Nucleotide biosynthesis
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Ebook "Fundamentals and application of new bioproduction systems" presents a new bioproduction system as a middle-way between living cells and cell-free systems, namely tailored and permeabilized cells for multienzymatic biosynthesis. Practical examples are described to use this probably more costefficient production system for the synthesis of phosphorylated carbohydrates, sugar nucleotides, and polyketides.
245p coduathanh1122 27-03-2024 1 1 Download
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Part 3 book "Biochemistry" includes content: The biosynthesis of amino acids, nucleotide biosynthesis, the biosynthesis of membrane lipids and steroids, the integration of metabolism, DNA replication, repair, and recombination, RNA synthesis and processing, protein synthesis, the control of gene expression in prokaryotes, the control of gene expression in eukaryotes.
336p oursky07 24-10-2023 9 3 Download
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Ebook Principles of biochemistry (8th edition): Part 3 includes content: Lipid biosynthesis; biosynthesis of amino acids, nucleotides, and related molecules; hormonal regulation and integration of mammalian metabolism III information pathways; genes and chromosomes; DNA metabolism, RNA metabolism; protein metabolism; regulation of gene expression.
1736p oursky05 20-09-2023 5 2 Download
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Continued part 1, part 2 of ebook "Lehninger principles of biochemistry (7th edition)" provides readers with contents including: principles of metabolic regulation; the citric acid cycle; fatty acid catabolism; amino acid oxidation and the production of urea; oxidative phosphorylation; photosynthesis and carbohydrate synthesis in plants; biosynthesis of amino acids, nucleotides, and related molecules;...
1685p lytamnguyet 04-08-2023 5 3 Download
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Continued part 1, part 2 of ebook "Principles of biochemistry (4th edition)" provide readers with content about: glycolysis, gluconeogenesis, and the pentose phosphate pathway; the metabolism of glycogen in animals; the citric acid cycle; fatty acid catabolism; amino acid oxidation and the production of urea; oxidative phosphorylation and photophosphorylation; carbohydrate biosynthesis in plants and bacteria; lipid biosynthesis; biosynthesis of amino acids, nucleotides, and related molecules; integration and hormonal regulation of mammalian metabolism;...
599p hanlinhchi 11-11-2022 19 3 Download
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Genomes are composed of long strings of nucleotide monomers (A, C, G and T) that are either scavenged from the organism’s environment or built from metabolic precursors. The biosynthesis of each nucleotide differs in atomic requirements with different nucleotides requiring different quantities of nitrogen atoms.
15p viaristotle 29-01-2022 34 0 Download
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The Gram-positive bacterium Enterococcus faecium is a commensal of the human gastrointestinal tract and a frequent cause of bloodstream infections in hospitalized patients. The mechanisms by which E. faecium can survive and grow in blood during an infection have not yet been characterized. Here, we identify genes that contribute to growth of E. faecium in human serum through transcriptome profiling (RNA-seq) and a highthroughput transposon mutant library sequencing approach (Tn-seq).
12p vilarryellison 29-10-2021 10 1 Download
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Single nucleotide polymorphisms (SNPs) and insertions/deletions (InDels) are the major genetic variations and are distributed extensively across the whole plant genome. However, few studies of these variations have been conducted in the long-lived perennial tea plant.
16p viansan2711 30-07-2021 6 1 Download
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Brassica napus L. is one of the most important oil crops in the world. However, climate-changeinduced environmental stresses negatively impact on its yield and quality. Cuticular waxes are known to protect plants from various abiotic/biotic stresses.
19p vijichea2711 28-05-2021 5 1 Download
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Starch from maize kernels has diverse applications in human and animal diets and in industry and manufacturing. To meet the demands of these applications, starch quantity and quality need improvement, which requires a clear understanding of the functional mechanisms involved in starch biosynthesis and accumulation.
12p vihashirama2711 21-05-2020 16 1 Download
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Virtually all cells are capable of synthesizing purine and pyrimidine nucleotides. These compounds then serve as essential intermediates in metabolism and as the building blocks for DNA and RNA synthesis. In this chapter you will learn: How do cells synthesize purines and pyrimidines?
