Oral drug delivery

Part 2 book "Recent advances in novel drug carrier systems" includes content: Nanocarrier systems for transdermal drug delivery; oral delivery of insulin - novel approaches; novel mucoadhesive polymers for nasal drug delivery; amphiphilic cyclodextrins, synthesis, utilities and application of molecular modeling in their design; processing and templating of bioactive loaded polymeric neural architectures - challenges and innovative strategies; novel drug delivery systems for modulation of gastrointestinal transit time,... and other contents.

260p muasambanhan09 16-03-2024 7 1   Download

As science and technology has developed, the manner by which drugs can be delivered has grown. Medicines may be taken orally, applied as topical pastes, creams or oils, patches or administered by direct injection to the body. This research explores an alternative method for the delivery of therapeutic compounds to the body. The basis of the study involves the application of traditional medicinal compounds used to cure minor neck and back pains through transdermal topical application, using a textile substrate as the carrier.

128p runthenight07 01-03-2023 8 2   Download

In this review article, nano drug delivery systems including nanovesicles, inorganic nanoparticles, lipidbased nanoparticles, polymeric nanoparticles, nanocrystals, nanoemulsions, and microemulsions, which can deliver Andrographolide through different routes such as oral, injection, or dermal, and their influences in increasing treatment benefits are presented.

7p vimalfoy 08-02-2023 3 1   Download

In the present work, hybrid microgels based on chitosan and SiO2 nanoparticles (NPs) were synthesized. Both chitosan and the SiO2 NPs were submitted to chemical modification reactions to having vinyl groups incorporated into their structures.

10p viginny 30-12-2022 8 2   Download

The recent pharmaceutical interest toward confinement effects on the physical state, solubility and release of drugs has paved the way to new material designs for drug delivery. Deeper understanding on how the pore size or the additional functionalities of the nanocarriers can influence the bioavailability of the cargo is nonetheless needed to explore further the potential of nanocarriers in this area.

8p vironald 15-12-2022 11 2   Download

The concept of personalized therapy has been proven to be a promising approach. A popular technique is to utilize gold nanoparticles (AuNPs) as drug delivery vectors for cytotoxic drugs and small molecule inhibitors to target and eradicate oral cancer cells in vitro and in vivo.

16p vianrose2711 27-04-2021 11 2   Download

Doxorubicin hydrochloride (DOX·HCl), an anthracycline glycoside antibiotic, exhibits low oral bioavailability due to active efflux from intestinal P-glycoprotein receptors. The oral administration of DOX remains a challenge hence; no oral formulation for DOX is marketed, till date.

14p vijiraiya2711 27-05-2020 14 1   Download

To improve the solubility and oral bioavailability of erlotinib, a poorly water-soluble anticancer drug, solid self-emulsifying drug delivery system (SEDDS) was developed using solid inert carriers such as dextran 40 and Aerosil® 200 (colloidal silica). The preliminary solubility of erlotinib in various oils, surfactants, and co-surfactants was determined. Labrafil M2125CS, Labrasol, and Transcutol HP were chosen as the oil, surfactant, and co-surfactant, respectively, for preparation of the SEDDS formulations. The ternary phase diagram was evaluated to show the self-emulsifying area.

8p caothientrangnguyen 09-05-2020 13 1   Download

Quercetin (QT) as a bioactive flavonoid has a potential therapeutic activity for numerous neuronal injuries and neurodegenerative diseases. However, the low absorption rate of QT, especially through the bloodbrain barrier, restricts its bioactivity in the body.

12p vimax2711 30-03-2020 9 1   Download

Nanotechnology is now considered a promising drug delivery method for orally administered hydrophobic drugs to their sites of action. The effect of nanodispersion on cellular transport and accumulation of saquinavir (SQV) was investigated.

10p vimax2711 30-03-2020 12 2   Download

Timolol maleate (TiM), a nonselective b-adrenergic blocker, is a potent highly effective agent for management of hypertension. The drug suffers from extensive first pass effect, resulting in a reduction of oral bioavailability (F%) to 50% and a short elimination half-life of 4 h; parameters necessitating its frequent administration. The current study was therefore, designed to formulate and optimize the transfersomal TiM gel for transdermal delivery.

11p kequaidan1 16-11-2019 19 2   Download

BCS class III drugs suffer from a drawback of low permeability even though they have high aqueous solubility. The objective of current work was to screen the suitability of glyceryl monooleate (GMO)/Pluronic F127 cubic phase liquid crystals precursors for permeation enhancement and in turn the bioavailability of tenofovir disoproxil fumarate (TDF), a BCS class III drug. Spray-drying method was used for preparation of TDF loaded liquid crystal precursors (LCP) consisting of GMO/Pluronic F127 and lactose monohydrate with an ability to in situ transform into stable cubic phases upon hydration.

10p trinhthamhodang1 14-11-2019 13 0   Download

A great number of patients have difficulty swallowing or needle fear. Therefore, buccal and orodispersible dosage forms (ODFs) represent an important strategy to enhance patient compliance. Besides not requiring water intake, swallowing or needles, these dosage forms allow drug release modulation. ODFs include oral lyophilizates or wafers, which present even faster disintegration than its compressed counterparts. Lyophilization can also produce buccal wafers that adhere to mucosa for sustained drug release.

9p caygaocaolon1 13-11-2019 23 1   Download

In an attempt to improve material properties used for oral administration, which is restricted by fast dissolution in the stomach, chitosan hydrogels were coated with cellulose dissolved in ionic liquid. Using insulin as a model compound, the properties of these cellulose-coated microparticles for the controlled release of drug were investigated. The results showed that the coated microparticles were more stable than those which were uncoated at low pH and suitable for oral delivery without requiring any harmful and sophisticated cross-linkage treatment.

8p quaymax4 05-09-2018 31 0   Download

The lack of human resource capacity is by far the greatest barrier to overall health sector delivery and has been recognized as a major constraint in attaining the health-related Millennium Development Goals. With 0.03 doctors and 0.21 nurses per 1000 inhabitants, 8 Mozambique has one of the lowest health worker densities in Africa. This is as a result of low pre-service training and recruitment, increased attrition, and rapidly-changing health needs. Health staff distribution around the country still shows considerable regional asymmetries.

86p nhamnhiqa 01-03-2013 45 1   Download

Despite massive efforts in drug discovery fueled by combinatory chemistry, recombinant DNA technology, and highthroughput screening, surprisingly few molecules make it through the drug development process. While the reasons are debated, it is certain that many new chemical entities (NCEs) suffer from recurring problems that hinder development— low water solubility, instability, or inadequate pharmacokinetics. An estimated 43% of NCEs are poorly water-soluble.

679p thuytienvang_1 31-10-2012 65 10   Download