Numerous clinical trials

One of the key elements in the early stages of drug discovery is finding good hits to develop lead compounds. Although HTS has been used as a standardized technology for hit finding, it still bears some challenging drawbacks: expensive and low-quality data. Aiming at the same goal as HTS, virtual screening (VS) has been developed to reduce cost and increase efficiency. Recent studies show that VS can deliver numerous quality hits and a few of them even reach clinical trials.

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Injuries and resulting stiffness around joints, especially the elbow, have huge psychological effects by reducing quality of life through interference with normal daily activities such as feeding, dressing, grooming, and reaching for objects. Over the last several years and through numerous research results, the myofibroblast-mast cellneuropeptide axis of fibrosis had been implicated in post-traumatic joint contractures.

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Few targeted therapies (TTs) are registered for sarcoma treatment despite numerous phase II studies and yet there are potential treatment options for patients after standard treatment escape. The French Sarcoma Group - Bone Tumor Study Group (GSF-GETO) created a national registry to evaluate the outcome of patients treated with off-label TTs.

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Venetoclax (ABT-199), a first-in-class orally bioavailable BCL-2-selective inhibitor, was recently approved by the FDA for use in patients with 17p-deleted chronic lymphocytic leukemia who have received prior therapy. It is also being evaluated in numerous clinical trials for treating patients with various hematologic malignancies.

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The status of research, development and application of genetic technology in the US has been reflected through efforts and accomplishments in numerous fields including research, medicine, industrial biotechnology and agriculture in the past decades. In the area of medicine, the field of therapeutic purposes on human is the pioneer, in which gene therapy is attempted to carry out in various clinical trials.

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Therapeutic immunosuppression has very broad applications in clinical medicine, ranging from prevention and treatment of organ and bone marrow transplant rejection, management of various autoimmune disorders (e.g., rheumatoid arthritis), skin diseases, allergies and asthma. Whereas traditionally only a small repertoire of immunosuppressive agents was available for clinical use, recent discoveries have significantly increased the number of approved agents, resulting in numerous trials to further evaluate their potential.

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Osteoclasts Georg Schett Department of Internal Medicine III and Institute for Clinical Immunology, University of Erlangen-Nuremberg, Erlangen, Germany Corresponding author: Georg Schett, Georg.schett@med3.imed.uni-erlangen.de Published: 15 February 2007 This article is online at http://arthritis-research.com/content/9/1/203 © 2007 BioMed Central Ltd Arthritis Research & Therapy 2007, 9:203 (doi:10.1186/ar2110) Abstract Osteoclasts are multinucleated cells of hematopoietic origin and are the primary bone resorbing cells.

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