Oral anti-fungal agent

5-fluorocytosine is a pyrimidine and a fluorinated cytosine analog mainly used as an antifungal agent. It is a precursor of 5-fluorouracil, which possesses anticancer properties. To reduce systemic toxicity of 5-fluorouracil during chemotherapy, 5- fluorocytosine can be used as a targeted anticancer agent.

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Candida species is the only fungal pathogen that causes variety of afflictions that ranges from superficial mucosal infections to life-threatening disseminated mycoses. Oral candidiasis is a common fungal infection caused by an overgrowth or infection due to Candida spp. Candida albicans is considered as the primary etiology of various clinical types of candidiasis including oral lesions. However, in recent years research studies have highlighted the greater recognition of non-albicans Candida (NAC) spp.

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Candidiasis: Treatment Treatment involves removing any predisposing factors such as antibiotic therapy or chronic wetness and the use of appropriate topical or systemic antifungal agents. Effective topicals include nystatin or azoles (miconazole, clotrimazole, econazole, or ketoconazole). The associated inflammatory response accompanying candidal infection on glabrous skin can be treated with a mild glucocorticoid lotion or cream (2.5% hydrocortisone).

5p konheokonmummim 30-11-2010 88 4   Download