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Oncogenic human papillomavirus
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Oncogenic Human Papillomaviruses (HPVs) base their transforming potential on the action of both E6 and E7 viral oncoproteins, which perform cooperative or antagonistic actions and thus interfere with a variety of relevant cellular targets.
13p
vialfrednobel
23-12-2023
5
3
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The oncogenic human papillomavirus (HPV) is an excellent biomarker for cervical cancer screening. The present research reports the construction of an integrated sensor platform (biosensorMY11 and biosensorp53) for the impedimetric detection of the HPV L1 sequence and p53 tumor suppressor gene.
9p
viberbers
09-08-2023
6
2
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MicroRNAs have emerged as an important regulator of cell cycle and various other cellular processes. Aberration in microRNAs has been linked with development of several cancers and other diseases but still very little is known about the mechanism by which they regulate these cellular events.
11p
vikolindagrabar
27-07-2022
4
1
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High-risk human papillomavirus (HR-HPV) is the main aetiological factor for the development of cervical cancer. While nearly 70% of HR-HPV infections are cleared within 12 months, in the remainder of women they persist and can progress into cervical cancer.
6p
vipriyankagandhi
27-07-2022
3
1
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Low-risk human papillomavirus (HPV), such as types 6 and 11, is considered non-oncogenic, but these types have been detected in oral cancer tissue samples, suggesting their possible involvement in oral carcinogenesis. Because double infection of high-risk HPV and Epstein-Barr virus (EBV) is known to be involved in oral carcinogenesis, we hypothesized that low-risk HPV and EBV co-infection can transform the oral cells.
13p
vimahuateng
26-11-2021
7
1
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Persistent infection with high-risk human papillomavirus (HR-HPV) is the most important risk factor for the development of cervical cancer, but factors contributing to HR-HPV persistence are incompletely understood.
10p
vianrose2711
27-04-2021
13
2
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High-risk human papillomavirus type 16 (HPV16) is a risk factor for cervical cancer. Previous studies suggest that polymorphisms in the E6 gene or the long control region (LCR)of HPV16 may alter the oncogenic potential of the virus.
8p
vijennie2711
29-09-2020
9
1
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Cervical cancer is the first female cancer in Lao PDR, a low-income country with no national screening and prevention programs for this human papillomavirus (HPV) associated pathology. HIV-infected women have a higher risk of persistent oncogenic HPV infection.
10p
virose2711
25-09-2020
19
0
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Persistent infection with oncogenic Human Papillomavirus (HPV) is associated with the development of cervical cancer with each genotype differing in their relative contribution to the prevalence of cervical disease. HPV DNA testing offers improved sensitivity over cytology testing alone but is accompanied by a generally low specificity.
10p
virose2711
24-09-2020
9
1
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Nearly all uterine cervical cancer (UCC) cases result from human papillomavirus (HPV) infection. After high-risk HPV infection, most HPV infections are naturally cleared by humoral and cell-mediated immune responses. Thus, cervical lesions of only few patients progress into cervical cancer via cervical intraepithelial neoplasia (CIN) and lead to persistent oncogenic HPV infection.
7p
vitokyo2711
31-08-2020
11
2
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Human papillomavirus DNA detection in head and neck squamous cell carcinoma has been linked to improved patient prognosis. The main aims of the study was to test the hypotheses that HPV16 E6/E7 oncogene and p53 function within tumours were associated with the widely reported improved patient survival and prognosis in head and neck cancer.
11p
vinaypyidaw2711
26-08-2020
6
2
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The aims of this study were to detect HPV E6/E7 mRNA expression in women with high-risk genotypes (HPV-16, -18, -31, -33 and -45) analysing its relationship with tissue pathology and 2) 2-year follow-up of E6/E7 mRNA tested group.
7p
vimale2711
25-08-2020
11
2
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Human papillomavirus (HPV) 16 and 18 are the two most common HPV oncogenic types that can be prevented by vaccination. This study aimed at assessing the cost-effectiveness of 3 doses of the bivalent HPV vaccine in rural and urban settings in China.
12p
vimale2711
25-08-2020
12
2
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The new nine-valent vaccine against human papillomavirus (HPV) includes the four HPV genotypes (6, 11, 16, and 18) that are targeted by the older quadrivalent HPV vaccine, plus five additional oncogenic types (31, 33, 45, 52, and 58) remain significantly associated with high grade lesions.
9p
vibaku2711
22-07-2020
14
2
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Oncogenic viruses are the known etiologic agents in 15% – 20% of all human cancers. Their impact on global health is signifi cant. The fi rst recognition that cancer can be caused by a virus dates back to observations of Rous sarcoma virus in chickens almost 100 years ago. However, it was not until the 1970s that the mechanistic basis for retroviral transformation became clearer. That era was marked by the discovery of many viral oncogenes and counterpart cellular proto - oncogenes.
510p
hyperion75
18-01-2013
46
7
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