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PAK1 kinase
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P21-activated protein kinase 1 (PAK1), a main downstream effector of small Rho GTPases, is overexpressed in many malignancies. PAK1 overexpression is associated with poor prognosis in some tumor types, including breast cancer, gastric cancer, and colorectal cancer.
7p
vilisa271
22-09-2020
14
1
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Key effector(s) of mutated KRAS in lung cancer progression and metastasis are unknown. Here we investigated the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC).
12p
vialabama2711
21-09-2020
8
0
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Pancreatic ductal adenocarcinoma remains one of the most lethal of all solid tumours. Treatment options are limited and gemcitabine-based chemotherapy remains the standard of care. Although growing evidence shows that p21-activated kinase 1 (PAK1) plays a crucial role in pancreatic cancer, its role has not been fully elucidated.
12p
vinaypyidaw2711
26-08-2020
11
1
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P21-activated kinase 1 (PAK1) stimulates growth and metastasis of colorectal cancer (CRC) through activation of multiple signalling pathways. Up-regulation of CRC stem cell markers by PAK1 also contributes to the resistance of CRC to 5-fluorouracil.
9p
vidhaka2711
31-07-2020
7
1
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Lysophosphatidicacid (LPA), oneof thenaturallyoccurring phospholipids, stimulates cellmotility through theactivation of Rho family members, but the signaling mechanisms remain tobe elucidated. In thepresent study,we investigated the roles of p21-activated kinase 1 (PAK1) onLPA-induced focal adhesion kinase (FAK) phosphorylation and cell motility.
9p
dell39
03-04-2013
33
2
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