Oral metformin
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Metformin is an oral antidiabetic drug from the biguanide class and it is the first-line drug chosen for the treatment of type 2 diabetes. This is a drug on the list of pharmaceutical substances required to report bioequivalence study data when registering the drug. Objectives: (1) To develope a capillary zone electrophoresis method for determining metformin hydrochloride in human plasma. (2) To validate the method.
10p viangelamerkel 18-07-2022 7 2 Download
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Metformin hydrochloride is a biguanide derivative that has been widely used to treat type 2 diabetes in humans. In veterinary medicine, metformin has shown increasing potential for diabetes treatment in different species, such as equids, dogs, cats and rabbits.
11p vidarwin 22-02-2022 9 1 Download
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In this study, using the connectivity map program, it was determined that metformin and tolbutamide used in the treatment of type II diabetes had the potential to inhibit Rho kinase. In the experimental results to confirm this data, it has been shown that metformin and tolbutamide decrease the cell area within 24 h and metformin inhibits the activation of Rho kinase in MCF-7 cells. These results indicate that metformin, which is used in the treatment of type II diabetes, acts as a ROCK inhibitor.
11p thiencuuchu 27-11-2021 15 1 Download
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Metformin, which is widely used as an antidiabetic agent, has recently been reported to reduce cancer risk and improve prognosis in certain malignancies. However, the specific mechanisms underlying the effect of metformin on the development and progression of several cancers including oral squamous cell carcinoma (OSCC) remain unclear.
10p vijisoo2711 30-09-2020 8 1 Download
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Metformin is a biguanide oral hypoglycaemic agent commonly used for the treatment of type 2 diabetes mellitus. In addition to its anti-diabetic effect, metformin has also been associated with a reduced risk of cancer incidence of a number of solid tumours, including prostate cancer (PCa).
12p vidhaka2711 31-07-2020 9 1 Download
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Diabetes is a metabolic disorder due to insufficiency of insulin (absolute/relative) and generally classified as IDDM and NIDDM. Present study was conducted to observe the anti-diabetic effect of Morinda citrifolia fruit juice. 48 wistar rats of either sex comprising of four groups were taken for the study. Three groups of 36 rats was induced diabetes with single i/p administration of 5% w/v of alloxan monohydrate in normal saline. One group was kept as healthy control (Group-I) and one as diabetic control (Group-II).
8p angicungduoc6 20-07-2020 15 1 Download
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Non-muscle-invasive bladder cancer (NMIBC) is the most common neoplasm of the urinary tract and requires life-long invasive surveillance to detect disease recurrence. Currently, there are no effective oral therapies that delay disease recurrence or progression.
9p vikuala271 13-06-2020 31 1 Download
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Highly sensitive and selective liquid chromatography/tandem mass spectrometry (LC–MS/MS) method was developed and validated for the simultaneous estimation of the recently approved oral hypoglycemic mixture; metformin (MET) and canagliflozin (CFZ) in human plasma using propranolol HCl (PPL) and tadalafil (TDF) as internal standards (IS), respectively.
11p vijiraiya2711 27-05-2020 16 1 Download