Pathogenicity study
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Breast cancer is a common cause for central nervous system (CNS) metastasis, resulting in a significant reduction in overall survival. Germline pathogenic variants (PVs) in BRCA1/2 are the most common genetic risk factor for breast cancer, associated with poor prognostic factors. This study sought to explore the patterns and outcome of CNS metastases in breast cancer patients with germline PVs in BRCA1/2 genes.
12p vikoch 27-06-2024 1 1 Download
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Myelodysplastic syndrome (MDS) is known to arise through the pathogenic bone marrow mesenchymal stem cells (MSC) by interacting with hematopoietic stem cells (HSC). However, due to the strong heterogeneity of MDS patients, it is difficult to find common targets in studies with limited sample sizes. This study aimed to describe sequential molecular changes and identify biomarkers in MSC of MDS transformation.
14p vikoch 27-06-2024 1 1 Download
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Antibiotic-resistant bacteria are increasingly common and threaten human health. Recently, antibiotic resistance in food associated bacteria become an emerging threat to this state. This study aimed to investigate the antibiotic resistance of seven Lactobacillus strains having potential application as probiotics, to common 14 antibiotics.
9p viamancio 04-06-2024 2 0 Download
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This study aimed to isolate and identify marine fungi from Bai Tu Long Bay and assess their antimicrobial potential. We successfully isolated twenty strains of marine-derived fungi. The crude extracts from these fungi were tested against pathogenic microorganisms. All twenty strains exhibit some degree of growth inhibition against the tested microorganisms.
9p dianmotminh02 03-05-2024 3 1 Download
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In this study, we conducted sequencing of the entire gene coding region (WES) in the patient and identified a compound heterozygote variants (c.289C>G, p.Arg97Gly and c.433C>T, p.Arg145Trp) in the TNNI3 gene. These variants were inherited from the patient's father and mother, who were heterozygous variant carriers. These variants were also identified as the pathogenic variants in the ClinVar database (accession number VCV001331910.2 and VCV000012426.28, respectively) and were the cause of the patient's disease.
12p dianmotminh02 03-05-2024 1 1 Download
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In recent times many research activities have been carried out to prove the metal ion detection ability of Schiff bases. [13,14] In the present study, a new Schiff base has been synthesized from 5-bromo-2- hydroxybenzaldehyde and naphthalene-1,8-diamine and it is complexated with Co(II), Ni(II), Cu(II) and Zn(II) ions. The biological application of all the compounds has been analyzed and metal ions recognition property of the Schiff base has also been studied.
16p dianmotminh02 03-05-2024 5 1 Download
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Cathelicidins include antimicrobial peptides (AMPs) and are involved in the innate immune defense against infections in mammals. Polymorphisms in the DNA sequence of cathelicidin genes could be relevant to inherited variations of host innate immunity, adaptation, and pathogen resistance. This study aims to investigate the sequence polymorphism of cathelicidin genes including CATHL2 and CATHL4 from local indigenous yellow cattle breeds of Vietnam.
11p dianmotminh02 03-05-2024 8 1 Download
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Ebook "Systems biology of tuberculosis" starts with a general introduction into the relevance of systems biology for understanding tuberculosis. This will be followed by several chapters which describe the application of systems biology to various aspects of the study of the pathogen, Mycobacterium tuberculosis, and its interaction with the host. The book provides the reader with an account of how the new science of systems biology is providing novel insights into the ancient scourge of tuberculosis.
238p ladongphongthanh1008 22-04-2024 3 2 Download
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The present study aims to identify Neofusicoccum isolates collected from lotus with symptoms of dieback, blight, and wilted leaves. Species were identified based on their morphology and comparison of the DNA sequence data for ITS rDNA and β-tubulin (tub-2). The taxonomy and phylogenetic relationships of pathogen isolates were investigated, and their pathogenic abilities were determined.
17p viritesh 02-04-2024 5 1 Download
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Study on the antagonistic activity against two pathogenic bacteria in humans (Staphylococcus aureus and Streptococcus pneumoniae) of the Streptomyces MIP_L26 (Called MIP_L26), isolated from the soil in the root zone of the May Chang tree; to investigate the biological characteristics of MIP_L26.
6p viohoyo 02-04-2024 3 2 Download
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This study aimed to evaluate the presence of aerobic bacteria and fungi in the oral and nasal cavities of Jrai healthy individuals in the Central Highland. Oral and nasal swab samples of 140 healthy Vietnamese were collected. Microbiological procedures were performed using standard techniques.
8p vioraclene 31-03-2024 4 2 Download
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In recent years, research has consistently proven the occurrence of genetic overlap across autoimmune diseases, which supports the existence of common pathogenic mechanisms in autoimmunity. The objective of this study was to further investigate this shared genetic component.
13p vibransone 28-03-2024 5 2 Download
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Prior research has established that the prevalence of pathogenic/likely pathogenic (P/LP) variants across all of the American College of Medical Genetics (ACMG) Secondary Findings (SF) genes is approximately 0.8–5%. We investigated the prevalence of P/LP variants in the 24 ACMG SF v2.0 cancer genes in a family-based cancer research cohort (n = 1173) and in cancer-free ethnicity-matched controls (n = 982).
9p vibransone 28-03-2024 3 2 Download
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Tuberculosis (TB) is a global infectious threat that is intensified by an increasing incidence of highly drug-resistant disease. Whole-genome sequencing (WGS) studies of Mycobacterium tuberculosis, the causative agent of TB, have greatly increased our understanding of this pathogen.
18p vibransone 28-03-2024 4 2 Download
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During aging, there is a physiological decline, an increase of morbidity and mortality, and a natural change in the gut microbiome. In this study, we investigated the influence of the gut microbiome on different metabolic parameters in adult and aged mice.
9p vibransone 28-03-2024 2 2 Download
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Corynebacterium diphtheriae, the agent of diphtheria, is a genetically diverse bacterial species. Although antimicrobial resistance has emerged against several drugs including first-line penicillin, the genomic determinants and population dynamics of resistance are largely unknown for this neglected human pathogen.
18p vibransone 28-03-2024 5 2 Download
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Residents of long-term care facilities (LTCF) may have high carriage rates of multidrug-resistant pathogens, but are not currently included in surveillance programmes for antimicrobial resistance or healthcareassociated infections. Here, we describe the value derived from a longitudinal epidemiological and genomic surveillance study of drug-resistant Escherichia coli in a LTCF in the United Kingdom (UK).
11p vioraclene 31-03-2024 2 2 Download
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Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most common healthcare-associated pathogens. To examine the role of inter-hospital patient sharing on MRSA transmission, a previous study collected 2,214 samples from 30 hospitals in Orange County, California and showed by spa typing that genetic differentiation decreased significantly with increased patient sharing.
10p vioraclene 31-03-2024 5 2 Download
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Klebsiella spp. are opportunistic pathogens which can cause severe infections, are often multi-drug resistant and are a common cause of hospital-acquired infections. Multiple new Klebsiella species have recently been described, yet their clinical impact and antibiotic resistance profiles are largely unknown.
16p vibransone 28-03-2024 1 1 Download
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Blood plasma proteins play an important role in immune defense against pathogens, including cytokine signaling, the complement system, and the acute-phase response. Recent large-scale studies have reported genetic (i.e., protein quantitative trait loci, pQTLs) and non-genetic factors, such as age and sex, as major determinants to inter-individual variability in immune response variation.
15p viellison 28-03-2024 3 2 Download