Onset timing
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In cancer, normal epigenetic patterns are disturbed and contribute to gene expression changes, disease onset, and progression. The cancer epigenome is composed of the epigenetic patterns present in the tumor-initiating cell at the time of transformation, and the tumor-specific epigenetic alterations that are acquired during tumor initiation and progression.
19p vibransone 28-03-2024 4 2 Download
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Controversy exists regarding the relationship of the outcome of patients with colorectal cancer (CRC) with the time from symptom onset to diagnosis. The aim of this study is to investigate this association, with the assumption that this relationship was nonlinear and with adjustment for multiple confounders, such as tumor grade, symptoms, or admission to an emergency department.
13p vialfrednobel 23-12-2023 6 4 Download
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The timing of events in the management of osteosarcoma may be critical for patient survivorship; however, the prognostic value of factors such as onset of symptoms or initiation of therapy in these patients has not been studied. This study sought to review the literature reporting treatment of osteosarcoma to determine the utility of event timing as a prognostic indicator.
8p vialfrednobel 23-12-2023 3 3 Download
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Patients presenting with inoperable colon cancer at first onset (ICF) or at time of relapse (ICR) are considered in unrecoverable. The therapeutic goal for unrecoverable cancer is to prolong overall survival (OS) and maintain a high quality of life (QOL).
7p visharma 20-10-2023 4 2 Download
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Cardiotoxicity is among the most important adverse effects of childhood cancer treatment. Anthra‑ cyclines, mitoxantrone and radiotherapy involving the heart are its main causes. Subclinical cardiac dysfunction may over time progress to clinical heart failure.
26p vioracle 29-09-2023 7 2 Download
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This case highlights the importance of identifying relevant past medical history on initial assessment, and having rapid access to radiology and orthopedic support to enable timely diagnosis, as prognosis becomes poorer as age increases. Perthes-like changes should be considered as a differential diagnosis in patients presenting with non-traumatic hip pain, regardless of age of onset.
7p viintuit 26-09-2023 4 0 Download
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Lung involvement in inflammatory bowel diseases usually follows colitis. However, the time to lung involvement onset varies depending on the case, and pulmonary lesions are usually not parallel to exacerbations of the colitis.
6p vigamora 23-05-2023 4 2 Download
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The time interval from first symptom and sign until a cancer diagnosis significantly affects the prognosis. Therefore, recognising and acting on signs of cancer, such as anaemia, is essential.
13p vikolindagrabar 27-07-2022 4 2 Download
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Rocuronium bromide (RB) is known to cause vascular pain. Although there have been a few reports that diluted administration causes less vascular pain, there have been no studies investigating diluted administration and the onset time of muscle relaxation. Therefore, we examined the influence of diluted administration of RB on the onset time of muscle relaxation and vascular pain.
6p vizhangzhidong 29-12-2021 6 0 Download
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To compare the application and efficacy of ropivacaine combined with sufentanil for continuous epidural anesthesia (CEA) and combined spinal-epidural anesthesia (CSEA) in labor analgesia. Considering ropivacaine combined with sufentanil for CSEA achieved a shorter onset time and labor period, significant analgesic effect, lower adverse drug reactions rates and higher subject satisfaction than CEA, it may be worthy of clinical promotion and application.
5p vizhangzhidong 29-12-2021 8 0 Download
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The optimum growth time was acquired to be 11 hours. Thereby such obtained electrode exhibited the maximum HER activity with onset over the potential of 220 mV versus reversible hydrogen electrode (RHE), and the Tafel slope of 66 mV per decade (mV/dec). Conclusion: Our results suggest a good technique for the research of high-efficient HER electrocatalyst based on atomicthickness layered materials.
7p spiritedaway36 28-11-2021 3 1 Download
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Immunotherapy is becoming a standard of care for non-small cell lung cancer (NSCLC). Checkpoint inhibitor-associated pneumonia (CIP) is a rare and potentially life-threatening event that can occur at any time during tumor immunotherapy. However, there may be differences in the radiological patterns and prognosis of CIP during different periods.
9p vimahuateng 26-11-2021 10 0 Download
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International differences in survival among colorectal cancer (CRC) patients may partly be explained by differences in emergency presentations (EP), waiting times and access to treatment.
18p vimahuateng 26-11-2021 7 1 Download
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Babesia rossi is a leading cause of morbidity and mortality among the canine population of subSaharan Africa, but pathogenesis remains poorly understood. Previous studies of B. rossi infection were derived from clinical cases, in which neither the onset of infection nor the infectious inoculum was known.
16p vitzuyu2711 29-09-2021 6 1 Download
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High temperature during grape berry ripening impairs the quality of fruits and wines. Veraison time, which marks ripening onset, is a key factor for determining climatic conditions during berry ripening. Understanding its genetic control is crucial to successfully breed varieties more adapted to a changing climate.
19p visilicon2711 20-08-2021 11 1 Download
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Attenuated decreases in lung function can signal the onset of acute respiratory events known as pulmonary exacerbations (PEs) in children and adolescents with cystic fibrosis (CF). Univariate joint modeling facilitates dynamic risk prediction of PE onset and accounts for measurement error of the lung function marker.
11p vimaine2711 26-03-2021 7 1 Download
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Honeycombing on high-resolution computed tomography (HRCT) is a distinguishing feature of usual interstitial pneumonia and predictive of poor outcome in interstitial lung diseases (ILDs). Although fine crackles are common in ILD patients, the relationship between their acoustic features and honeycombing on HRCT has not been well characterized.
8p vimaine2711 26-03-2021 6 2 Download
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Methotrexate (MTX) is standard treatment for RA. Absorption is better in subcutaneous MTX (scMTX), which may impact speed of onset. In RA, earlier time to remission improves long-term results. Our objectives were to determine rapidity of response of subcutaneous methotrexate in early rheumatoid arthritis.
7p vioregon2711 22-02-2021 7 2 Download
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Neck and low back pain represent dynamic conditions that change over time, often with an initial improvement after the onset of a new episode, followed by flare-ups or variations in intensity. Pain trajectories were previously defined based on longitudinal studies of temporal patterns and pain intensity of individuals with low back pain.
14p vimariana2711 22-12-2020 9 1 Download
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The study has designed a process to record dozing-off event, then constructed and implemented the hypnogram processing program that evaluated quantitative changes in polysomnography signals at sleep onset, the transition time from wake stage to sleep stage. By analyzing the energy spectrum of the signal and using wavelet transform in combine with the support vector machine algorithm, the research allows a comprehensive evaluation of the state of dozing-off. Determining the exact time of onset of sleep is very important in the study of drowsiness.
5p trinhthamhodang9 04-12-2020 8 2 Download