Neighborhood cells

Spatial multi-omic studies have emerged as a promising approach to comprehensively analyze cells in tissues, enabling the joint analysis of multiple data modalities like transcriptome, epigenome, proteome, and metabolome in parallel or even the same tissue section. This review focuses on the recent advancements in spatial multi-omics technologies, including novel data modalities and computational approaches.

17p vicwell 29-02-2024 5 2   Download

We develop a method, VIPER, to impute the zero values in single-cell RNA sequencing studies to facilitate accurate transcriptome quantification at the single-cell level. VIPER is based on nonnegative sparse regression models and is capable of progressively inferring a sparse set of local neighborhood cells that are most predictive of the expression levels of the cell of interest for imputation.

15p vigalileogalilei 27-02-2022 32 1   Download

Advances in fluorescence labeling and imaging have made it possible to acquire in vivo records of complex biological processes. Analysis has lagged behind acquisition in part because of the difficulty and computational expense of accurate cell tracking.

8p vikentucky2711 26-11-2020 8 0   Download

Congregations Manage Volunteers in Social Outreach. We learned that an estimated 83 percent of the nation’s 380,000 congregations have some kind of social service, community development, or neighborhood organizing project. Although most congregations have social service outreach programs, most are involved as partners or sponsors and therefore do not manage volunteers themselves. However, one in three congregations— an estimated 129,000 such organizations—have responsibility for managing volunteers in social service outreach activities.

50p dacotaikhoan 26-04-2013 29 1   Download

Neighborhoods may influence late-life health through a number of pathways (see Figure 1). The IOM (1991) disablement framework, which distinguishes among disease, functional limitation, and disability, serves as the starting point for this framework. We extend the IOM framework to include mortality and self-rated general health status, which are both influenced by disease, functional limitation, and disability, as well as the variety of individual and neighborhood factors that influence health in general.

19p taisaokhongthedung 01-01-2013 48 6   Download

Fluorescein angiography is a remarkable in vivo technique, because it is able to resolve the minute capillaries in the neighborhood of the foveal avascular zone which measure only 3.5 μm in diameter (top). This is half the diameter of red blood cells. Because of their small diameter, the capillaries in the vicinity of the foveal avascular zone cannot be perfused with whole blood, since the red blood cells have to change their shape in order to pass, thus requiring much more space (bottom).

132p gian_anh 18-10-2012 37 3   Download

“Epigenetics” as introduced by ConradWaddington in 1946, is defined as a set of interactions between genes and the surrounding environment, which determines the phenotype or physical traits in an organism, (Murrell et al., 2005;Waddington, 1942). Initial research focused on genomic regions such as heterochromatin and euchromatin based on dense and relatively loose DNA packing, since these were known to contain inactive and active genes respectively, (Yasuhara et al., 2005).

218p yeutinh98 22-09-2012 59 11   Download