P53 signaling
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YAP and TAZ, the Hippo pathway terminal transcriptional activators, are frequently upregulated in cancers. In tumor cells, they have been mainly associated with increased tumorigenesis controlling different aspects from cell cycle regulation, stemness, or resistance to chemotherapies.
18p vishanshan 27-06-2024 1 1 Download
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Cyclin B2 (CCNB2), a member of the cyclin family, is an oncogene in multiple cancers, including nasopharyngeal carcinoma (NPC). However, the epigenetics mechanism for CCNB2 overexpression in NPC remains unclear. This study dissects the regulatory role of CCNB2 in NPC and the molecular mechanism.
14p vishanshan 27-06-2024 2 1 Download
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Ebook "The hippo signaling pathway and cancer" is rapidly gaining recognition as an important player in organ size control and tumorigenesis, and many leading scientists are showing increased interest in this growing field and it's relation to cancer. The chapters in this volume cover virtually all aspects of tumor biology, because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Ras, Wnt, TGFbeta and p53.
344p manmanthanhla0201 27-02-2024 7 1 Download
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S100A1 expression is deregulated in a variety of human malignancies, but its role in normal and malignant endometrial cells is unclear. Methods: We used endometrial carcinoma (Em Ca) cell lines to evaluate the physical and functional interaction of S100A1 with p53 and its negative regulator, mouse double minute 2 (MDM2).
13p vipriyankagandhi 27-07-2022 3 1 Download
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As CRISPR/Cas9 mediated screens with pooled guide libraries in somatic cells become increasingly established, an unmet need for rapid and accurate companion informatics tools has emerged. We have developed a lightweight and efficient software to easily manipulate large raw next generation sequencing datasets derived from such screens into informative relational context with graphical support.
13p vilarryellison 29-10-2021 2 1 Download
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Optimizing the safety and efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is of clinical relevance. Serum starvation in vitro and short-term food starvation in vivo both stress cells by the sudden depletion of paracrine growth stimulation.
10p vijisoo2711 30-09-2020 5 2 Download
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We investigated the role of the HIPK2–p53 signaling pathway in tumorigenesis and resistance to the drug Verbascoside (VB) in colorectal cancer (CRC), using in vivo and in vitro experiments. Methods: Primary human CRC samples and normal intestinal tissues from patients were analyzed for HIPK2 expression by immunohistochemistry (IHC) and its expression was correlated against patients’ clinicopathological characteristics.
11p vilisa271 22-09-2020 17 1 Download
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Breast cancer causes the No.1 women cancer prevalence and the No.2 women cancer mortality worldwide. Nuclear receptor/transcriptional factor signaling is aberrant and plays important roles in breast cancer pathogenesis and evolution, such as estrogen receptor α (ERα/ESR1), tumor protein p53 (p53/TP53) and Nuclear factor kappa B (NFκB).
8p vimale2711 25-08-2020 13 1 Download
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CAPON has two isoforms in human brain: long form of CAPON (CAPON-L) and short form of CAPON (CAPON-S). Recent studies have indicated the involvement of CAPON in tumor cell growth. We aimed to reveal the role of the two CAPON isoforms in the proliferation of glioma cells in this study.
9p vinasaki2711 12-11-2019 10 2 Download
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Elimination of reactive oxygen species (ROS) can be an important strategy to improve healing of wounds. ROS have an effect on proliferation and cell survival signaling, which results in alteration of apoptotic pathways in cells. Melatonin has antioxidant properties on skin wounds.
8p vikimsa 22-02-2019 14 0 Download
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Small molecules that activate the transcriptional function of wild type p53 have proved active as anti-cancer drugs in preclinical models and are now entering clinical trial. The complexity of the upstream p53 signaling pathway offers many targets for the devel-opment of such activators and the action of Mdm2 inhibitors, kinase inhibitors, sirtuin inhibitors and low doses of actinomycin D will be described among other examples.
3p viettel02 22-02-2013 39 2 Download
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Genomic stability is constantly threatened by DNA damage, caused by numerous environmental and intrinsic sources, including radiation, chemi-cals and oncogene expression. Consequently, cells have evolved a sophisti-cated signal transduction network to sense DNA damage and to mount an appropriate DNA damage response.
10p viettel02 20-02-2013 29 1 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Systems biology-defined NF-κB regulons, interacting signal pathways and networks are implicated in the malignant phenotype of head and neck cancer cell lines differing in p53 status...
22p coxanh_8 05-11-2011 46 3 Download
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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Genome-wide identification of novel expression signatures reveal distinct patterns and prevalence of binding motifs for p53, nuclear factor-κB and other signal transcription factors in head and neck squamous cell carcinoma...
25p thulanh19 05-11-2011 44 3 Download
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Practical TCP/IP and Ethernet Networking- P53: The transmitter encodes the information into a suitable form to be transmitted over the communications channel. The communications channel moves this signal as electromagnetic energy from the source to one or more destination receivers. The channel may convert this energy from one form to another, such as electrical to optical signals, whilst maintaining the integrity of the information so the recipient can understand the message sent by the transmitter....
5p jupyter2468 26-10-2010 44 2 Download
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Digital images and video, acquired by still cameras, consumer camcorders, or even broadcast-quality video cameras, are usually degraded by some amount of blur and noise. In addition, most electronic camerashavelimitedspatial resolutiondeterminedbythecharacteristicsof thesensorarray. Common causes of blur are out-of-focus, relative motion, and atmospheric turbulence. Noise sources include filmgrain, thermal, electronic, and quantization noise.
21p longmontran 18-01-2010 79 7 Download