Pancreatic cancer

Pancreatic diseases is very multiform and complex, in which pancreatic tumors have often poor prognosis, especially pancreatic cancer. Early detection and diagnosis of pancreatic tumors have great significance in improving the quality of treatment and prognosis for patients. Endoscopic ultrasound has the advantage of high-frequency ultrasound, an optimal approach to provide a possibility of EUS-FNA.

7p vifaye 20-09-2024 2 1   Download

Laparoscopic left lateral sectionectomy (LLLS) is indicated for liver tumors which locate in easily accessible locations (left lateral section, left lobe, ...), with small sizes,... Feasibility, safety also depend on surgeon skills, equipments. Objectives: Evaluate short-term outcomes of LLLS to treat hepatocellular carcinoma.

5p vinatisu 29-08-2024 2 1   Download

Pancreaticobiliary maljunction (PBM) is a rare congenital anomaly and possess potential risk of cancer. Aims: To present of a case of acute pancreatitis associated with PBM and review the literature.

5p vinatisu 29-08-2024 3 1   Download

The association between body mass index (BMI) and the overall survival (OS) of pancreatic ductal adenocarcinoma (PDAC) patients remains controversial and unclear, Method: A total of 2010 patients from a high-volume center were enrolled in the study. The OS of PDAC patients was evaluated based on restricted cubic spline (RCS), propensity score (PS) and multivariable risk adjustment analyses.

11p vielonmusk 21-01-2022 10 1   Download

The prognosis of pancreatic cancer (PC) has been improved by new chemotherapy regimens (combination of 5-fuorouracil, oxaliplatin, irinotecan, and leucovorin (FOLFIRINOX) or gemcitabine plus nab-paclitaxel (GnP)). Unfortunately, chemotherapy-induced peripheral neuropathy (CIPN) is a common adverse event of these two regimens. The efficacy of pregabalin for CIPN has been reported in previous studies.

7p vielonmusk 21-01-2022 14 2   Download

No reliable nomogram has been developed until date for predicting the survival in patients with unresectable pancreatic cancer undergoing treatment with gemcitabine plus nab–paclitaxel (GnP) or FOLFIRINOX. Methods: This analysis was conducted using clinical data of Japanese patients with unresectable pancreatic cancer undergoing GnP or FOLFIRINOX treatment obtained from a multicenter study (NAPOLEON study).

11p vielonmusk 21-01-2022 15 1   Download

Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies, is increasing in incidence. However, the stromal reaction pathophysiology and its role in PDAC development remain unknown. We, therefore, investigated the potential role of histological chronic pancreatitis findings and chronic inflammation on surgical PDAC specimens and disease-specific survival (DSS).

12p vielonmusk 21-01-2022 14 1   Download

To gain better insight into the insulin secretory activity of fetalbcells in response to glucose, the expression of glucose transporter 2 (GLUT-2), glucokinase and mitochondrial glycerol phosphate dehydrogenase (mGDH) were studied. Expression ofGLUT-2mRNA and protein in pancreatic islets and liver was signi®cantly lower in fetal and suckling rats than in adult rats.

9p research12 29-04-2013 47 4   Download

We purified pancreatic deoxyribonucleases I (DNases I) from three snakes, Elaphe quadrivirgata, Elaphe climaco-phoraandAgkistrodon blomhoffii, and cloned their cDNAs. Each mature snake DNase I protein comprised 262 amino acids. Wild-type snake DNases I with Leu130 were more thermally unstable than wild-type mammalian and avian DNases I with Ile130. After substitution of Leu130Ile, the thermal stabilities of the snake enzymes were higher than those of their wild-type counterparts and similar to mam-malian wild-type enzyme levels....

8p tumor12 20-04-2013 41 3   Download

Humanpancreatic secretions contain twomajor trypsinogen isoforms, cationic and anionic trypsinogen, normally at a ratio of 2 : 1. Pancreatitis, pancreatic cancer and chronic alcoholism lead to a characteristic reversal of the isoform ratio, and anionic trypsinogen becomes the predominant zymogen secreted. To understand the biochemical conse-quences of these alterations, we recombinantly expressed and purified both human trypsinogens and documented characteristics of autoactivation, autocatalytic degradation and Ca 2+ -dependence....

