Particle clearance

Silica and asbestos are recognized lung carcinogens. However, their role in carcinogenesis at other organs is less clear. Clearance of inhaled silica particles and asbestos fibers from the lungs may lead to translocation to sites such as the bladder where they may initiate carcinogenesis.

13p vijakarta2711 09-06-2020 34 0   Download

Macrophages are equipped with several receptors for the recognition of foreign particles and pathogens. Upon binding to these receptors, particles become internalized. An interaction of particles with macrophage surface receptors is accompanied by an increase in cytosolic calcium concentration.

11p vienzym2711 03-04-2020 8 1   Download

The behavior of bioaerosol particles with various size and shape in the human respiratory tract was simulated by using a probabilistic model of the lung and an almost realistic mathematical approach to particle deposition. Results obtained from the theoretical computations clearly show that biogenic particle deposition in different lung compartments does not only depend on physical particle properties, but also on breathing mode (nose or mouth breathing) and inhalative flow rate (=tidal volume • breathing frequency/30).

10p kethamoi1 17-11-2019 14 0   Download

The thought of mucus disturbs many people. Mucus is beneficial as the first defense of the airways. The mucus lining traps inhaled particles and allows them to be cleared from the airway by cilia and cough. The mucus layer also prevents dehydration and desiccation of the airway surface and provides a nutrient milieu for the ciliated epithelium. Mucus can also be quite bad. Airway mucus retention due to hypersecretion or poor mucus clearance is a characteristic of many airway diseases including cystic fibrosis, chronic bronchitis, bronchiectasis, and asthma.

291p crius75 03-01-2013 37 3   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài: " Mucociliary and long-term particle clearance in airways of patients with immotile cilia...

8p toshiba13 21-10-2011 47 4   Download