Oral agents
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5-Fluorouracil (5FU) is a primary chemotherapeutic agent used to treat oral squamous cell carcinoma (OSCC). However, the development of drug resistance has significantly limited its clinical application. Therefore, there is an urgent need to determine the mechanisms underlying drug resistance and identify effective targets.
16p vishanshan 27-06-2024 2 1 Download
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Ebook Anti-diabetes mellitus plants: Active principles, mechanisms of action and sustainable utilization - Part 1 includes content: Introduction, anti-diabetes mellitus phytochemicals, mechanism of action of anti-diabetes mellitus plants. Invite you to consult the details.
201p longtimenosee03 01-02-2024 2 0 Download
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Sodium–glucose cotransporter 2 inhibitors are among the new-generation oral antihyperglycemic agents that have been used in the treatment of type 2 diabetes mellitus. With the recent coronavirus disease 2019 pandemic and rise of cases in the third wave, diagnosis of life-threatening euglycemic diabetic ketoacidosis may easily be overlooked or missed.
5p vigojek 02-02-2024 4 1 Download
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Part 2 book "BSAVA manual of canine and feline anaesthesia and analgesia" includes content: Inhalant anaesthetic agents; neuromuscular blocking agents; haemodynamic support during the anaesthetic period; fluid therapy and blood transfusion 19. ophthalmic surgery; dental and oral surgery; cardiovascular disease; respiratory compromise; intrathoracic surgery and interventions; gastrointestinal, laparoscopic and liver procedures,... and other contents.
259p muasambanhan04 07-01-2024 5 2 Download
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Ebook "Microbial biofilms: Omics biology, antimicrobials and clinical implications" is a comprehensive survey of microbial biofilms and their role in human health and disease with contributions from world renowned experts in molecular microbiology, proteomics, genomics, metabolomics and infectious diseases. The book is intended to serve as a guide for students, as well as a reference for researchers, clinicians and industry professionals.
291p lucchinguyen 28-12-2023 6 4 Download
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The objective of this study was to investigate the tolerance of capecitabine, an example of oral chemotherapy, among older adults with cancer and explore factors associated with capecitabine-related side effects and treatment changes, to enhance supportive care.
14p vialfrednobel 23-12-2023 5 4 Download
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Metastatic castration-resistant prostate cancer (mCRPC) remains a therapeutic challenge and evidence for late-line treatments in real-life is limited. The present study investigates the efficacy and safety of an oral metronomic chemo-hormonal regimen including cyclophosphamide, etoposide, estramustine, ketoconazole and prednisolone (KEES) administered in a consecutive biweekly schedule.
10p vischultz 20-10-2023 5 2 Download
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Elizabethkingia meningoseptica is an uncommon pathogen that has been associated with nosocomial infections and can pose a therapeutic challenge. It is resistant to most conventional agents used in treatment of gram-negative organisms and as such use of these agents may be unfavorable.
3p viintuit 26-09-2023 1 0 Download
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Functional genetic variation plays an important role in predicting patients’ response to chemotherapeutic agents. A growing catalogue of mitochondrial DNA (mtDNA) alterations in various cancers point to their important roles in altering the drug responsiveness and survival of cancer cells.
4p vihagrid 30-01-2023 9 4 Download
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Tramadol is an atypical centrally acting analgesic agent available as both oral and parenteral preparations. For patients who are unable to take tramadol orally, the subcutaneous route of administration offers an easy alternative to intravenous or intramuscular routes.
8p viisaacnewton 26-04-2022 7 1 Download
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Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Porcine Circovirus Type 2 (PCV2) and Hepatitis E virus (HEV) are common and economically important viral disease causative agents detected in pig oral fluid (OF), faeces and serum at some infection stages.
8p vigandhi 23-02-2022 14 1 Download
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5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil during chemotherapy, 5- fluorocytosine can be used as a targeted anticancer agent.
10p vidarwin 23-02-2022 12 1 Download
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Mycoplasma agalactiae, causing agent of contagious agalactia, infects domestic small ruminants such as sheep and goats but also wild Caprinae. M. agalactiae is highly contagious and transmitted through oral, respira‑ tory, and mammary routes spreading rapidly in an infected herd.
9p vidarwin 22-02-2022 12 1 Download
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The purpose of this study was to examine whether the administration of nickel (Ni) was associated with cell apoptosis and also to evaluate whether post acute oral exposure to hyperoside would cause histopathologic alterations in rats. Four groups of male SpragueDawley rats (n = 7) used in this study were as follows: a control group and groups treated with Ni (as NiCI2, 13 mg/kg), hyperoside (Hyp) (50 mg/kg), and Ni + Hyp.
10p dolomite36 30-12-2021 6 0 Download
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In silico studies reports that their physicochemical, ADMET and druglikeness properties were found to be in standard limit, which infers that, these compounds may not have problems with oral bioavailability. Molecular docking studies showed that the pyrimidines have better enzyme inhibitory activity onTMPKmt.
4p mudbound 10-12-2021 7 1 Download
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Mycobacterium avium subsp. paratuberculosis (MAP), the etiologic agent of Johne’s disease is spread between cattle via the fecal-oral route, yet the functional changes in the salivary gland associated with infection remain uncharacterized.
13p visilicon2711 20-08-2021 10 1 Download
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Evaluation of in vivo antidiabetic activity of umbelliferone in streptozotocin induced diabetic rats
The first line of treatment in Diabetes mellitus includes the use of oral hypoglycemic agents which are associated with several side effects. Herbal agents are known for their effectiveness due to their fewer side effects and relatively low cost. Umbelliferone, a coumarin has been reported to reduce or decrease blood glucose, elevated plasma insulin, protein profile, and cause hypolipidemic effect. Six groups of rats were used as control, diabetic control, umbelliferone at 20 mg/kg b.wt., umbelliferone at 40 mg/kg b.wt. and combination of glibenclamide and umbelliferone at 20 mg/kg b. wt.
12p caygaocaolon11 21-04-2021 13 0 Download
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Tranexamic acid (TXA) is an anti-fibrinolytic agent successfully preventing blood loss when using intravenously (IV) in total hip arthroplasty (THA) and total knee arthroplasty (TKA). An oral administration, which is available on blood sparing, has been reported exhibit profound cost-saving benefits.
7p vivermont2711 28-01-2021 8 1 Download
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Metformin, which is widely used as an antidiabetic agent, has recently been reported to reduce cancer risk and improve prognosis in certain malignancies. However, the specific mechanisms underlying the effect of metformin on the development and progression of several cancers including oral squamous cell carcinoma (OSCC) remain unclear.
10p vijisoo2711 30-09-2020 8 1 Download
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With the remarkable improvements in ultrasound equipment, transabdominal ultrasound after oral administration of an echoic cellulose-based gastric ultrasound contrast agent (TUS-OCCA) has recently been suggested to be effective in initial screening of gastric cancer.
8p vimoscow2711 29-08-2020 11 1 Download