Patient subgroups
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Part 1 of ebook "Machine learning in medicine - A complete overview" provides readers with contents including: Chapter 1 - Hierarchical clustering and K-means clustering to identify subgroups in surveys; Chapter 2 - Density-based clustering to identify outlier groups in otherwise homogeneous data; Chapter 3 - Two step clustering to identify subgroups and predict subgroup memberships in individual future patients; Chapter 4 - Nearest neighbors for classifying new medicines; Chapter 5 - Predicting high-risk-bin memberships; Chapter 6 - Predicting outlier memberships;...
304p daonhiennhien 03-07-2024 1 1 Download
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PTEN is a multi-functional tumor suppressor protein regulating cell growth, immune signaling, neuronal function, and genome stability. Experimental characterization can help guide the clinical interpretation of the thousands of germline or somatic PTEN variants observed in patients.
17p vibransone 28-03-2024 1 1 Download
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Isolated pulmonary oligometastases as the first site of dissemination after initial resection of pancreatic ductal adenocarcinoma (PC) is a rare event, and the treatment in this subgroup is challenging. Recurrence in the lung after initial primary tumour resection is associated with the most long-term survivors of patients with metastatic PC.
7p vitiki 30-01-2024 4 2 Download
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Oropharyngeal squamous cell carcinoma (OPSCC) is the only subgroup of head neck cancer that presents with an increased incidence. Gender-specific studies in other cancer entities have revealed differences in treatment response and prognosis. However, only limited data in OPSCC according to gender and human papillomavirus (HPV) status exist.
12p vialfrednobel 23-12-2023 5 3 Download
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Conventional differential expression (DE) testing compares the grouped mean value of tumour samples to the grouped mean value of the normal samples, and may miss out dysregulated genes in small subgroup of patients. This is especially so for highly heterogeneous cancer like Hepatocellular Carcinoma (HCC).
16p vischultz 20-10-2023 5 1 Download
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To identify differences related to sex and define autism spectrum disorder (ASD) comorbidities female-enriched through a comprehensive multi-PheWAS intersection approach on big, real-world data. Although sex difference is a consistent and recognized feature of ASD, additional clinical correlates could help to identify potential disease subgroups, based on sex and age.
9p vighostrider 25-05-2023 4 2 Download
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There are over 363 customized risk models of the American College of Cardiology and the American Heart Association (ACC/AHA) pooled cohort equations (PCE) in the literature, but their gains in clinical utility are rarely evaluated. We build new risk models for patients with specific comorbidities and geographic locations and evaluate whether performance improvements translate to gains in clinical utility.
10p vighostrider 25-05-2023 3 2 Download
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Poor premorbid functional status (PFS) is associated with mortality after intensive care unit (ICU) admission in patients aged 80 years or older. In the subgroup of very old ICU patients, the ability to recover from critical illness varies irrespective of age. To assess the predictive ability of PFS also among the patients aged 85 or older we set out the current study.
9p vinobelprisen 26-03-2022 9 4 Download
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Intensive care unit (ICU) patients age 90 years or older represent a growing subgroup and place a huge financial burden on health care resources despite the benefit being unclear. This leads to ethical problems. The present investigation assessed the differences in outcome between nonagenarian and octogenarian ICU patients.
14p vinobelprisen 26-03-2022 23 4 Download
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Advanced gastric cancer (AGC) is a disease with poor prognosis due to the current lack of effective therapeutic strategies. Immune checkpoint blockade treatments have shown effect responses in patient subgroups but biomarkers remain challenging. Traditional classifcation of gastric cancer (GC) is based on genomic profiling and molecular features.
13p vielonmusk 21-01-2022 9 0 Download
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Intramural coronary arteries remain a rare coronary anatomic variant following ASO. The outcomes of ASO in this subgroup of patients is quite favorable. Long - term follow - up is necessary.
5p inception36 30-11-2021 8 1 Download
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Visceral metastases account for 48–67% of metastatic breast cancer (MBC) patients and presage a worse overall survival. Previous study suggested potential effect of nab-paclitaxel on patients with visceral metastases subgroups. This phase II trial was conducted to explore the efficacy and safety of nab-paclitaxel in such a high-risk group of patients.
8p vimahuateng 26-11-2021 10 1 Download
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To identify subgroups of female breast cancer patients with distinct self-reported employment interference (EI) profiles and determine which demographic, clinical, and symptom characteristics, and quality of life outcomes were associated with subgroup membership.
10p vimahuateng 26-11-2021 8 1 Download
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Movement control impairment reduces active control of movement. Patients with this might form an important subgroup among patients with mechanical cervical pain. Diagnosis is based on the observation of active movement tests.
8p viannito2711 20-04-2021 9 1 Download
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To identify distinct groups of patients with fibromyalgia (FM) with respect to multiple outcome measures. FM patients are heterogeneous and can be classified into distinct subgroups by simple descriptive rules derived from only 3 variables, which may guide individual patient management.
11p vianttinic2711 20-04-2021 7 1 Download
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Non-specific chronic low back pain (NSCLBP) is a major health problem. Identification of subgroups and appropriate treatment regimen was proposed as a key priority by the Cochrane Back Review Group. We developed a multimodal treatment (MMT) for patients with moderate to severe disability and medium risk of poor outcome.
11p vianttinic2711 20-04-2021 8 1 Download
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In some situations, practice guidelines do not provide firm evidence-based guidance regarding COPD treatment choices, especially when large trials have failed to identify subgroups of particularly good or poor responders to available medications.
10p vianthony2711 16-04-2021 8 1 Download
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Limited data exists regarding healthcare utilization, medical expenses, and prognosis of pulmonary hypertension (PH) according to the World Health Organization (WHO) classification. We aimed to investigate mortality risk, healthcare utilization and medical expenditure in patients with PH across the five diagnostic subgroups.
11p vimaine2711 26-03-2021 14 2 Download
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Epidemiological research on health effects of livestock exposure in population subgroups with compromised respiratory health is still limited. The present study explored the association between livestock exposure and comorbid/concurrent conditions in patients with overlapping diagnoses of asthma and COPD.
10p vimaine2711 26-03-2021 12 2 Download
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Revefenacin, a once-daily, long-acting muscarinic antagonist delivered via standard jet nebulizer, increased trough forced expiratory volume in 1 s (FEV1) in patients with moderate to very severe chronic obstructive pulmonary disease (COPD) in prior phase 3 trials. We evaluated the efficacy of revefenacin in patients with markers of more severe COPD.
10p vimaine2711 26-03-2021 10 2 Download