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Pathogenic mechanisms underlying
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Liver Hepatocellular carcinoma (LIHC) exhibits a high incidence of liver cancer with escalating mortality rates over time. Despite this, the underlying pathogenic mechanism of LIHC remains poorly understood.
19p
vikoch
27-06-2024
1
1
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Iron is a crucial element for bacterial survival and virulence. During Salmonella infection, the host utilizes a variety of mechanisms to starve the pathogen from iron. However, Salmonella activates distinctive defense mechanisms to acquire iron and survive in iron-restricted host environments.
14p
vihagrid
30-01-2023
7
3
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Bacterial infections are common in postpartum dairy cows. Cortisol level has been observed to increase in dairy cows during peripartum period, and is associated with the endometrial innate immunity against pathogens like E.coli. However, the mechanism underlying how cortisol regulates E.coli-induced inflammatory response in bovine endometrial epithelial cells (BEEC) remains elusive.
8p
vigalileogalilei
28-02-2022
20
1
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Heterobasidion parviporum is an economically most important fungal forest pathogen in northern Europe, causing root and butt rot disease of Norway spruce (Picea abies (L.) Karst.). The mechanisms underlying the pathogenesis and virulence of this species remain elusive. No reference genome to facilitate functional analysis is available for this species.
21p
vibeauty
23-10-2021
6
1
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Fusarium circinatum is a pressing threat to the cultivation of many economically important pine tree species. Efforts to develop effective disease management strategies can be aided by investigating the molecular mechanisms involved in the host-pathogen interaction between F. circinatum and pine species. Pinus tecunumanii and Pinus patula are two closely related tropical pine species that differ widely in their resistance to F.
13p
vitzuyu2711
29-09-2021
14
1
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A genome-scale metabolic model of potato late blight suggests a photosynthesis suppression mechanism
Phytophthora infestans is a plant pathogen that causes an important plant disease known as late blight in potato plants (Solanum tuberosum) and several other solanaceous hosts. This disease is the main factor affecting potato crop production worldwide. In spite of the importance of the disease, the molecular mechanisms underlying the compatibility between the pathogen and its hosts are still unknown.
14p
viseulgi2711
31-08-2021
23
1
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Under caged conditions, birds are affected more severely by environmental stressors such as dietary structure, activity space, human disturbances, and pathogens, which may be reflected in the gene expression in peripheral blood or other tissues. Elucidating the molecular mechanism of these stress responses will help improve animal welfare.
13p
visilicon2711
20-08-2021
7
1
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Penicillium italicum (blue mold) is one of citrus pathogens causing undesirable citrus fruit decay even at strictly-controlled low temperatures (< 10 °C) during shipping and storage. P. italicum isolates with considerably high resistance to sterol demethylation inhibitor (DMI) fungicides have emerged; however, mechanism(s) underlying such DMI-resistance remains unclear.
16p
vijeeni2711
24-07-2021
6
0
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Age-related resistance (ARR) is a developmentally regulated phenomenon conferring resistance to pathogens or pests. Although ARR has been observed in several host-pathogen systems, the underlying mechanisms are largely uncharacterized. In cucumber, rapidly growing fruit are highly susceptible to Phytophthora capsici but become resistant as they complete exponential growth.
25p
vijeeni2711
30-06-2021
8
1
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Gastrodia elata Bl. f. glauca S. Chow is a medicinal plant. G. elata f. glauca is unavoidably infected by pathogens in their growth process. In previous work, we have successfully isolated and identified Penicillium oxalicum from fungal diseased tubers of G. elata f. glauca.
17p
vijichea2711
28-05-2021
6
1
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Aging is a known risk factor of idiopathic pulmonary fibrosis (IPF). However, the pathogenic mechanisms underlying the effects of advanced aging remain largely unknown. Telomeric repeat-containing RNA (TERRA) represents a type of long noncoding RNA.
15p
vimaine2711
26-03-2021
7
2
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This systematic review focusses on inflammation as an underlying pathogenic mechanism in sciatica. We addressed two questions in particular: (1) what inflammatory biomarkers have been identified in patients with sciatica in the literature so far? 2) is there an association between the level of inflammatory activity and clinical symptoms.
9p
vivermont2711
28-01-2021
7
2
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Identifying relatedness among diseases could help deepen understanding for the underlying pathogenic mechanisms of diseases, and facilitate drug repositioning projects. A number of methods for computing disease similarity had been developed; however, none of them were designed to utilize information of the entire protein interaction network, using instead only those interactions involving disease causing genes.
13p
vioklahoma2711
19-11-2020
15
2
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Motility in bacteria forms the basis for taxis and is in some pathogenic bacteria important for virulence. Video tracking of motile bacteria allows the monitoring of bacterial swimming behaviour and taxis on the level of individual cells, which is a prerequisite to study the underlying molecular mechanisms.
8p
vicolorado2711
22-10-2020
9
0
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Chromosome instability manifests as an abnormal chromosome complement and is a pathogenic event in cancer. Although a correlation between abnormal chromosome numbers and cancer exist, the underlying mechanisms that cause chromosome instability are poorly understood.
10p
vijennie2711
29-09-2020
19
0
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Paraneoplastic acral vascular syndrome (PAVS) is a rare phenomenon which is observed in patients with adenocarcinomas and other malignancies. Various potential pathogenic mechanisms such as tumour invasion of sympathetic nerves, hyperviscosity, hypercoagulability, vasoactive tumour-secreted substances, and immunological mechanisms have been suggested.
5p
vithimphu2711
31-07-2020
26
1
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Far infrared radiation (FIR) has been widely used to treat chronic diseases and symptoms; however, the underlying mechanism remains unclear. As gut microbiota (GM) markedly impact the host’s physiology, making GM a potential target for the therapeutic evaluation of FIR. C57BL/6J mice were exposed to five times of 2 min-FIR exposure on the abdomen, with a two-hour interval of each exposure within one day. Fecal samples were collected on day one and day 25 after the FIR/control treatment, and the extracted fecal DNAs were evaluated using ERIC-PCR and 16S amplicon sequencing.
8p
partimesinhvien
08-05-2020
6
0
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Increase in animal population has resulted in rise in animal bite cases and thus increase the potential for transmission of zoonotic diseases. That is why it is very important to consider some factors while considering the likelihood of disease transmission which includes species of animal, type of injury, severity of injury, vaccination status, interval between incident and treatment, and various attributes of the injured person (age, underlying health, etc.). It is also important to have knowledge about the natural oral flora of the animal.
17p
cothumenhmong3
22-02-2020
12
0
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Endophytes are the micro-organism which shares the life long relation with the host. The bacterial endophytes promote the growth directly and indirectly by several mechanisms. Keeping in mind, the present investigation has been carried out to evaluate the bacterial endophytes for their plant growth promotion in vitro condition. Four screened bacterial antagonists viz., SVC 11, BE 1, NGB 21 and M1W1 were evaluated for the germination and the vigour of French bean, brinjal and rapeseed mustard seeds. The bacteria were used individual as well as in consortium mode on the respective seeds.
9p
quenchua2
15-12-2019
23
0
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Endophytes are the organisms that live within plant tissues and spend at least a half of their life time without causing disease under any circumstances. So, the endophytes are commonly defined as those organisms whose infections are inconspicuous and symptomless in host tissue and internal microbial colonization. Both prokaryote (bacteria) and eukaryotes (fungi) colonize the plant tissues exhibiting a little variation in their colonization mode. The former colonize intracellularly in vascular tissues and the later shows asymptomatic colonization either inter or intracellularly.
12p
kethamoi2
15-12-2019
14
0
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