Opioid receptors
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Part 2 book "Veterinary psychopharmacology" includes content: Anticonvulsants and mood stabilizers, sympatholytic agents, n‐methyl‐d‐aspartate (NMDA) receptor antagonists, monoamine oxidase inhibitors, antipsychotics, CNS stimulants, tricyclic antidepressants, opioids and opioid antagonists, hormones, combinations.
158p oursky07 24-10-2023 7 3 Download
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Part 2 book "Veterinary psychopharmacology" includes content: Miscellaneous serotonergic agents, anticonvulsants and mood stabilizers, sympatholytic agents, N‐Methyl‐D‐Aspartate (NMDA) receptor antagonists, monoamine oxidase inhibitors, antipsychotics, combinations, hormones, opioids and opioid antagonists, tricyclic antidepressants, CNS stimulants.
176p oursky05 20-09-2023 5 1 Download
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Perioperative opioid use is associated with postoperative bowel dysfunction, which causes longer hospital stay and higher healthcare costs. This study aimed to investigate the effect of the equivalent doses of fentanyl, oxycodone, and butorphanol on bowel function in patients undergoing laparoscopic hysterectomy.
8p viisaacnewton 26-04-2022 5 1 Download
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Delta-opioid receptor is widely expressed in human and rodent hearts, and has been proved to protect cardiomyocytes against ischemia/reperfusion and heart failure. The antagonist of delta-opioid receptor could block the rescue effect of lipid emulsion against local anesthetic cardiotoxicity.
6p viisaacnewton 26-04-2022 13 1 Download
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Even extremely high-doses of the potent opioid, sufentanil, cannot reliably suppress stress responses to intense surgical stimuli such as sternotomy. The chemically related opioid remifentanil with its different pharmacokinetics and binding affinities for delta- and kappa-opioid receptors might be more effective in attenuating these responses.
8p viisaacnewton 26-04-2022 5 1 Download
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Activation of NMDA receptors play an important role in the development of remifentanil-induced hyperalgesia. We hypothesized that in addition to ketamine, intrathecal MgSO4 could also relieve thermal and mechanical hyperalgesia in rats.
8p viottohahn 30-03-2022 11 1 Download
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Meperidine is a synthetic opioid that belongs to the phenylpiperidine class and is a weak mu receptor agonist. In horses there are a limited number of published studies describing the analgesic effects of systemically administered meperidine in horses. The objective of this study was to describe the pharmacokinetics, behavioral and physiologic effects and effect on thermal threshold of three doses of intravenously administered meperidine to horses.
12p vigandhi 23-02-2022 10 1 Download
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Sufentanil is one of the opioids currently used to induce general anesthesia, and cough is one of the most common complications. Many drugs have been used to prevent sufentanil-induced cough (SIC), and dezocine is one of them. Dezocine is an analgesic, acting as partial antagonist of κ-receptors and agonist of μ-receptors. The purpose of our meta-analysis is to evaluate the efficacy of dezocine on SIC.
10p vizhangzhidong 29-12-2021 11 0 Download
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In this study, the μ-Opioid receptor activity was assessed pre-operatively for its association with postoperative pain level and second analgesic requirement in patients undergoing septoplasty. Methods: In our prospective study, 120 adult patients underwent septoplasty from June 2015 to January 2019 were randomly divided into 2 pre-operative groups.
8p vizhangzhidong 29-12-2021 13 0 Download
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In different models of hypoxia, blockade of opioid or N-methyl-D-aspartate (NMDA) receptors shows cardio- and neuroprotective effects with a consequent increase in animal survival. The aim of the study was to investigate effects of pre-treatment with Morphine or Ketamine on hemodynamic, acid-base status, early survival, and biochemical markers of brain damage in a rat model of asphyxial cardiac arrest (ACA).
9p vizhangzhidong 29-12-2021 17 1 Download
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Perioperative immune function plays an important role in the prognosis of patients. Several studies have indicated that low-dose opioid receptor blockers can improve immune function. Methods: Sixty-nine patients undergoing video-assisted thoracoscopic resection of the lung cancer were randomly assigned to either the naloxone group (n = 35) or the non-naloxone group (n = 34) for postoperative analgesia during the first 48 h after the operation.
9p vizhangzhidong 29-12-2021 14 0 Download
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Buprenorphine, a partial opioid agonist, displaces full opioid agonists from receptors and may impede surgical pain management. We report the effects of a sublingual formulation of buprenorphine-naloxone, Suboxone (SL-BUP), on perioperative pain management.
7p vizhangzhidong 29-12-2021 13 0 Download
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Opioid receptors are implicated in cell proliferation and cancer migration. However, the efects and underlying mechanisms of opioid receptor κ (OPRK1) in breast cancer remain unknown. Methods: Small interfering RNA (siRNAs) was used to knockdown the expression of OPRK1. Western blot was used to determine the protein expression and reverse transcription-quantitative PCR (RT-qPCR) determined the genes transcription.
10p vidietmarhopp 29-12-2021 18 0 Download
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Angiogenesis, the formation of blood vessel from pre-existing ones, plays an important role in many pathophysiological diseases, such as cancer. Opioids are often used in clinic for the management of chronic pain in cancer patients at terminal phases. Here, we investigated and compared the efects and mechanisms of four opioids on angiogenesis.
10p vidietmarhopp 29-12-2021 17 0 Download
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Clinically, the coadministration of opioids to enhance antinociception and decrease tolerance has attracted increasing research attention. We investigated the effects of dezocine, a mu- and kappa-opioid receptor agonist/antagonist, on morphine tolerance and explored the involvement of opioid receptor expression in a rat model of bone cancer pain.
10p vimahuateng 26-11-2021 5 0 Download
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Earlier observations show that development of persistent pain may be associated with the genetic variability in the gene encoding for the μ-opioid receptor 1, the OPRM1 A118G (rs1799971). The aim of this study was to investigate the association between OPRM1 genotype and subjective health complaints in patients with radicular pain and disc herniation.
6p viannito2711 20-04-2021 9 2 Download
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Opioid receptors have become increasingly implicated in cancer progression and long-term patient outcomes. However, the expression and significance of the κ-opioid receptor (KOR) in hepatocellular carcinoma (HCC) remain unclear.
11p vidhaka2711 31-07-2020 11 1 Download
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This commentary highlights the recent work published in journal Nature on the structural based discovery of novel analgesic compounds for opioid receptors with minimal effects.
3p vijiraiya2711 27-05-2020 7 1 Download
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In vitro pharmacology of ligands is typically assessed using a variety of molecular assays based on predetermined molecular events in living cells. Many ligands including opioid ligands pose the ability to bind more than one receptor, and can also provide distinct operational bias to activate a specific receptor.
18p vienzym2711 03-04-2020 10 2 Download
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To investigate the structural function of the C-terminal amide group of endomorphin-2 (EM2, H-Tyr-Pro-Phe-Phe-NH2), an endogenous l-opioid receptor ligand, the solution conformations of EM2 and its C-terminal free acid (EM2OH, H-Tyr-Pro-Phe-Phe-OH) in TFE (trifluoroethanol), water (pH 2.7 and 5.2), and aqueous DPC (dodecylphosphocholine) micelles (pH 3.5 and 5.2) were investigated by the combination of 2D 1 H-NMR meas-urement and molecular modelling calculation.
19p fptmusic 12-04-2013 30 2 Download