Ovarian function suppression
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Ovarian cancer (OC) is a life-threatening gynecological malignancy where dysregulation of microRNAs (miRNAs) is frequently implicated. This study focuses on the function of miR-545 on OC development and the molecules involved.
16p vianrose2711 27-04-2021 11 2 Download
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Ovarian function suppression (OFS) has been shown to be effective as adjuvant endocrine therapy in premenopausal women with hormone receptor-positive breast cancer. However, it is currently unclear if addition of OFS to standard tamoxifen therapy after completion of adjuvant chemotherapy results in a survival benefit.
7p vinaypyidaw2711 26-08-2020 12 2 Download
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Aberrant Hedgehog (Hh) signaling is associated with the development of many cancers including prostate cancer, gastrointestinal cancer, lung cancer, pancreatic cancer, ovarian cancer, and basal cell carcinoma. The Hh signaling pathway has been one of the most intensely investigated targets for cancer therapy, and a number of compounds inhibiting Hh signaling are being tested clinically for treating many cancers.
10p vinaypyidaw2711 26-08-2020 8 1 Download
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ACFP is an anti-cancer fusion peptide derived from bovine milk protein. This study was to investigate the anti-cancer function and underlying mechanisms of ACFP in ovarian cancer. Our results suggest that ACFP may represent a potential therapeutic agent for ovarian cancer that functions by altering the expression and signaling of cancer-related pathways in ovarian cancer cells.
14p vinaypyidaw2711 26-08-2020 6 2 Download
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Several trials evaluated the role of ovarian function suppression for the adjuvant treatment of premenopausal patients with hormone receptor-positive early breast cancer.
11p vimanila2711 25-06-2020 11 1 Download
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Metritis and endometritis are the very common postpartum uterine infections that results into infertility in dairy cattle, production loss and economical losses to the farmer. As postpartum uterus favors bacterial growth so it is frequently found in almost of unhygienic environment reared animals. Breaching of birth canal during dystocia, retention of placenta, wet environment during winter season and immunosuppression due to many reasons are the risk factors for the bacteria invasion to uterus.
19p quenchua2 16-12-2019 15 2 Download
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MicroRNAs are emerging as important regulators of cancer-related pro-cesses. Our studies show that microRNA-9 (miR-9) is downregulated in human ovarian cancer relative to normal ovary, and overexpression of miR-9 suppresses cell growthin vitro. Furthermore, the 3¢-UTR of NF-jB1 mRNA is found to be regulated directly by miR-9, demonstrating that NF-jB1 is a functionally important target of miR-9 in ovarian cancer cells.
10p viettel02 20-02-2013 20 2 Download