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Osteoblastic bone reaction
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Osteoblastic bone reaction (OBR) refers to an increase in bone density at the site of bone metastasis or the appearance of new sclerotic bone lesions after anticancer treatment. OBR can be misunderstood as disease progression. In this study, we aimed to investigate the prevalence and details of OBR and its association with clinical outcomes in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) treated with osimertinib.
9p
vioracle
29-09-2023
3
2
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Bone scintigraphy with 99mTc-labeled diphosphonates can identify prostate cancer bone metastases with high sensitivity, but relatively low specificity, because benign conditions such as osteoarthritis can also trigger osteoblastic reactions.
7p
vivermont2711
28-01-2021
6
1
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Fish has been recently recognized as a suitable vertebrate model and repre-sents a promising alternative to mammals for studying mechanisms of tis-sue mineralization and unravelling specific questions related to vertebrate bone formation. The recently developedSparus aurata(gilthead seabream) osteoblast-like cell line VSa16 was used to construct a cDNA subtractive library aimed at the identification of genes associated with fish tissue min-eralization.
12p
media19
04-03-2013
30
1
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To better understand the role of neuropeptide Y (NPY) in bone homeosta-sis, as its function in the regulation of bone mass is unclear, we assessed its expression in this tissue. By immunohistochemistry, we demonstrated, both at embryonic stages and in the adult, that NPY is synthesized by osteoblasts, osteocytes, and chondrocytes.
13p
mobifone23
18-01-2013
39
3
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