Pancreatic neuroendocrine tumors

The goal of this study was to evaluate efficacy and safety of 90Y radioembolization for neuroendocrine liver metastases (NELM) in a multicenter registry. Toxicities were reported using Common Terminology Criteria for Adverse Events v.5. Cox Proportional Hazards were calculated for pancreatic primary, performance status, extrahepatic disease at treatment, unilobar treatment, baseline ascites, and>25% tumor burden.

11p vikolindagrabar 27-07-2022 4 1   Download

Cytotoxic chemotherapy combinations and targeted agents represent established treatment concepts in advanced pancreatic neuroendocrine tumors (PNETs). However, response rates, side effects and outcome data strongly vary among these therapeutic approaches.

9p vimahuateng 26-11-2021 2 0   Download

Recent studies have suggested the important roles of CD47 and tumor-associated macrophages in the prognosis and immunotherapy of various human malignancies. However, the clinical significance of CD47 expression and CD163+ TAMs in pancreatic neuroendocrine tumor (PanNET) remains unclear.

9p vianrose2711 27-04-2021 6 1   Download

Pancreatic neuroendocrine tumors (pNETs) are a heterogeneous group of neoplasms with malignant behaviors that can develop from inert slow growth or low malignancy to aggressive metastasis during follow-up.

10p vianrose2711 27-04-2021 7 1   Download

We assessed the activity and toxicity of the XELBEVOCT regimen in patients with metastatic well-to-moderately differentiated neuroendocrine neoplasms (WMD-NEN). Ancillary studies evaluated hypertension, proteinuria, and vascular endothelial growth factor (VEGF) polymorphisms in predicting progression-free survival (PFS) and the predictive role of serum vitamin D in progression-free survival and proteinuria onset.

10p virose2711 25-09-2020 9 0   Download

Pancreatic neuroendocrine neoplasms (p-NENs) are a group of highly heterogeneous tumors with distinct clinicopathological features and long-term prognosis. In 2017, in order to better stratify patients into prognostic groups and predicting their outcomes, World Health Organization (WHO) officially updated its grading system for p-NENs which distinguished these neoplasms among Grading 1 (G1) pancreatic neuroendocrine tumors (p-NETs), G2 p-NETs, G3 p-NETs and G3 pancreatic neuroendocrine carcinomas (p-NECs).

11p virose2711 25-09-2020 12 0   Download

Gangliocytic paraganglioma (GP) is an extremely rare benign tumor that commonly arises from the second part of the duodenum. Since GP exhibit neither prominent mitotic activity nor Ki-67 immunoreactivity, this tumor is often misdiagnosed as neuroendocrine tumor (NET) G1 (carcinoid tumor).

9p vialabama2711 21-09-2020 15 1   Download

Mammalian target of rapamycin (mTOR) inhibitors have anti-tumor effects against renal cell carcinoma, pancreatic neuroendocrine cancer and breast cancer. In this study, we analyzed the antitumor effects of mTOR inhibitors in small cell lung cancer (SCLC) cells and sought to clarify the mechanism of resistance to mTOR inhibitors.

8p vialabama2711 21-09-2020 6 0   Download

Paraneoplastic neurological syndrome (PNS) is a heterogeneous group of disorders affecting any part of the nervous system, in a patient affected by cancer. PNS is estimated to occur in 0.01 to 8 % of cancer patients, with higher incidence in those with small cell lung cancer, gynecological tumours or hematological disease.

4p vimoscow2711 29-08-2020 10 0   Download

Streptozocin (STZ) based chemotherapy is recommended for patients with metastatic pancreatic neuroendocrine tumors (pNET). Temozolomide as mono- or combination therapy has been suggested to be a promising alternative. However, the treatment is costly and not approved for the treatment of pNETs.

7p vimale2711 25-08-2020 8 0   Download

Lanreotide depot/autogel antitumor activity in intestinal/pancreatic neuroendocrine tumors (NETs) was demonstrated in the phase-3 CLARINET study (NCT00353496), based on significantly prolonged progressionfree survival (PFS) versus placebo.

9p viputrajaya2711 22-06-2020 5 0   Download

The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) staging classifications are two broadly used systems for pancreatic neuroendocrine tumors.

8p vijakarta2711 09-06-2020 6 0   Download

Li-Fraumeni syndrome is a cancer predisposition syndrome caused by germline TP53 tumor suppressor gene mutations, with no previous association with pancreatic neuroendocrine tumors (PNETs). Here we present the first case of PNET associated with Li-Fraumeni syndrome.

6p vijakarta2711 09-06-2020 16 2   Download

To present a case of recurrent hypoglycemia following Roux-en-Y gastric bypass (RYGB) surgery whose etiology was determined to be a proinsulin-predominant pancreatic neuroendocrine tumor (a proinsulinoma).

5p caothientrangnguyen 09-05-2020 12 1   Download

Over many years, the petrochemical industry has built up an effective infra- structure for processing and distributing hydrocarbon-based products. Due to reliance on imported crude oil, much of the U.S. infrastructure is geographically located around the coastline (Fig. 9). Thus, many current processing facilities are not well situated for the collection of large volumes of plant-derived material. Where plant materials are processed in lumber mills, oil crushers, or corn wet mills, these are situated adjacent to areas of supply.

20p loixinloi 08-05-2013 62 4   Download

When someone arrives at a web site, you have a limited amount of attention available. How much time that equates to is unknown. It depends on the competition, visitor's expectations, and how badly they need what your site offers. And when you only have a limited amount of attention, there is a limit to the number of signals you can convey. So aim to make every signal relevant, significant, and helpful . The more efficiently you can communicate what you have to get across, the more likely you are to keep your visitor's attention, and the greater your success.

6p seketnoi 29-04-2013 110 7   Download

According to financial aid officials at 2-year and less-than-2-year schools we visited, prior to the Direct Loan Program, some FFELP lenders refused to lend to students at their schools because some of their graduates did not repay their loans on time. In contrast, financial aid officials at public and private 4-year schools we visited said that they did not have any problems finding lenders to serve their students, and FFELP lenders actively marketed their products to them and their students....

105p dacotaikhoan 26-04-2013 32 2   Download

So long as there is no international government; so long as there is anarchy between states; so long can there be no permanent local, municipal, domestic law in one state either. Just as there are frontieres sans medicins, so politics has few real frontiers. Many non- governmental organisations are financed by other countries’ governments for governmental purposes, not all of them benign. Things fall apart. Unannounced, and confused with the ordinary, war will fly in a window on a lazy September day. From confusion to fusion: the next nine-eleven will be nuclear, of course.

11p hoangphiyeah1tv 18-04-2013 44 4   Download

The algorithms for all the relational operators are written as if they were to be run on a single processor. As shown in Figure 3, the input to an Operator Process is a stream of tuples and the output is a stream of tuples that is demultiplexed through a structure we term a split table. Once the process begins execution, it continuously reads tuples from its input stream, operates on each tuple, and uses a split table to route the resulting tuple to the process indicated in the split table. 4 When the process detects the end of its input stream, it first closes the output...

165p nhacsihuytuan 13-04-2013 35 2   Download

A horizon is perspectival. There are no horizons without perceivers. One sense of the word 'environment' has that logic, noticing the modifiers. My environment is rather like my horizon. I take it with me as I move through the world. Horizons require an attention span. Analogously, my environment has an owner. We can spell this 'environment' with a lower case e. Arnold Berleant concludes: 'This is what environment means: a fusion of organic awareness, of meanings both conscious and unaware, of geographical location, of physical presence, personal time, pervasive movement. . .

9p giamdocamnhac 06-04-2013 46 2   Download