Neuroblastoma

Neuroblastoma is a common extracranial solid tumor of childhood. Recently, multiple treatments have been practiced including Iodine-131-metaiodobenzylguanidine radiation (131I-MIBG) therapy. However, the outcomes of efficacy and safety vary greatly among different studies.

10p vikolindagrabar 27-07-2022 1 1   Download

The bone marrow (BM) is the most common site of dissemination in patients with aggressive, meta-static neuroblastoma (NB). However, the molecular mechanisms underlying the aggressive behavior of NB cells in the BM niche are still greatly unknown. In the present study, we explored biological mechanisms that play a critical role in NB cell survival and progression in the BM and investigated potential therapeutic targets.

17p visusanwojcicki 28-06-2022 4 1   Download

Although isolated central nervous system (CNS) relapses are rare, they may become a serious clinical problem in intensively treated patients with high-risk neuroblastoma (NBL). The aim of this study is the presentation and assessment of the incidence and clinical course of isolated CNS relapses.

9p visusanwojcicki 28-06-2022 4 2   Download

Temozolomide (TMZ) induces a G2/M cell cycle arrest and is used for treatment of paediatric tumours, especially neuroblastomas. Patients treated with TMZ frequently receive midazolam for sedation prior to surgery and other interventions. Previous studies suggested both cytoprotective and apoptosis-inducing properties of midazolam. Therefore, the impact of midazolam on TMZ-induced cytotoxicity was investigated in vitro.

8p viisaacnewton 25-04-2022 4 2   Download

Wild boar-derived hepatitis E (HEV) genotype 3 virus has been successfully isolated in cell lines of human origin only. Considering the zoonotic potential and possible extrahepatic localisation of genotype 3 strain, it is important to investigate the viability of cell lines of different animal and tissue origins.

11p vigalileogalilei 28-02-2022 4 0   Download

Novel methylene-tethered tetrahydroquinolines (THQs) and cyclopenta[b]pyridines were synthesized by onepot multicomponent reactions of Mannich bases, enolizable ketones, and NH4 OAc in water by an environmentally friendly K-10 montmorillonite clay-catalyzed reaction.

18p tudichquannguyet 29-11-2021 2 0   Download

Neuroblastoma (NB) patients with MYCN amplification or overexpression respond poorly to current therapies and exhibit extremely poor clinical outcomes. PI3K-mTOR signaling-driven deregulation of protein synthesis is very common in NB and various other cancers that promote MYCN stabilization.

13p vimahuateng 26-11-2021 1 0   Download

Minichromosome maintenance complex component 6 (MCM6), as an important replication permission factor, is involved in the pathogenesis of various tumors. Here we studied the expression of MCM6 in neuroblastoma and its influence on tumor characteristics and prognosis.

14p vimahuateng 26-11-2021 2 0   Download

Neuroblastoma (NB) is one of the most frequently diagnosed tumors in infants. NB is a neuroendocrine tumor type with various characteristics and features, and with diverse outcome. The most malignant NBs have a 5-year survival rate of only 40–50%, indicating the need for novel and improved treatment options.

14p vimahuateng 26-11-2021 1 0   Download

Luận văn được thực hiện với mục tiêu: mô tả một số đặc điểm lâm sàng và cận lâm sàng của bệnh nhi mắc u neuroblastoma tuyến thượng thận tại Bệnh viện Nhi Trung ương từ tháng 1 năm 2015 đến tháng 6 năm 2019. Đánh giá kết quả phẫu thuật nội soi điều trị u neuroblastoma tuyến thượng thận ở trẻ em tại Bệnh viện Nhi Trung ương từ tháng 1 năm 2015 đến tháng 6 năm 2019. Mời các bạn cùng tham khảo.

101p xiaojingteng 24-06-2021 18 2   Download

Majority of neuroblastoma patients develop metastatic disease at diagnosis and their prognosis is poor with current therapeutic approach. Major challenges are how to tackle the mechanisms responsible for tumorigenesis and metastasis.

12p vianrose2711 27-04-2021 6 3   Download

The growth- and plasticity-associated protein-43 (GAP43) is biasedly expressed in indigestive system and nervous system. Recent study has shown that GAP43 is responsible for the development of neuronal growth and axonal regeneration in normal nervous tissue, while serves as a specific biomarker of relapsed or refractory neuroblastoma.

10p vianrose2711 27-04-2021 7 0   Download

Pulmonary nocardiosis frequently develops as an opportunistic infection in cell-mediated immunosuppressive patients, and sometimes requires differentiation from pulmonary malignancy. Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a neoplastic disorder which leads to impaired cell-mediated immunity, and is commonly associated with small cell lung cancer (SCLC).

6p vimontana2711 05-04-2021 5 0   Download

This is initially report of autologous stem cell transpant for high risk neuroblastoma. Even only two patients, the results showed that stem cell transplant was safe and effective. We are continuing to implement for more case with high risk neuroblastoma and will have better report with a bigger number.

5p trinhthamhodang1218 03-03-2021 10 0   Download

There is increasing evidence of a pivotal role for regulated mRNA translation in control of developmental cell fate transitions. Physiological and pathological stem and progenitor cell self-renewal is maintained by the mRNA-binding protein, Musashi1 through repression of translation of key mRNAs encoding cell cycle inhibitory proteins.

9p viwyoming2711 16-12-2020 5 1   Download

Neuroblastoma Tumor (NT) is one of the most aggressive types of infant cancer. Essential to accurate diagnosis and prognosis is cellular quantitative analysis of the tumor. Counting enormous numbers of cells under an optical microscope is error-prone.

16p vikentucky2711 26-11-2020 17 1   Download

More than fifty percent of neuroblastoma (NB) patients with adverse prognosis do not benefit from treatment making the identification of new potential targets mandatory. Hypoxia is a condition of low oxygen tension, occurring in poorly vascularized tissues, which activates specific genes and contributes to the acquisition of the tumor aggressive phenotype.

11p vioklahoma2711 19-11-2020 6 1   Download

Ultra-conserved regions (UCRs) are segments of the genome (≥ 200 bp) that exhibit 100% DNA sequence conservation between human, mouse and rat. Transcribed UCRs (T-UCRs) have been shown to be differentially expressed in cancers versus normal tissue, indicating a possible role in carcinogenesis.

13p vijennie2711 29-09-2020 12 1   Download

Aggressive neuroblastoma remains a significant cause of childhood cancer death despite current intensive multimodal treatment protocols. The purpose of the present work was to characterize the genetic and clinical diversity of such tumors by high resolution arrayCGH profiling.

14p vijennie2711 29-09-2020 6 0   Download

Neuroblastoma (NB) is the most common extracranial solid tumor in children. NB tumors and derived cell lines are phenotypically heterogeneous. Cell lines are classified by phenotype, each having distinct differentiation and tumorigenic properties.

11p virose2711 24-09-2020 6 0   Download