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Neuroendocrine differentiation
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Pancreatic neuroendocrine neoplasms (PanNENs) fall into two subclasses: the well-differentiated, lowto high-grade pancreatic neuroendocrine tumors (PanNETs), and the poorly-differentiated, high-grade pancreatic neuroendocrine carcinomas (PanNECs). While recent studies suggest an endocrine descent of PanNETs, the origin of PanNECs remains unknown.
14p
viellison
28-03-2024
3
2
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Part 1 book "Reproductive physiology of mammals - From farm to field and beyond" includes content: Introduction; life, reproduction and sex; oreganization and structure of mammalian reproductibe systems; sexual differentiation; functional anatomy of reproductive systems genital organs; functional antomy of reproductive systems - neuroendocrine systems; principles of reprodutive endocirinology; puberty.
193p
muasambanhan07
20-02-2024
3
0
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Primary hepatic neuroendocrine tumours (PHNETs) are a rare form of hepatic neoplasms, and it is difficult to differentiate them from common hepatic malignancies in routine imaging studies.
7p
vitiki
30-01-2024
5
2
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Neuroendocrine differentiation (NED) in colorectal cancer (CRC) cells has been known for decades, and our previous meta-analysis indicated that CRC patients with neuroendocrine differentiation have a lower 5-year survival rate. In recent years, an increasing number of studies have found that exosome-derived long non-coding RNAs (lncRNAs) play important roles in cancer progression and metastasis.
17p
vimichaelfaraday
28-12-2023
11
3
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Although neuroendocrine tumors (NET) are classed as rare, they have a high prevalence and their incidence is increasing. Effective treatment with lutetium 17-[177Lu]Lu-oxodotreotide (Lutathera®) is possible in patients with well-differentiated NET, improving progression-free survival (PFS), overall survival (OS), and quality of life (QoL).
6p
vileonardodavinci
23-12-2023
2
2
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Part 1 book "Hormones and reproduction of vertebrates (Vol 2: Amphibians)" includes content: Sex determination and sexual differentiation in amphibians, neuroendocrine control of reproduction in amphibians, testicular structure and control of sperm development in amphibians, hormones and the female reproductive system of amphibians, hormones, sex accessory structures, and secondary sexual characteristics in amphibians.
117p
muasambanhan01
13-12-2023
8
3
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Small intestinal neuroendocrine tumors (SI-NET) are highly differentiated and genetically stable malignant tumors, yet they often present with advanced metastatic spread at the time of diagnosis. In contrast to many other types of malignant tumors, primary SI-NET are often asymptomatic and typically smaller in size compared to adjacent lymph node metastases.
12p
vischultz
20-10-2023
5
1
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Part 1 book "Hormones and reproduction of vertebrates (Vol 5 - Mammals)" includes content: Sexual differentiation of the mammalian brain, neuroendocrine control of gonadotropins in mammals, endocrine and paracrine regulation of mammalian spermatogenesis, the endocrinology of the mammalian ovary, hormones and pregnancy in eutherian mammals, the comparative physiology of parturition in mammals - hormones and parturition in mammals, stress and reproduction in mammals... and other contents.
198p
oursky05
20-09-2023
2
1
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Although anaplastic lymphoma kinase (ALK) is overexpressed in several primary solid tumor types, its role in endometrial carcinoma (Em Ca) remains unclear. Methods We evaluated expression of ALK and its related molecules in clinical samples consisting of 168 Em Ca tissues. We also used Em Ca cell lines to evaluate the functional role of ALK.
13p
vioracle
29-09-2023
2
2
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Well-differentiated (WD) neuroendocrine tumors (NETs) are a group of rare neoplasms with limited therapeutic options. Cabozantinib is an inhibitor of multiple tyrosine kinases with a pivotal role in NET pathogenesis, including c-MET and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2).
10p
vioracle
29-09-2023
8
2
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Neuroendocrine carcinomas (NECs) of the luminal gastrointestinal tract and pancreas are rare, poorly differentiated neoplasms. There has been difficulty identifying associated risk factors given their very low incidence. Here we present three cases of NEC diagnosed in an 8-month period in a Minneapolis safety-net hospital.
3p
viintuit
26-09-2023
1
0
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Neuroendocrine neoplasms (NENs) represent a diverse group of tumors arising from neuroendocrine cells. Current World Health Organization (WHO) classification is based on tumor differentiation and grade defined by mitotic rate and/or Ki-67 index to determine prognosis and treatment options.
6p
viintuit
26-09-2023
3
0
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Chronic diarrhea is a common chief complaint in the pediatric population with a wide range of diagnostic differentials; as such, whilst suspecting common causes, less prevalent conditions tend to be overlooked, such as neuroendocrine tumor pathologies. VIPomas are characterized by hypersecretion of the vasoactive intestinal peptide (VIP), causing watery diarrhea, hypokalemia, and achlorhydria.
7p
viintuit
26-09-2023
2
0
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Part 1 book "Hormones and reproduction of certebrates (Vol 2 - Amphibians)" includes content: Sex determination and sexual differentiation in amphibians; neuroendocrine control of reproduction in amphibians; testicular structure and control of sperm development in amphibians; hormones and the female reproductive system of amphibians; hormones, sex accessory structures, and secondary sexual characteristics in amphibians,... and other contents.
161p
oursky05
20-09-2023
6
2
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Neuroendocrine carcinomas are extremely rare in the esophagus as they represent less than 0.04% of all neuroendocrine tumors. To date, only 14 cases of poorly differentiated, high-grade esophageal NEC have been described in the literature. The majority of these patients presented with typical dysphagia symptoms.
5p
vidoctorstrange
06-05-2023
3
2
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Experimental studies indicate that neuroendocrine pathways might play a role in progression of breast cancer. We aim to test the hypothesis that somatic mutations in the genes of neuroendocrine pathways influence breast cancer prognosis, through dysregulated gene expression in tumor tissue.
10p
visusanwojcicki
28-06-2022
8
2
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Cytotoxic chemotherapy combinations and targeted agents represent established treatment concepts in advanced pancreatic neuroendocrine tumors (PNETs). However, response rates, side effects and outcome data strongly vary among these therapeutic approaches.
9p
vimahuateng
26-11-2021
4
1
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There are significant sex differences in human physiology and disease; the genomic sources of these differences, however, are not well understood. During puberty, a drastic neuroendocrine shift signals physical changes resulting in robust sex differences in human physiology.
16p
vijeeni2711
24-07-2021
8
1
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Somatostatin analogues (SSAs) are indicated to relieve carcinoid syndrome but seem to have antiproliferative effects on neuroendocrine tumours (NETs). This is the first prospective study investigating tumour stabilisation with the long-acting SSA lanreotide Autogel in patients with progressive NETs.
9p
vijennie2711
29-09-2020
16
2
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We assessed the activity and toxicity of the XELBEVOCT regimen in patients with metastatic well-to-moderately differentiated neuroendocrine neoplasms (WMD-NEN). Ancillary studies evaluated hypertension, proteinuria, and vascular endothelial growth factor (VEGF) polymorphisms in predicting progression-free survival (PFS) and the predictive role of serum vitamin D in progression-free survival and proteinuria onset.
10p
virose2711
25-09-2020
10
0
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