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Non-caseating granulomas

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  • Sarcoidosis is a disease of unknown etiology that is characterized by non-caseating granulomas in multiple organs. It can involve the lung in various forms. Nodular involvement is a rare form of pulmonary sarcoidosis which can be mistaken for malignancy. Diagnosis requires compatible clinical picture along with imaging findings suggestive of the disease and noncaseating granulomas on histopathology.

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  • Thoracic computed tomography scan showed pulmonary nodules and mediastinal and hilar lymphadenopathy. Bronchoalveolar lavage revealed a CD4/CD8 ratio of 8, and lymph node biopsy confirmed noncaseating granulomas. The diagnosis of sarcoidosis with ocular, pulmonary, and neurologic involvement was made.

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