53p tangtuy15 30-06-2016 42 4 Download
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Escherichia coli 3-phosphoglycerate dehydrogenase (PGDH) catalyzes the first step in serine biosynthesis, and is allosterically inhibitedby serine. Structural studies revealeda homotetramer in which the quaternary arrangement of subunits formed an elongated ellipsoid. Each subunit consisted of three domains: nucleotide, substrate and regu-latory. InPGDH, extensive interactions are formedbetween nucleotide binding domains.
9p research12 23-04-2013 33 1 Download
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The serotype a-specific polysaccharide antigen ofActinoba-cillus actinomycetemcomitansis an unusual sugar, 6-deoxy-D-talose.Guanosinediphosphate (GDP)-6-deoxy-D-talose is the activated sugar nucleotide form of 6-deoxy-D-talose, which has been identified as a constituent of only a few microbial polysaccharides. In this paper, we identify two genes encoding GDP-6-deoxy-D-talose synthetic enzymes, GDP-a-D-mannose 4,6-dehydratase and GDP-4-keto-6-deoxy-D-mannose reductase, in the gene cluster required for the biosynthesis of serotype a-specific polysaccharide anti-gen from A.
9p tumor12 22-04-2013 29 1 Download
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WhenSaccharomyces cerevisiaecells, grown in galactose, glucose or mannose, were treated with 1.5 mMhydrogen peroxide (H2O2) for 30 min, an important decrease in the ATP, and a less extensive decrease in the GTP, CTP, UTP and ADP-ribose levels was estimated. Concomitantly a net increase in the inosine levels was observed. Treatment with 83mMmenadionepromoted theappearanceof acompound similar to adenosine but no appreciable changes in the nucleotide content of yeast cells, grown either in glucose or galactose....
12p tumor12 20-04-2013 39 2 Download
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High-resolution crystal structures of large ribosomal subunits from Deinococcus radioduranscomplexed with tRNA-mimics indicate that precise substrate positioning, mandatory for efficient protein biosynthesis with no further conformational rearrangements, is governed by remote interactions of the tRNA helical features.
14p fptmusic 16-04-2013 39 2 Download
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Numerous transmembrane proteins, including the blood pressure regulating angiotensin converting enzyme (ACE) and the Alzheimer’s disease amyloid precursor protein (APP), are proteolytically shed from the plasma membrane by metalloproteases. We have used an antisense oligo-nucleotide (ASO) approach to delineate the role of ADAM10 and tumour necrosis factor-aconverting enzyme (TACE;ADAM17) in theectodomainsheddingofACEand APP from human SH-SY5Y cells.
9p dell39 03-04-2013 52 2 Download
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Extracellular nucleotides have a profound role in the regulation of the pro-liferation of diseased tissue. We studied how extracellular nucleotides regu-late the proliferation of LXF-289 cells, the adenocarcinoma-derived cell line from human lung bronchial tumor. ATP and ADP strongly inhibited LXF-289 cell proliferation.
12p inspiron33 25-03-2013 22 3 Download
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The voltage-gated potassium channel Kv4.3 was coexpressed with itsb-sub-unit Kv channel-interacting protein 2 and the angiotensin type 1 receptor in HEK-293 cells. Proteomic analysis of proteins coimmunoprecipitated with Kv4.3 revealed that Kv4.3 is associated with Rap guanine nucleotide exchange factors MR-GEF and EPAC-1.
10p media19 04-03-2013 34 1 Download
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Phosphoglycerate kinase (EC 2.7.2.3) catalyzes reversible phosphoryl trans-fer from 1,3-bisphosphoglycerate to ADP to synthesize 3-phosphoglycerate and ATP during glycolysis. Phosphoglycerate kinases from several sources can use GDP⁄GTP as alternative substrates to ADP⁄ATP; however, the maximal velocities (Vm) reached with the guanine nucleotides are 50% of those displayed with the adenine nucleotides.
11p viettel02 22-02-2013 29 2 Download
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The mitochondrial carriers are a family of transport proteins that shuttle metabolites, nucleotides and cofactors across the inner mitochondrial mem-brane. The genome ofDrosophila melanogasterencodes at least 46 mem-bers of this family. Only five of these have been characterized, whereas the transport functions of the remainder cannot be assessed with certainty.
10p mobifone23 18-01-2013 33 2 Download