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Pediatric brain tumor
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Juvenile Pilocytic Astrocytomas (JPAs) are one of the most common pediatric brain tumors, and they are driven by aberrant activation of the mitogen-activated protein kinase (MAPK) signaling pathway. RAF-fusions are the most common genetic alterations identified in JPAs, with the prototypical KIAA1549-BRAF fusion leading to loss of BRAF’s auto-inhibitory domain and subsequent constitutive kinase activation.
13p
vileonardodavinci
23-12-2023
4
3
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Part 2 book "Patient derived tumor xenograft models - Promise, potential and practice" includes content: Pediatric and adult brain tumor PDX models, patient derived xenograft models of prostate tumors, patient derived xenograft model of pancreatic cancer, modeling breast cancer heterogeneity with patient derived xenografts, patient derived xenograft models of ovarian gynecologic tumors,... and other contents.
259p
oursky06
17-10-2023
1
1
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Neuroblastoma (NB) is a childhood malignant tumor,50% of high-risk NB children still have recurrence, and the long-term survival rate is very low. NB tumors expressing high levels of BDNF/TrkB are associated with poor survival outcomes.In this study, we show that the trends of serum concentration of BDNF at different growth stages after birth, and explore the relationship with NB replase.
9p
vioracle
29-09-2023
3
2
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Medulloblastoma (MB) is the most common malignant pediatric brain tumor that originates in the cerebellum and brainstem. Frequent somatic mutations and deregulated expression of epigenetic regulators in MB highlight the substantial role of epigenetic alterations.
25p
viarchimedes
26-01-2022
17
0
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Prognosis for pediatric metastatic Retinoblastoma (Rb) is poor and current therapies are limited by high systemic toxicity rates and insufficient therapeutic efficacy for metastatic Rb. Tumor dissemination to the brain is promoted by the heterogeneous adhesive and invasive properties of Rb cells within the tumor.
13p
vianrose2711
27-04-2021
13
1
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DNA methylation profiling of pediatric brain tumors offers a new way of diagnosing and subgrouping these tumors which improves current clinical diagnostics based on histopathology. We have therefore developed the MethPed classifier, which is a multiclass random forest algorithm, based on DNA methylation profiles from many subgroups of pediatric brain tumors.
3p
vioklahoma2711
19-11-2020
10
1
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High-grade (WHO grade III and IV) astrocytomas are aggressive malignant brain tumors affecting humans with a high risk of recurrence in both children and adults. To date, limited information is available on the genetic and molecular alterations important in the onset and progression of pediatric high-grade astrocytomas and, even less, on the prognostic factors that influence long-term outcome in children with recurrence.
8p
vijennie2711
29-09-2020
9
1
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Standard therapies for high grade glioma have failed to substantially improve survival and are associated with significant morbidity. At relapse, high grade gliomas, such as glioblastoma multiforme, are refractory to therapy and universally fatal.
5p
virose2711
24-09-2020
6
0
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Medulloblastoma is the most common type of pediatric brain tumor. Although numerous factors influence patient survival rates, more than 30% of all cases will ultimately be refractory to conventional therapies. Current standards of care are also associated with significant morbidities, giving impetus for the development of new treatments.
13p
virose2711
25-09-2020
7
1
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Pilocytic astrocytoma is the most common type of brain tumor in the pediatric population, with a generally favorable prognosis, although recurrences or leptomeningeal dissemination are sometimes also observed.
16p
vimoscow2711
29-08-2020
21
3
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Cancer survival comes at a price: pediatric cancer survivors bear a high risk for a wide range of cognitive difficulties. Therefore, interventions targeting these difficulties are required. The aim of the present clinical trial is to extend empirical evidence about efficacy of cognitive and physical training in pediatric cancer survivors.
10p
vibaku2711
22-07-2020
7
1
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Genetic alterations in pediatric primary brain tumors can be used as diagnostic and prognostic markers and are the basis for the development of new target therapies that, ideally, would be associated with lower mortality and morbidity.
10p
viputrajaya2711
22-06-2020
5
0
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Pediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known that the majority of PLGG have activation of the MAPK/ ERK pathway.
9p
vikuala271
13-06-2020
14
1
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The understanding of the molecular biology of pediatric neuronal and mixed neuronal-glial brain tumors is still insufficient due to low frequency and heterogeneity of those lesions which comprise several subtypes presenting neuronal and/or neuronal-glial differentiation.
11p
vikuala271
13-06-2020
7
1
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Human milk contains immune molecules involved in the protection of newborns against infections. We analyzed the concentration of Deleted in Malignant Brain Tumors 1 (DMBT1), a protein with functions in innate immunity, in breast milk.
9p
virubber2711
21-03-2020
8
0
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Advances in the treatment of childhood brain tumors have significantly improved survival rates. With improved survival rates, long-term treatment-related toxicities have become important, and the resulting complications can affect patients’ emotion and behavior.
10p
vivalanbo2711
19-03-2020
9
1
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About 2000 children and adolescents under the age of 18 are diagnosed with cancer each year in Germany. Because of current medical treatment methods, a high survival rate can be reached for many types of the disease. Nevertheless, patients face a number of long-term effects related to the treatment.
8p
vivalanbo2711
19-03-2020
9
0
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Socioeconomic disparities in cancer incidence and mortality in the United States persist and remain an urgent public health problem. Recent studies of cancer and both individual- and area- level socioeconomic status (SES) have found low SES or poverty to be associated with higher incidence of lung, cervical, stomach, oral, and esophageal cancer. 1-8 Also, a lower incidence of breast cancer and melanoma has been observed among persons residing in poorer areas.
51p
khongmuonnghe
07-01-2013
57
2
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The major pathogenic mechanism of poststreptococcal glomerulonephritis (PSGN) is an in situ immune complex formation due to deposition of streptococcal nephritogenic antigens, such as nephritis-associated plasmin receptor (NAPlr) and Streptococcal pyrogenic exotoxin B (SPE B). Both are capable of activating the alternate pathway of the complement cascade and enhance the expression of adhesion molecules. SPE B also stimulates the production of chemotactic cytokines. NAPlr was isolated from group A streptococcus and was shown to bind plasmin(ogen).
432p
kmkmkmkmkm
08-09-2012
56
3
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Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí hóa học đề tài : Development of the Japanese version of the Pediatric Quality of Life Inventory™ Brain Tumor Module
14p
dauphong10
31-01-2012
55
3
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