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Negative selection
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Programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) are the two most common immune checkpoints targeted in triple-negative breast cancer (BC). Refining patient selection for immunotherapy is non-trivial and finding an appropriate digital pathology framework for spatial analysis of theranostic biomarkers for PD-1/PD-L1 inhibitors remains an unmet clinical need.
11p
vishanshan
27-06-2024
1
1
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The study assesses the impact of foreign direct investment (FDI) and institutional quality on the environment, while also determining the role of institutional quality in the environmental effects of FDI in developing Asian countries. By analyzing panel data from 10 developing Asian economies for the period 1996-2021 using the System Generalized Method of Moments, the research finds evidence confirming the negative impact of FDI on environmental quality in these countries.
13p
leminhvu111
07-06-2024
3
0
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This article presented the analysis and description of language transfer in English writing products of 80 first year students at Vietnam Forestry University. Language transfer is described in terms of lexis, syntax, and discourse which are selected from 3 types of writing: letter, description and narrative.
10p
vioraclene
01-04-2024
2
0
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Ebook "Nanoscale technology for advanced lithium batteries" surveys the new materials and approaches needed to use nanotechnology to introduce the next generation of advanced lithium batteries, currently the most promising energy storage devices available. It provides an overview of nanotechnology for lithium batteries from basic to applied research in selected high technology areas. The book especially focuses on near-term and future advances in these fields.
275p
nhanphanguyet
28-01-2024
4
2
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Continued part 1, part 2 of ebook "Equity valuation and negative earnings: The case of the dot.com bubble" provides readers with contents including: empirical study; period, sample selection and definition of variables; analysis and discussion of results; conclusions and suggestions for further research; criteria for subdivision of samples; methodology of fama and macbeth; research hypotheses; validation of empirical research hypotheses;...
81p
mocthanhdao0210
19-11-2023
5
4
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Multitask learning (MTL) using electronic health records allows concurrent prediction of multiple endpoints. MTL has shown promise in improving model performance and training efficiency; however, it often suffers from negative transfer – impaired learning if tasks are not appropriately selected.
11p
vighostrider
25-05-2023
4
2
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Climate change is expected to have a negative impact on food availability. While most efforts have been directed to reducing greenhouse gas emissions, complementary strategies are necessary to control the detrimental effects of climate change on farm animal performance.
10p
vihagrid
30-01-2023
5
3
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To satisfy an increasing demand for dietary protein, the poultry industry has employed genetic selection to increase the growth rate of broilers by over 400% in the past 50 years. Although modern broilers reach a marketable weight of ~ 2 kg in a short span of 35 days, a speed twice as fast as a broiler 50 years ago, the expedited growth has been associated with several negative detrimental consequences.
14p
vihagrid
30-01-2023
10
3
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Photobacteriosis is an infectious disease developed by a Gram-negative bacterium Photobacterium damselae subsp. piscicida (Phdp), which may cause high mortalities (90–100%) in sea bream. Selection and breeding for resistance against infectious diseases is a highly valuable tool to help prevent or diminish disease outbreaks, and currently available advanced selection methods with the application of genomic information could improve the response to selection.
14p
vihagrid
30-01-2023
7
3
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An Electrokinetic Chromatography method was developed for the stereoselective analysis of sulfoxaflor, a novel sulfoximine agrochemical with two chiral centers. A screening with fourteen negatively charged CDs was performed and Succinyl-β-CD (Succ-β-CD) was selected.
9p
viginny
23-12-2022
9
3
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As opposed to observation of the neck, elective neck dissection has a survival benefit for cN0 oropharyngeal squamous cell carcinoma (OPSCC). However, there are limited date on level IV neck dissection in human papillomavirus (HPV)-negative OPSCC because most earlier studies did not stratify by P16 or HPV status.
10p
vikolindagrabar
27-07-2022
6
2
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Chagas disease is increasingly recognized in the southern U.S., where triatomine vectors transmit Trypanosoma cruzi among wildlife and domestic dogs with occasional vector spillover to humans. As in humans, clinical outcome in dogs is variable, ranging from acute death to asymptomatic infections or chronic heart disease.
12p
vigalileogalilei
28-02-2022
9
1
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An important goal of cancer genomics is to identify systematically cancer-causing mutations. A common approach is to identify sites with high ratios of non-synonymous to synonymous mutations; however, if synonymous mutations are under purifying selection, this methodology leads to identification of false-positive mutations.
12p
vialfrednobel
29-01-2022
7
0
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Nullomers and nullpeptides are short DNA or amino acid sequences that are absent from a genome or proteome, respectively. One potential cause for their absence could be their having a detrimental impact on an organism.
24p
viarchimedes
26-01-2022
7
0
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The study aims to explore factors that affect the choice of M & A payment methods (cash, stock swap or mixed payment) conducted by financial institutions in Vietnam. Methodology: To carry out the analysis, this study focuses the past literature relating to payment methods in M&As and summarizes the positive and negative effects of different payment methods.
7p
vihassoplattner
07-01-2022
14
2
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Maintaining landscape connectivity through identifying movement corridors is the most recommended conservation strategy to reduce the negative impacts of habitat loss and isolation. The basis of most connectivity modelling approaches for modelling corridors is that species choose movement pathways based on the same criteria they used to choose habitats. However, species behave differently in using landscape elements for moving than for selecting habitat. In other words, suitability of a given landscape feature may differ between moving and habitat use stages.
12p
dolomite36
30-12-2021
14
0
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This review provides new insight into the RFI and its relationship with productive traits in different species of poultry. In poultry breeding programs, use of the RFI in selection procedures as a negative trait must be adopted to produce an efficient breed with low feed costs and high productivity. From the point of view of an environmental perspective, selecting birds with lower RFI reduces emissions of ammonia and greenhouse gases from poultry houses.
5p
schindler
30-12-2021
14
0
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This study determines correlation of biofilm-forming bacteria for selected metals, antibiotics and dyes. Total 12 strains having biofilm production potential were targeted in this study. Majority of them were Gram negative excluding MB377 and MB378, and facultative anaerobes. Isolates were mesophilic and exhibited growth capacity over a wide variety of pHs.
9p
mudbound
10-12-2021
11
1
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The aminated-silica nanoparticles with a positive zeta potential interact with GFP having a negative zeta potential via ionic force. GFP immobilized by the aminated silica nanoparticles greatly enhances (ca. 2 times) the bioluminescence intensity compared to free GFP. The lipase/aminated-silica nanoparticles catalyzed the transesterification reaction of 1-hexanol and ethyl acetate.
7p
spiritedaway36
28-11-2021
6
0
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The online shopping cannot be considered as an emerging trend because it has become a standard way of doing business. The focus of online retailers’ interest should be aimed at the customer behavior during purchasing process. The aim of this paper is to describe and analyze the use of Internet in the pre-purchase stage of customers in selected countries. We found that there is a significant negative correlation between development indicators of nations and the use of Internet in pre-purchase stage of shopping.
6p
huyetthienthan
23-11-2021
18
4
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