Ovarian cancer

Early prediction of ovarian cancer has not been given much attention, the application of combined models in clinical practice is not widespread, and the calculation of these models is still difficult due to the complexity and multiple variables.

8p viengfa 23-10-2024 6 1   Download

Platinum-based doublet chemotherapy is still supposed as standard regimen in ovarian cancer. However, the rate of relapse or refractory is also very high and vary from 80-85% with stage IIIIV ovarian cancer. The prognosis of platinum-resistant ovarian cancer (relapse or refractory within 6 months after initial treatment) has a median survival of 9–12 months and less than 15% respond to subsequent chemotherapy.

4p visarada 28-03-2025 3 0   Download

A retrospective study of 61 patients was conducted to evaluate the preliminary results of maximal cytoreductive surgery following neoadjuvant chemotherapy for FIGO stage IIIC-IV ovarian cancer from 2019 to 2023.

8p viyamanaka 06-02-2025 3 2   Download

Early prediction of ovarian cancer has not been given much attention, the application of combined models in clinical practice is not widespread, and the calculation of these models is still difficult due to the complexity and multiple variables.

8p viharuno 03-01-2025 3 2   Download

The aim of the thesis: Conducted with 2 objectives: Understanding the correlation between tumor markers CA125 and HE4 in ovarian cancer diagnosis; evaluation of the role of tumor markers CA125 and HE4 in monitoring and treating ovarian cancer. Mời các bạn cùng tham khảo nội dung chi tiết.

28p badbuddy07 26-02-2022 19 3   Download

Regulators of G protein signaling (RGS) proteins modulate G protein-coupled receptor (GPCR) signaling networks by terminating signals produced by active Gα subunits. RGS17, a member of the RZ subfamily of RGS proteins, is typically only expressed in appreciable amounts in the human central nervous system, but previous works have shown that RGS17 expression is selectively upregulated in a number of malignancies, including lung, breast, prostate, and hepatocellular carcinoma.

10p caothientrangnguyen 09-05-2020 14 1   Download

NBR1(named as next toBRCA1) was originally cloned as a candidate gene for the ovarian cancer antigen CA125, using expression cloning with the anti-CA125 Ig, OC125.NBR1 has been of interest due to its position close toBRCA1, although no involvement in breast or ovarian cancer has been demonstrated. Recently, the antigen CA125 has been cloned, and identi®ed as a new mucin, MUC16, entirely di€erent from NBR1.

8p research12 23-04-2013 48 3   Download

In birds, the egg envelope surrounding the oocyte prior to ovulation is called the perivitelline membrane and it plays important roles in fertiliza-tion. In a previous study we demonstrated that one of the components of the perivitelline membrane, ZP3, which is secreted from the ovarian granu-losa cells, specifically interacts with ZP1, another constituent that is synthe-sized in the liver of Japanese quail.

10p galaxyss3 07-03-2013 48 4   Download

The hypothalamic decapeptide gonadotropin-releasing hormone (GnRH) is well known for its role in the control of pituitary gonadotropin secretion, but the hormone and receptor are also expressed in extrapituitary tissues and tumor cells, including epithelial ovarian cancers.

16p vinaphone15 28-02-2013 31 3   Download

MicroRNAs are emerging as important regulators of cancer-related pro-cesses. Our studies show that microRNA-9 (miR-9) is downregulated in human ovarian cancer relative to normal ovary, and overexpression of miR-9 suppresses cell growthin vitro. Furthermore, the 3¢-UTR of NF-jB1 mRNA is found to be regulated directly by miR-9, demonstrating that NF-jB1 is a functionally important target of miR-9 in ovarian cancer cells.

10p viettel02 20-02-2013 22 3   Download

The standard chemotherapy for epithelial ovarian cancer (EOC) patients is currently a combination of taxane and platinum. However, most EOC patients still suffer relapses, and there is an immediate need for the devel-opment of novel and more effective therapeutic modalities against this deadly disease.

15p viettel02 19-02-2013 40 4   Download

Mutations in the tumor suppressor breast cancer susceptibility gene 1 (BRCA1), an important player in the DNA damage response, apoptosis, cell cycle regulation and transcription, confer a significantly elevated life-time risk for breast and ovarian cancer.

11p viettel02 19-02-2013 55 2   Download

The protein annexin IV (ANX4) is elevated specifically and characteristi-cally in ovarian clear cell adenocarcinoma (CCA), a highly malignant histo-logical subtype of epithelial ovarian cancer. On the basis of the hypothesis that the expression of ANX4in CCA is regulated by a unique transcription mechanism, we explored thecis-elements involved in CCA-specific ANX4 expression using a luciferase reporter.

14p cosis54 05-01-2013 39 4   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Gene Expression and Pathway Analysis of Ovarian Cancer Cells Selected for Resistance to Cisplatin, Paclitaxel, or Doxorubicin

28p sting01 15-01-2012 64 7   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Role of CA125 in predicting ovarian cancer survival - a review of the epidemiological literature

20p sting01 15-01-2012 41 4   Download

Jonsson et al. Journal of Translational Medicine 2011, 9:114 http://www.translational-medicine.

9p dauphong6 05-01-2012 52 5   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Development of targeted therapy for ovarian cancer mediated by a plasmid expressing diphtheria toxin under the control of H19 regulatory sequences

11p dauphong3 03-01-2012 51 4   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells

9p dauphong3 03-01-2012 51 6   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : The chemiluminescence based Ziplex® automated workstation focus array reproduces ovarian cancer Affymetrix GeneChip® expression profiles

14p dauphong3 03-01-2012 40 4   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Identifying alemtuzumab as an anti-myeloid cell antiangiogenic therapy for the treatment of ovarian cancer

14p dauphong3 03-01-2012 57 7   Download