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Optimizing therapeutic outcomes
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Brain metastases (BMs) are the most frequent intracranial tumours associated with poor clinical outcomes. Radiotherapy is essential in the treatment of these tumours, although the optimal radiation strategy remains controversial. The present study aimed to assess whether whole brain radiation therapy with a simultaneous integrated boost (WBRT + SIB) provides any therapeutic beneft over WBRT alone.
12p
vileonardodavinci
23-12-2023
6
3
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In 2010, the Canadian province of British Columbia (BC) initiated the Seek and Treat for Optimal Prevention of HIV/AIDS (STOP HIV/AIDS) program to improve HIV testing, linkage to care, and treatment uptake, thereby operationalizing the HIV Treatment as Prevention (TasP) framework at the population-level. In this analysis, we evaluated self-reported HIV care experiences and therapeutic outcomes among people diagnosed with HIV prior to and after implementation of this provincial program.
12p
viferrari
28-11-2022
8
2
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Extracorporeal membrane oxygenation (ECMO) is a supportive therapy and its success depends on optimal drug therapy along with other supportive care. Emerging evidence suggests significant interactions between the drug and the device resulting in altered pharmacokinetics (PK) of vital drugs which may be further complicated by the PK changes that occur in the context of critical illness.
10p
viisaacnewton
26-04-2022
16
1
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A primary pulmonary invasive mucinous adenocarcinoma (IMA) is a rare subtype of invasive adenocarcinoma of the lung. The prognosis of advanced IMA depending on chemotherapy regimen has not been fully investigated. Here, we compared the clinical outcomes of patients with advanced IMA treated with different palliative chemotherapies that included novel therapeutics.
9p
vimahuateng
26-11-2021
18
0
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By investigating treatment patterns and outcomes in locally advanced head and neck squamous cell carcinoma (LA-HNSCC), we aimed at providing valuable insights into the optimal therapeutic strategy for physicians in real-world practice.
9p
vimoscow2711
29-08-2020
12
2
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The optimal therapeutic strategy in UICC stage T3 hepatocellular carcinoma (HCC) patients that maximizes both safety and long-term outcome has not yet been determined. Our aim was to compare clinical outcomes following hepatic resection (HR) versus transarterial chemoembolization (TACE) for stage T3 HCC.
10p
vibaku2711
22-07-2020
13
2
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High-grade salivary gland cancer is a distinct clinical entity that has aggressive disease progression and early systemic spread. However, because of the rarity of the disease, the clinical outcomes, prognostic factors and clinical decision on the optimal treatments have not been fully understood.
12p
vibaku2711
22-07-2020
28
1
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One of the most commonly used vectors for gene therapy is the adenoviral vector; its ability to tightly regulate transgene expression is critical for optimizing therapeutic outcomes.
8p
viuchiha2711
21-04-2020
17
1
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Discovery of a new chemical entity that exerts pharmacological effects for curing or treating diseases or relieving symptoms is only the first step in the drug developmental process. In the developmental cycle of a new drug, the delivery of a desired amount of a therapeutic agent to the target at a specific time or duration is as important as its discovery. In order to realize the optimal therapeutic outcomes, a delivery system should be designed to achieve the optimal drug concentration at a predetermined rate and at the desired location....
0p
echbuon
02-11-2012
57
2
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There have been major changes in attitudes towards schizophrenia in recent years. In clinical practice, more effective pharmacological and psychological treatments for schizophrenia have helped regenerate a sense of therapeutic optimism. In research, progress in a range of basic disciplines has opened up new avenues which promise to help unravel the abnormalities of brain development, structure and function which are at the core of the disorder.
89p
951864273
10-05-2012
72
8
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Harrison's Internal Medicine Chapter 5. Principles of Clinical Pharmacology Principles of Clinical Pharmacology: Introduction Drugs are the cornerstone of modern therapeutics. Nevertheless, it is well recognized among physicians and among the lay community that the outcome of drug therapy varies widely among individuals. While this variability has been perceived as an unpredictable, and therefore inevitable, accompaniment of drug therapy, this is not the case.
5p
tubreakdance
26-11-2010
104
7
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