12p fptmusic 16-04-2013 40 3   Download

Human amylin (hA) is a small fibrillogenic protein that is the major con-stituent of pancreatic islet amyloid, which occurs in most subjects with type-2 diabetes mellitus (T2Dm). There is growing evidence that hA toxic-ity towards islet b-cells is responsible for their gradual loss of function in T2Dm. Preventing hA-mediated cytotoxicity has been proposed as a route to halt the progression of this disease, although this has not yet been dem-onstratedin vivo.

11p fptmusic 12-04-2013 30 1   Download

Chromosomal rearrangements apparently account for the presence of a pri-mate-specific gene (protease serine 3) in chromosome 9. This gene encodes, as the result of alternative splicing, both mesotrypsinogen and trypsino-gen 4. Whereas mesotrypsinogen is known to be a pancreatic protease, neither the chemical nature nor biological function of trypsinogen 4 has been explored previously.

11p galaxyss3 21-03-2013 41 3   Download

Trypsinogen-1 and -2 are well-characterized enzymes that are expressed in the pancreas and also in several other tissues. Many cancers produce tryp-sinogen isoenzymes that differ from the pancreatic ones with respect to substrate specificity and isoelectric point.

13p media19 05-03-2013 26 2   Download

Traditionally, the canine pancreatic endoplasmic reticulum (ER) has been the workhorse for cell-free studies on protein transport into the mamma-lian ER. These studies have revealed multiple roles for the major ER-lumi-nal heat shock protein (Hsp) 70, IgG heavy chain-binding protein (BiP), at least one of which also involves the second ER-luminal Hsp70, glucose-reg-ulated protein (Grp) 170.

13p media19 04-03-2013 30 3   Download

Neither randomized clinical trials nor meta- analysis are available and evidence is based on a number of retrospective studies with multivariate for mortality risk factors or data from national cancer registries (Gilliland et al., 1997; Hundahl et al., 1998). Unfortunately, very remarkable differences in patient’s selection, staging systems, and clinical management affect the available studies. In particular, radioiodine treatment is not routinely carried out in a standard manner and outcome results of different studies are thus not comparable (Sciuto et al., 2009).

180p wqwqwqwqwq 20-07-2012 83 6   Download

A person who had the cancer and died 10 years later of the cancer would contribute an event, a death due to the cancer, having also contributed 10 person-years of survival time. A 90 % cancer specific survival at 10 years would mean that 90 % of patients had not died from their cancer, while 10 % had died from their cancer (Kaplan, 1958). Calculation of cause-specific survival is especially important when studying diseases with a favorable prognosis, as is the case at hand, where the patients live long enough to be exposed to other causes of death....

524p wqwqwqwqwq 20-07-2012 322 8   Download

Cause-specific survival is commonly estimated in cancer clinical trials and only those deaths which can be attributed to the cancer in question are considered to be events, while all other deaths are considered censorings. Using cause-specific survival to estimate net survival requires that reliably coded information on cause of death is available. The distinguishing feature of survival analysis is that at the end of the follow-up period the event (such as death due to cancer) will probably not have occurred for all patients.

226p wqwqwqwqwq 20-07-2012 83 5   Download

Accurate statistics on cancer occurrence and outcome are essential both for the purposes of research and for planning and evaluation programmes for cancer control (Parkin, 2006). Although tumours of thyroid account for only 1% of the overall human cancer burden, they represent the most common malignancies of the endocrine system and pose a significant challenge to pathologists, surgeons and endocrinologists. Among epithelial tumors, carcinomas of follicular cell origin far outnumber those of C-cell origin.

444p wqwqwqwqwq 20-07-2012 78 8   Download

Pancreatic cancer is one of the most fatal human malignancies with extremely poor prognosis making it the fourth leading cause of cancer-related deaths in the United States. The molecular mechanisms of pancreatic carcinogenesis are not well understood. The major focus of these two books is towards the understanding of the basic biology of pancreatic carcinogenesis, identification of newer molecular targets and the development of adjuvant and neoadjuvant therapies.

324p wqwqwqwqwq 20-07-2012 136 10   Download

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Identification of a biomarker panel using a multiplex proximity ligation assay improves accuracy of pancreatic cancer diagnosis

12p dauphong3 03-01-2012 39 4   Download