Pathophysiological role

This review aims to elucidate the intricate role of IgE in pediatric asthma, thereby contributing to a deeper understanding of its pathophysiology and aiding in the development of more effective diagnostic and therapeutic strategies.

11p vikoch 27-06-2024 1 1   Download

Ebook "Cell polarity 2: Role in development and disease" provides a state-of-the art overview on the most relevant aspects of cell polarity. Volume 2 discusses the physiological and pathophysiological relevance of cell polarity. It especially focuses on pathophysiological conditions in which one or several aspects of cell polarity are impaired, and in which a loss of cell polarity possibly contributes to disease (e.g. epithelial-to-mesenchymal transition in cancer, role of polarity proteins in cancer).

228p ladongphongthanh1008 22-04-2024 2 1   Download

Alzheimer’s disease (AD) is characterized by robust microgliosis and phenotypic changes that accompany disease pathogenesis. Accumulating evidence from genetic studies suggests the importance of phospholipase C γ 2 (PLCG2) in late-onset AD (LOAD) pathophysiology. However, the role of PLCG2 in AD is still poorly understood.

13p viellison 28-03-2024 5 2   Download

Ebook "Ion channels (Topics in medicinal chemistry, Volume 3)" play a vital role in basic physiological functions such as generation of electrical activity in nerves and muscle, control of cardiac excitability, intracellular signaling, hormone secretion, cell proliferation and many other biological processes. Because of their prevalence and the critical role they play in virtually all tissue types and organs, ion channels are also involved in a number of pathophysiological conditions. The aim of this volume is to review recent advances in the field of ion channel related diseases.

177p manmanthanhla0201 27-02-2024 7 1   Download

Part 1 book "Handbook of venoms and toxins of reptiles" includes content: The field of reptile toxinology - snakes, lizards, and their venoms; recent advances in venomous snake systematics; reptile venom glands - form, function, and future; snake venom metalloproteinases; snake venom metalloproteinases - biological roles and participation in the pathophysiology of envenomation;... and other contents.

275p muasambanhan06 03-02-2024 4 1   Download

Ebook "Molecular and functional insights into the pulmonary vasculature" provides a comprehensive review of the structure, function and pathophysiology of the pulmonary vasculature. Emerging evidence reveals the multifaceted roles played by the pulmonary vasculature. To reflect those roles, the individual chapters address topics ranging from pulmonary blood vessel development to vascular endothelial apoptosis, and delve deeply into our current understanding of various aspects of the pulmonary vasculature.

90p lucchinguyen 28-12-2023 4 2   Download

Part 1 book "Veterinary allergy" includes content: Canine immunoglobulin E, the aberrant immune system in atopic dermatitis, allergens and environmental influence, the genetics of canine atopic dermatitis, skin barrier and its role in the pathophysiology of atopic dermatitis, the role of bacterial agents in the pathogenesis of canine atopic,... and other contents.

224p muasambanhan02 18-12-2023 0 0   Download

Part 1 book "Cardiac intensive care" includes content: Evolution of the coronary care unit, ethical issues in the cardiac intensive care unit, physical examination in the cardiac intensive care unit, role of the cardiovascular system in coupling the external environment to cellular respiration, regulation of cardiac output, coronary physiology and pathophysiology, pathophysiology of acute coronary syndromes, regulation of hemostasis and thrombosis,.... and other contents.

427p oursky09 12-11-2023 8 1   Download

Long non-coding RNAs (lncRNAs) play important roles in many pathophysiological processes, including cancer progression. Namely, lncRNA Receptor-tyrosine-kinase-like orphan receptor-1 antisense 1 (ROR1-AS1) is crucial for cancer occurrence and progression in organs such as the liver or bladder. However, its expression and role in cholangiocarcinoma (CCA) have not been thoroughly explored.

12p vioracle 29-09-2023 4 2   Download

Anti-nuclear matrix protein-2 (NXP2) antibody is associated with the severe, chronic myositis phenotype in juvenile dermatomyositis (JDM). Although hyperproduction of type I interferon is considered to play an important role in JDM, sequential changes in biomarkers associated with this pathophysiology have not yet been described in detail.

7p viwhitewolf 03-07-2023 3 2   Download

Caveolae are small, “omega-shaped” invaginations at the plasma membrane of the cell which are involved in a variety of processes including cholesterol transport, potocytosis and cell signalling. Within caveolae there are caveolae-associated proteins, and changes in expression of these molecules have been described to play a role in the pathophysiology of various diseases including cancer and cardiovascular disease.

10p vinarcissa 21-03-2023 6 1   Download

Cumulating evidence from rodent models points to a pathophysiological role of inflammatory signaling in the epileptic brain with Toll-like receptor-4 signaling acting as one key factor. However, there is an apparent lack of information about expression alterations affecting this pathway in canine patients with epilepsy.

14p vigalileogalilei 28-02-2022 13 1   Download

Platelets play a central role in the development of cardiovascular diseases and changes in their proteins are involved in the pathophysiology of heart diseases in humans. There is lack of knowledge about the possible role of platelets in congestive heart failure (CHF) in dogs.

13p vidarwin 23-02-2022 8 1   Download

Pancreatic ductal adenocarcinoma (PDAC), one of the most lethal malignancies, is increasing in incidence. However, the stromal reaction pathophysiology and its role in PDAC development remain unknown. We, therefore, investigated the potential role of histological chronic pancreatitis findings and chronic inflammation on surgical PDAC specimens and disease-specific survival (DSS).

12p vielonmusk 21-01-2022 13 0   Download

Recent studies reported that soluble epoxide hydrolase (sEH) plays an important role in lung diseases. However, the role of sEH in hyperoxia-induced ALI is unclear. Methods: ALI was induced by exposure to 100% oxygen in an airtight cage for 72 h in wild-type (WT) and sEH gene deletion (EPHX2−/− ) mice.

7p vampires36 30-12-2021 13 0   Download

Chronic osteoarthritic pain is not well understood in terms of its pathophysiological mechanism. Activated glial cells are thought to play a role in the maintenance of chronic pain. T98G glioblastoma cell line was previously observed to release higher amounts of interleukin-6 (IL-6) when treated with cerebrospinal fluid (CSF) from patients with another chronic pain condition, post-herpetic neuralgia.

7p vizhangzhidong 29-12-2021 8 0   Download

Angiogenesis, the formation of blood vessel from pre-existing ones, plays an important role in many pathophysiological diseases, such as cancer. Opioids are often used in clinic for the management of chronic pain in cancer patients at terminal phases. Here, we investigated and compared the efects and mechanisms of four opioids on angiogenesis.

10p vidietmarhopp 29-12-2021 17 0   Download

The etiology and pathophysiology of sarcoidosis remains unclear, with epidemiologic studies limited by its relatively low prevalence. The internet has prompted patients to seek information about medical diagnoses online; Google Trends provides access to an anonymized version of this data, which has a new role in epidemiology.

5p vimackenziebezos 29-11-2021 13 0   Download

Tuberculosis remains one of the leading causes of morbidity and mortality worldwide. Therefore, understanding the pathophysiology of Mycobacterium tuberculosis is imperative for developing new drugs. Posttranscriptional regulation plays a significant role in microbial adaptation to different growth conditions.

12p vijeeni2711 24-07-2021 12 0   Download

IL-4 and IL-13 play a critical yet poorly understood role in orchestrating the recruitment and activation of effector cells of the asthmatic response and driving the pathophysiology of allergic asthma.

11p vimontana2711 05-04-2021 10 2   Download