sensitization potential of the etanercept, in guinea pigs by following Guinea Pig Maximization Test (GPMT) of Magnusson and Kligman method. The animals were divided into two groups; negative control comprising six males and 6 females and treatment groups having ten males and ten females.
10p
nguaconbaynhay7
15-08-2020
7
1
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Previously, we have shown that miR-18a and miR-18b gene expression strongly correlates with high proliferation, oestrogen receptor -negativity (ER− ), cytokeratin 5/6 positivity and basal-like features of breast cancer.
14p
viorochimaru2711
01-06-2020
3
0
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Alpha-methylacyl-CoA racemase (AMACR) is a key enzyme responsible for the metabolism of branched-chain fatty acids. It has been found to be an important prognostic factor in numerous types of cancers.
7p
vinasaki2711
12-11-2019
11
0
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Patients affected by liver cirrhosis are at high risk for developing hepatocellular carcinoma. The aim of this study was to evaluate the feasibility of PIVKA-II (protein induced by vitamin K absence or antagonist-II) alone or in combination with α-1 fetoprotein, as a screening marker for development of hepatocellular carcinoma. Subjects and methods: A case-control study was conducted on 103 Military Hospital. 53 patients affected by hepatocellular carcinoma were considered as cases, while 31 patients affected by liver cirrhosis were considered as control.
7p
caygaolon
01-11-2019
21
0
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