Pathological conditions

Obesity is well known that in various human pathological states such as: essential hypertension, coronary heart disease, type 2 diabetes mellitus,... Insulin resistance plays an important role in pathological state of diabetes. Recently, Katz et al provided QUICKI index (Quantitative insulin sensitivity check index) for insulin resistance condition evaluation.

4p vifaye 20-09-2024 4 1   Download

The study aimed to evaluate the cachexia status and its associated factors in lung cancer patients. Methods: The cross-sectional study was conducted on 97 lung cancer in patients at the Oncology Center, Military Hospital 103, between 2020 and 2021.

10p viyoko 20-09-2024 4 1   Download

Building a list of contraindicated drug interactions and evaluating the initial results of applying information technology to prevent contraindicated drug interactions in prescriptions at the Military Hospital 7.

5p viohoyo 02-04-2024 6 3   Download

Suburbs in Melbourne present to us a unique context with which a new approach towards urban form can be devised using the existing conditions and opportunities found with infrastructural developments. This thesis contains the investigations on the various 'pathologies' of the urban fabric specifically on the potential use of 'Spaces Left-Over After Planning' as by-product to infrastructural development in relation to the reinvigoration of Melbourne suburbs under the influence of current and future metropolitan growth pressures.

98p runthenight05 01-03-2023 10 4   Download

Neurodegenerative disorders, such as Huntington’s, Alzheimer’s, and Parkinson’s diseases, affect millions of people worldwide and currently there are few effective treatments and no cures for these diseases. Transgenic mice expressing human transgenes for huntingtin, amyloid precursor protein, and other genes associated with familial forms of neurodegenerative disease in humans provide remarkable tools for studying neurodegeneration because they mimic many of the pathological and behavioural features of the human conditions. ...

15p awards 06-04-2013 39 4   Download

Cone snails comprise
500 species of venomous molluscs, which have evolved the ability to generate multiple toxins with varied and often exquisite selectivity. One class, the a-conotoxins, is proving to be a powerful tool for the differentiation of nicotinic acetylcholine receptors (nAChRs). These comprise a large family of complex subtypes, whose significance in physiological functions and pathological conditions is increasingly becoming apparent.

15p dell39 03-04-2013 47 4   Download

Cells in various anatomical locations are constantly exposed to mechanical forces from shear, tensile and compressional forces. These forces are signifi-cantly exaggerated in a number of pathological conditions arising from various etiologies e.g., hypertension, obstruction and hemodynamic over-load.

11p inspiron33 25-03-2013 49 7   Download

Deciphering the laws that govern metabolic responses of complex systems is essential to understand physiological functioning, pathological conditions and the outcome of experimental manipulations of intact cells. To this aim, a theoretical and experimental sensitivity analysis, called modular meta-bolic control analysis (MMCA), was proposed.

14p inspiron33 23-03-2013 47 3   Download

Caspase-3 is a programmed cell death protease involved in neuronal apop-tosis during physiological development and under pathological conditions. It is a promising therapeutic target for treatment of neurodegenerative dis-eases. We reported previously that isoquinoline-1,3,4-trione and its deriva-tives inhibit caspase-3.

11p inspiron33 23-03-2013 49 4   Download

CCN4⁄Wnt-induced secreted protein 1 (WISP1) is one of the CCN (CTGF⁄Cyr61⁄Nov) family proteins. CCN members have typical structures composed of four conserved cysteine-rich modules and their variants lack-ing certain modules, generated by alternative splicing or gene mutations, have been described in various pathological conditions.

11p galaxyss3 21-03-2013 37 4   Download

Vascular endothelial growth factor (VEGF) family members play impor-tant roles in embryonic development and angiogenesis during wound healing and in pathological conditions such as tumor formation. Parapox-viruses express a new member of the VEGF family which is a functional mitogen that specifically activates VEGF receptor (VEGFR)-2 but not VEGFR-1.

11p media19 05-03-2013 26 3   Download

Nuclear factor-kappaB (NF-jB) has been proposed to serve a dual func-tion as a regulator of neuron survival in pathological conditions associated with neurodegeneration. NF-jB is a transcription family of factors com-prising five different proteins, namely p50, RelA⁄p65, c-Rel, RelB and p52, which can combine differently to form active dimers in response to external stimuli.

9p vinaphone15 27-02-2013 25 3   Download

Thrombin generation increases in several pathological conditions, including cancer, thromboembolism, diabetes and myeloproliferative syndromes. During tumor development, thrombin levels increase along with several other molecules, including cytokines and angiogenic factors. Under such conditions, it is reasonable to predict that thrombin may recognize new low-affinity substrates that usually are not recognized under low-expression levels conditions.

13p viettel02 22-02-2013 33 3   Download

Bile acid-binding proteins (BABPs) are cytosolic lipid chaperones that play central roles in driving bile flow, as well as in the adaptation to various pathological conditions, contributing to the maintenance of bile acid homeostasis and functional distribution within the cell.

13p viettel02 20-02-2013 31 3   Download

There is a tightly regulated interaction, which is well-conserved in evolution, between the metabolic and immune systems that is deranged in states of over- or under-nutrition. Obesity, an energy-rich condition, is characterized by the activation of an inflammatory process in metaboli-cally active sites such as adipose tissue, liver and immune cells.

8p viettel02 20-02-2013 28 3   Download

Proteins are occasionally converted from their normal soluble state to highly ordered fibrillar aggregates (amyloids), which give rise to pathologi-cal conditions that range from neurodegenerative disorders to systemic amyloidoses. Recent methodological advances in solid-state NMR and EPR spectroscopy have enabled determination of the 3D structure of sev-eral amyloids at residue-level resolution.

10p viettel02 20-02-2013 50 4   Download

Cathepsin B (EC 3.4.22.1) is one of the most versatile human cysteine cath-epsins. It is important for intracellular protein degradation under normal conditions and is involved in a number of pathological processes. The occluding loop makes cathepsin B unique among cysteine cathepsins.

8p viettel02 19-02-2013 30 4   Download

MicroRNAs (miRNAs) are a class of small noncoding RNAs that have gained status as important regulators of gene expression. Recent studies have demonstrated that miRNAs are aberrantly expressed in the cardiovas-cular system under some pathological conditions.

15p cosis54 05-01-2013 44 5   Download

Abstract Retinopathy of prematurity (ROP) is a vascular vitreoretinopathy that affects infants with short gestational age and low birth-weight. The condition is a multifactorial disease and is clinically similar to familial exudative vitreoretinopathy (FEVR), which is a bilateral hereditary eye disorder affecting full-term infants. Both of them are characterized by the abnormal vessel growth in the vitreous that can lead to vitreoretinal traction, retinal detachment and other complications resulting in blindness.

7p toshiba23 18-11-2011 45 2   Download

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition

11p toshiba17 31-10-2011 38 3   Download